Expression of vascular endothelial growth factor (VEGF) and factor VIII in the gilt placenta and its relation to fetal development

Guimarães, Gregório Corrêa; Alves, Lorena A.; Betarelli, R. P.; Guimarães, Camila S.O.; Helmo, Fernanda Rodrígues; Júnior, Carlos Donizete Pereira; Corrêa, Rosana Rosa Miranda; Zangerônimo, Márcio Gilberto

doi:10.1016/j.theriogenology.2017.01.002

Cited by 14 publications

(16 citation statements)

References 21 publications

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“…It has been suggested Zeb1 can induce angiogenesis and promote the expression of VEGF, thereby promoting angiogenesis (27). VEGF is involved in the occurrence of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

The role of Zeb1 in the pathogenesis of morbidly adherent placenta

Yang

et al. 2019

Mol Med Report

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Zinc finger E-box-binding homeobox 1 (Zeb1) is a promoter of epithelial-mesenchymal transformation, which may serve an important role in morbidly adherent placenta (MAP). In the present study, the protein expression levels of Zeb1 were examined in the placenta tissues of 60 patients, including 20 patients with placenta accreta (PA) and 20 patients with placenta previa without PA (UPA) and 20 patients in late pregnancy that delivered by cesarean section (normal). The expression levels of Zeb1, N-cadherin, vascular endothelial growth factor (VEGF), Tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2), and tumor necrosis factor-related apoptosis-inducing ligand-receptor 3 (TRAIL-R3) were higher in PA tissues compared with in normal control tissues. The expression levels of E-cadherin and TRAIL-R2 were decreased in PA tissues compared with in normal control tissues. These findings indicated that Zeb1 may serve an important role in placental attachment, thus promoting the development of dangerous PA. Overexpression of Zeb1 may upregulate the expression levels of N-cadherin, VEGF, TRAIL-R3, cyclin D1 and Bcl-2, and downregulate the expression levels of E-cadherin and TRAIL-R2. In addition, Zeb1 regulated the viability, apoptosis and migration of HTR-8/SV neo cells and human umbilical vein endothelial cells by regulating the Akt pathway. In conclusion, these findings indicated that Zeb1 may promote placental implantation by activating the Akt signaling pathway, thus providing a theoretical basis for investigating the causes of MAP.

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“…It has been suggested Zeb1 can induce angiogenesis and promote the expression of VEGF, thereby promoting angiogenesis (27). VEGF is involved in the occurrence of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

The role of Zeb1 in the pathogenesis of morbidly adherent placenta

Yang

et al. 2019

Mol Med Report

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“…The expression of VEGF also has been studied in placental tissue, as this substance is related to the development of blood vessels responsible for fetal nutrition during pregnancy. [27] Even though placental tissue is highly vascularized, the relative expression of VEGF ranged only from 11% to 17% in uteroplacental tissue obtained from gilts at different gestational ages. This finding may help explain the low absolute levels of VEGF expression observed in our study, although altered degradation cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

Reversible Pulmonary Trunk Banding. XI: Myocardial Vascular Endothelial Growth Factor Expression in Young Goats Submitted to Ventricular Retraining

Assad

Rocha²,

Aiello

et al. 2019

Preprint

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BackgroundVentricle retraining has been extensively studied by our laboratory. Previous studies have demonstrated that intermittent overload causes a more efficient ventricular hypertrophy. The adaptive mechanisms involved in the ventricle retraining are not completely established. This study assessed vascular endothelial growth factor (VEGF) expression in the ventricles of goats submitted to systolic overload.MethodsTwenty-one young goats were divided into 3 groups (7 animals each): control, 96-hour continuous systolic overload, and intermittent systolic overload (four 12-hour periods of systolic overload paired with 12-hour resting period). During the 96-hour protocol, systolic overload was adjusted to achieve a right ventricular (RV) / aortic pressure ratio of 0.7. Hemodynamic evaluations were performed daily before and after systolic overload. Echocardiograms were obtained preoperatively and at protocol end to measure cardiac masses thickness. At study end, the animals were killed for morphologic evaluation and immunohistochemical assessment of VEGF expression.ResultsRV-trained groups developed hypertrophy of RV and septal masses, confirmed by increased weight and thickness, as expected. In the study groups, there was a small but significantly increased water content of the RV and septum compared with those in the control group (p<0.002). VEGF expression in the RV myocardium was greater in the intermittent group (2.89% ± 0.41%) than in the continuous (1.80% ± 0.19%) and control (1.43% ± 0.18%) groups (p<0.023).ConclusionsIntermittent systolic overload promotes greater upregulation of VEGF expression in the subpulmonary ventricle, an adaptation that provides a mechanism for increased myocardial perfusion during the rapid myocardial hypertrophy of young goats.

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“…In the embryo, the expression of VEGF and its receptors ( VEGFR-1 and VEGFR-2 ) are also conserved in different species. For example, VEGF expression has been related to fetal weight increase in porcine embryos [ 55 ], in which VEGF expression was detected in TE cells at Day 14 of pregnancy [ 50 ]. VEGF , VEGFR-1 , and VEGFR-2 mRNA have been found in vitellin sacs and TEs of bovine embryos [ 49 , 56 , 57 ].…”

Section: Growth Factors and Early Developmentmentioning

confidence: 99%

Pluripotency and Growth Factors in Early Embryonic Development of Mammals: A Comparative Approach

Llobat

2021

Veterinary Sciences

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The regulation of early events in mammalian embryonic development is a complex process. In the early stages, pluripotency, cellular differentiation, and growth should occur at specific times and these events are regulated by different genes that are expressed at specific times and locations. The genes related to pluripotency and cellular differentiation, and growth factors that determine successful embryonic development are different (or differentially expressed) among mammalian species. Some genes are fundamental for controlling pluripotency in some species but less fundamental in others, for example, Oct4 is particularly relevant in bovine early embryonic development, whereas Oct4 inhibition does not affect ovine early embryonic development. In addition, some mechanisms that regulate cellular differentiation do not seem to be clear or evolutionarily conserved. After cellular differentiation, growth factors are relevant in early development, and their effects also differ among species, for example, insulin-like growth factor improves the blastocyst development rate in some species but does not have the same effect in mice. Some growth factors influence genes related to pluripotency, and therefore, their role in early embryo development is not limited to cell growth but could also involve the earliest stages of development. In this review, we summarize the differences among mammalian species regarding the regulation of pluripotency, cellular differentiation, and growth factors in the early stages of embryonic development.

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Expression of vascular endothelial growth factor (VEGF) and factor VIII in the gilt placenta and its relation to fetal development

Cited by 14 publications

References 21 publications

The role of Zeb1 in the pathogenesis of morbidly adherent placenta

The role of Zeb1 in the pathogenesis of morbidly adherent placenta

Reversible Pulmonary Trunk Banding. XI: Myocardial Vascular Endothelial Growth Factor Expression in Young Goats Submitted to Ventricular Retraining

Pluripotency and Growth Factors in Early Embryonic Development of Mammals: A Comparative Approach

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