Expression of Viral Arthritis-Tenosynovitis Infection in Immunosuppressed Chickens

Naqi, S. A.; Pugh, Roberta; N, Sahin

doi:10.3382/ps.0630825

Cited by 3 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results, however, differ from those reported by Naqi et al (1984) who produced only a subclinical infection by subcutaneous inoculation of reovirus in Cy and IBDV immunosuppressed chickens. Possibly, one of the main reasons for the conflicting results may be the lower Cy dose of only 3.0 mg in total used by Naqi et al (1984) for it is known that at low doses Cy immunosuppression is variable (Hiraga et al, 1976;Glick, 1977).…”

Section: Virus Isolationcontrasting

confidence: 56%

“…Possibly, one of the main reasons for the conflicting results may be the lower Cy dose of only 3.0 mg in total used by Naqi et al (1984) for it is known that at low doses Cy immunosuppression is variable (Hiraga et al, 1976;Glick, 1977). Another explanation might relate to the virulence of the reovirus involved, but dose of virus is not implicated because in the present study one of the doses was the same as that used by Naqi et al (1984).…”

Section: Virus Isolationmentioning

confidence: 49%

See 1 more Smart Citation

Effects of experimental immunosuppression on reovirus‐induced tenosynovitis in light‐hybrid chickens

1987

View full text Add to dashboard Cite

SUMMARYGroups of specific pathogen-free light-hybrid chickens which had been immunosuppressed either by surgical thymectomy (Tx) or surgical bursectomy (Bx) or cyclophosphamide (Cy) treatment or Tx plus Cy treatment (Tx + Cy), as well as intact (untreated) birds, were inoculated with graded doses of an arthrotropic avian reovirus at 1 day of age and observed up to 5 weeks post-inoculation (p.i.). Cy-treatment with or without Tx considerably increased the mortality, incidence of gross leg lesions and severity of microscopic lesions due to reovirus infection. The Bx group showed only a significant increase in mortality, and the Tx group response was generally similar to the untreated group. Dead birds showed hepatic necrosis, which in Cy-treated groups (Cy, Tx + Cy) was associated with calcification. Surviving Cy-treated birds had acute tenosynovitis characterised grossly by large amounts of serous exudate in leg tendon sheaths, and microscopically by a massive heterophilic but only mild lymphocytic infiltration of tendon sheaths. Tenosynovitis lesions in Bx birds were generally similar to those of the untreated chickens, i.e. grossly small amounts of yellowish brown gelatinous exudate and microscopically moderate chronic inflammatory changes in leg tendon sheaths. In Tx birds gross lesions were rarely seen and the microscopic lesions were often very mild.Reovirus could be recovered from cloacal swabs from untreated and Tx birds for 2 weeks, Bx birds for 3 to 4 weeks, and Cy and Tx + Cy chickens continuously throughout. Reovirus was isolated from tendon tissue of all Cy and Tx + Cy infected birds examined at 5 weeks p.i. and gross tenosynovitis lesions were seen in all birds. The virus was recovered from the tendons of only a proportion of the infected untreated, Tx and Bx groups, and overall more frequently from apparently normal birds. This was especially marked in the infected Tx group. Antibody responses as shown by gel precipitation and virus neutralisation were

show abstract