The role of Zeb1 in the pathogenesis of morbidly adherent placenta

Li, Na; Yang, Tian; Yu, Wenqian; Líu, Hao; Qiao, Chong; Liu, Caixia

doi:10.3892/mmr.2019.10490

Cited by 8 publications

(15 citation statements)

References 31 publications

(34 reference statements)

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“…The simultaneous up-regulation of p21 and Cyclin D1 has been shown also in senescent cells ( 82 , 83 ). Consistent with our study Li et al ( 26 ) reported that Cyclin D1 was up-regulated in Placenta accreta . The result that pRb was significantly decreased in late AIP placentas compared to late gestational age-matched controls could contribute to cellular senescence in late AIP.…”

Section: Discussionsupporting

confidence: 93%

“…Ray J et al ( 25 ) found that in vitro differentiation from CTB to STB coincided with a decrease in cyclin E1, which is a G1/S phase cell cycle regulator that can inhibit cell cycle progression ( 25 ). Previous studies also reported that the AKT signaling pathway is involved in the invasion process as well as cell migration which have a relationship with the placenta diseases PE and AIP ( 19 , 26 , 27 ).…”

Section: Introductionmentioning

confidence: 89%

“…As the cesarean section rate increases, the incidence of AIP has increased over the past 50 years (14). It is difficult for patients with AIP to strip the entire placenta after delivery, which leads to serious obstetric complications, such as hemorrhages, hysterectomy, and even maternal mortality (15,16). The molecular mechanisms of invasive placentation in AIP are poorly understood; it might be a combination of primary absence of the decidua or basal plate, abnormal maternal vascular remodelling, and excessive EVT invasion (17) In summary, PE and AIP are consequences of two opposing trophoblast invasion disorders.…”

Section: Introductionmentioning

confidence: 99%

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CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta

Duan

Schimmelmann

et al. 2020

Front. Endocrinol.

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Objectives An adequate development of the placenta includes trophoblast differentiation with the processes of trophoblast migration, invasion, cellular senescence and apoptosis which are all crucial to establishing a successful pregnancy. Altered placental development and function lead to placental diseases such as preeclampsia (PE) which is mainly characterized by insufficient trophoblast invasion and abnormally invasive placenta (AIP) disorders ( Placenta accreta , increta , or percreta) which are characterized by excessive trophoblast invasion. Both of them will cause maternal and fetal morbidity/mortality. However, the etiology of these diseases is still unclear. Our previous study has shown that the matricellular protein nephroblastoma overexpressed (NOV, CCN3) induces G0/G1 cell cycle arrest, drives trophoblast cells into senescence and activates FAK and Akt kinases resulting in reduced cell proliferation and enhanced migration capability of the human trophoblast cell line SGHPL-5. The present study focuses on whether CCN3 can alter cell cycle-regulated pathways associated with trophoblast senescence and invasion activity in pathological versus gestational age-matched control placentas. Methods Cell cycle regulator proteins were investigated by immunoblotting and qPCR. For localization of CCN3, p16, p21, and Cyclin D1 proteins, co-immunohistochemistry was performed. Results In early-onset PE placentas, CCN3 was expressed at a significantly lower level compared to gestational age-matched controls. The decrease of CCN3 level is associated with an increase in p53, Cyclin E1 and pRb protein expression, whereas the level of cleaved Notch-1, p21, Cyclin D1, pFAK, pAKT, and pmTOR protein decreased. In term AIP placentas, the expression of CCN3 was significantly increased compared to matched term controls. This increase was correlated to an increase in p53, p16, p21, Cyclin D1, cleaved Notch-1, pFAK, pAkt, and pmTOR whereas pRb was significantly decreased. However, in late PE and early AIP placentas, no significant differences in CCN3, p16, p21, Cyclin D1, p53, and cleaved Notch-1 expression were found when matched to appropriate controls. Conclusions CCN3 expression levels are correlated to markers of cell cycle arrest oppositely in PE and AIP by activating the FAK/AKT pathway in AIP or down-regulating in PE. This may be one mechanism to explain the different pathological features of placental diseases, PE and AIP.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta

Duan

Schimmelmann

et al. 2020

Front. Endocrinol.

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“…Previous studies demonstrated that the 5′-flanking region of the N-cadherin gene contains several putative transcriptional regulatory elements, such as E-box and Sp1 [ 26 ]. Slug, ZEB1 and Twist1 transcriptional factors are known to bind to E-box elements and promote N-cadherin expression [ [27] , [28] , [29] ]. However, mRNA levels of these transcriptional factors were not decreased in Cre; PKN2 flox/flox cells compared to PKN2 flox/flox cells ( Supplementary Fig.…”

Section: Discussionmentioning

confidence: 99%

PKN2 is involved in aggregation and spheroid formation of fibroblasts in suspension culture by regulating cell motility and N-cadherin expression

Kubouchi

Mukai

2021

Biochemistry and Biophysics Reports

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“…Pregnant women with placenta previa are prone to vaginal bleeding. Clinically, placenta previa is divided into pernicious placenta previa (PPP) and non-dangerous placenta previa [2] . PPP refers to the placenta attached to the scar of the previous cesarean section, or the placenta previa with placenta accreta or placental adhesions.…”

mentioning

confidence: 99%

Treatment of Pernicious Placenta Previa with Ergonoxine and Spiral Suture of Lower Uterine Segment

Li¹,

Wang²,

An³

et al. 2021

ijps

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Li et al.: Treatment of PPP with Ergonovine and lower uterine spiral sutureThe aim of this study was to investigate the effect of ergonovine combined with spiral suture of lower uterine segment in the treatment of pernicious placenta previa hemorrhage after cesarean section. A retrospective analysis of the clinical data of 74 patients hospitalized in our hospital due to pernicious placenta previa from January to February 2016, divided them into a study group and a control group. The study group included 37 patients who received ergonovine injection into the lower uterine muscle wall+spiral suture of the lower uterus during cesarean section, and the control group included 37 cases who received the conventional method and row suture of the lower uterus. The blood loss during operation, 2 h after operation and 2-24 h after operation, operation time, hysterectomy rate, postoperative uterine involution and incision healing were observed. The systolic and diastolic blood pressure, pulse level and the incidence of postoperative complications were compared between the two groups. The results showed that the combined application of ergonovine and lower uterine spiral suture was effective in treating pernicious placenta previa hemorrhage after cesarean section. It was a simple, easy, safe and reliable surgical hemostasis method, which could effectively control massive bleeding during the operation, avoid the removal of the uterus, and completely remove the placenta and restored the shape of the lower part of the uterus by ring-shaped narrowing, which helped the uterus to regenerate after delivery.

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The role of Zeb1 in the pathogenesis of morbidly adherent placenta

Cited by 8 publications

References 31 publications

CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta

CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta

PKN2 is involved in aggregation and spheroid formation of fibroblasts in suspension culture by regulating cell motility and N-cadherin expression

Treatment of Pernicious Placenta Previa with Ergonoxine and Spiral Suture of Lower Uterine Segment

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