Expression of X-Linked Inhibitor of Apoptosis Protein (XIAP) in Breast Cancer Is Associated with Shorter Survival and Resistance to Chemotherapy

Devi, Gayathri R.; Finetti, Pascal; Morse, Michael A.; Lee, Seayoung; Nonneville, Alexandre de; Laere, Steven Van; Troy, Jesse D.; Geradts, Joseph; McCall, Shannon J.; Bertucci, François

doi:10.3390/cancers13112807

Cited by 19 publications

(11 citation statements)

References 67 publications

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“…239 Additionally, XIAP overexpression has also been reported in breast cancer, renal cancer, colon cancer and leukaemia and correlated with poor overall survival, thus, positioning it as a potential therapeutic for cancer treatment. [240][241][242][243][244] In a related study, overexpression of TRIM9 is opined to correlate with the upregulation of Bcl-2 and downregulation of caspases 9/7 leading to apoptosis inhibition in lung cancer. 245 Similarly, Yang et al 246 reported a correlation between TRIM9 overexpression and decreased caspase 3 activity in uterine leiomyoma.…”

Section: 32mentioning

confidence: 99%

The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

Sampson

Wang

Otkur

et al. 2023

Clinical & Translational Med

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Ubiquitination is one of the most important post‐translational modifications which plays a significant role in conserving the homeostasis of cellular proteins. In the ubiquitination process, ubiquitin is conjugated to target protein substrates for degradation, translocation or activation, dysregulation of which is linked to several diseases including various types of cancers. E3 ubiquitin ligases are regarded as the most influential ubiquitin enzyme owing to their ability to select, bind and recruit target substrates for ubiquitination. In particular, E3 ligases are pivotal in the cancer hallmarks pathways where they serve as tumour promoters or suppressors. The specificity of E3 ligases coupled with their implication in cancer hallmarks engendered the development of compounds that specifically target E3 ligases for cancer therapy. In this review, we highlight the role of E3 ligases in cancer hallmarks such as sustained proliferation via cell cycle progression, immune evasion and tumour promoting inflammation, and in the evasion of apoptosis. In addition, we summarise the application and the role of small compounds that target E3 ligases for cancer treatment along with the significance of targeting E3 ligases as potential cancer therapy.

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Section: 32mentioning

confidence: 99%

The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

Sampson

Wang

Otkur

et al. 2023

Clinical & Translational Med

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“…XIAP, strongly inhibited by CM treatment (−149.92 ± 93.7 fold), is an apoptosis inhibitor; it suppresses apoptosis by binding caspase and inhibiting caspase activation [50]. XIAP modulation is becoming an important target for cancer therapy, in fact, it may confer therapeutic resistance and may modulate signaling factors involved in other processes, such as necroptosis, autophagy and immunosuppression [51]. NOL3 is an apoptosis suppressor and is related to chemoresistance and radiotolerance in cancer cell [52].…”

Section: Mechanism Of Action Of Fraction C Of Ctoa and Cmmentioning

confidence: 99%

Jellyfish as an Alternative Source of Bioactive Antiproliferative Compounds

et al. 2022

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Jellyfish are commonly considered a nuisance for their negative effects on human activities (e.g., fisheries, power plants and tourism) and human health. However, jellyfish provide several benefits to humans and are commonly eaten in eastern countries. Additionally, recent studies have suggested that jellyfish may become a source of high-value molecules. In this study, we tested the effects of the methanolic extracts and enriched fractions, obtained by solid-phase extraction fractionation, from the scyphomedusae Pelagia noctiluca, Rhizostoma pulmo, Cotylorhiza tuberculata and the cubomedusa Caryddea marsupialis on different human cancer cell lines in order to evaluate a potential antiproliferative activity. Our results indicated that fraction C from Caryddea marsupialis-(CM) and C. tuberculata oral arms (CTOA) were the most active to reduce cell viability in a dose-dependent manner. LC/MS based dereplication analyses highlighted that both bioactive fractions contained mainly fatty acids and derivatives, with CM additionally containing small peptides (0.7–0.8 kDa), which might contribute to its higher biological activity. The mechanism of action behind the most active fraction was investigated using PCR arrays. Results showed that the fraction C of CM can reduce the expression of genes involved in apoptosis inhibition in melanoma-treated cells, which makes jellyfish a potential new source of antiproliferative drugs to be exploited in the future.

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“…Copper-containing ferroxidase -ceruloplasmin, a large amount of which is concentrated in Sertoli cells, participates in transport of iron ions, which are the basis for such fundamental cellular processes as oxidative phosphorylation and oxygen transport (Vashchenko & MacGillivray, 2013;Tvrda et al, 2015). Other than enzyme cofactor, copper takes part in realization of signal pathways of apoptosis development by inhibiting activation of caspases 3, 7 and 9 (Mufti et al, 2006;Devi et al, 2021). This confirms the leading role of copper in seminal plasma in the control of the number of live spermatozoids.…”

Section: •-mentioning

confidence: 99%

Effects of copper citrate on physiological-biochemical parameters of ejaculate of sire boars

Shostya

Siabro

2022

Regul. Mech. Biosyst.

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Revealing peculiarities of the course of physiological and biochemical processes in the formation of parameters of ejaculate allows effective correlation of biological completeness of spermatozoids based on the use of chelate compounds of limiting microelements, particularly copper. The study was focused on determining changes in processes of spermatogenesis during correction of mineral nutrition. In the experiment, we used adult boars of the same age, live weight and quality of ejaculates. They consumed copper citrate during the 45 day experiment in doses higher than the norm by 10% (1.5 mg per 1 kg of combined feed) and 20% (3 mg per 1 kg of combined feed) compared with the control. We determined difference in the effects of different doses of copper citrate on the formation of parameters of ejaculates in sire boars. Addition of the mineral additive to the feed in the doses 10% exceeding the norm promoted increase in the parameters of functional activity of spermatozoids – mobility and survival – on day 45 of the intake, which occurred against the background of acceleration of peroxidation processes (increase in the concentration of thiobarbituric acid of active compounds) and activation of the system of antioxidant protection – increase in the activity of superoxide dismutase and decrease in the level of catalase in the sperm. At the same time, we observed increase in the morphometric parameters of spermatozoids – general length, width, length and volume of the head. On day 30, sire boars that had been consuming copper citrate in the amounts 20% above the norm were observed to have increase in concentration of spermatozoids, their mobility and survivability, though a decrease was seen in the morphometric parameters of the gametes. Further intake of this element caused increase in the amount of abnormal forms of spermatozoids. Under the action of this additive, we determined increase in the amount of metabolites of lipid peroxidation – conjugated dienes and thiobarbituric acids of active compounds, and also weakening of the system of antioxidative protection – decrease in the content of reduced glutathione and accumulation of dehydroascorbic acid. Thus, the intake of copper citrate in the amounts of 10% above the norm facilitated morpho-functional parameters of spermatozoids by activating the system of antioxidant protection. It would be promising to conduct further research to determine the effects of copper citrate on the processes of activation and capacitation of spermatozoids and fertilization of oocytes in in vivo and in vitro conditions.

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Expression of X-Linked Inhibitor of Apoptosis Protein (XIAP) in Breast Cancer Is Associated with Shorter Survival and Resistance to Chemotherapy

Cited by 19 publications

References 67 publications

The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

Jellyfish as an Alternative Source of Bioactive Antiproliferative Compounds

Effects of copper citrate on physiological-biochemical parameters of ejaculate of sire boars

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