Expression of vascular endothelial growth factor in melanocytic nevi

Gajanin, Vesna; Krivokuća, Zdenka; Gajanin, Radoslav; Vujković, Zoran; Sladojević, Igor; Zrnić, Bogdan

doi:10.2298/mpns1102029g

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…[10][11][12] Previously, some reports revealed that melanocytic nevus had no or low expression of VEGF. 13,14 As for FGF-2, Giehl et al 15 reported that 55% cases of melanocytic nevus expressed FGF-2, and the staining intensities were moderate except for one case with strong staining. However, in our case of ASN, these angiogenic factors were strongly expressed in the melanocytes as well as in the endothelial cells, and the staining intensities in the immunohistochemical studies were higher than in our previously experienced cases of melanocytic nevus.…”

Section: Discussionmentioning

confidence: 99%

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Angiomatoid Spitz nevus with surrounding pagetoid melanocytic proliferation on the sole of the foot: An unusual case report with immunohistochemical studies for angiogenic factors

Anju

Nakamura

Okiyama

et al. 2020

The Journal of Dermatology

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Angiomatoid Spitz nevus (ASN) is a rare histological variant of Spitz nevus (SN) that is characterized by prominent blood vessel proliferation around the intradermal melanocytes of SN. In contrast, SN may have pagetoid components, which are characterized by epidermal proliferation of single melanocytes. However, cases of ASN with predominant pagetoid melanocytic proliferation in the epidermis have not been reported. Here, we report a case of ASN with surrounding pagetoid melanocytic proliferation without formation of tumor nests in the epidermis in the plantar region. A 12-year-old girl presented with a bright red nodule surrounded by a brown macule on the sole of her right foot. Histologically, the nodule showed tumor nests in the dermis, composed of spindle or epithelioid melanocytes containing abundant cytoplasm and large nuclei. Around the nests, numerous blood vessels were seen. In the overlying epidermis of the nodule, numerous eosinophilic Kamino bodies were found along the dermal-epidermal interface. In the macule, proliferation of oval melanocytes was present as single-cell units in the epidermis. Theses melanocytes had abundant cytoplasm with large nuclei, which were larger than those of the surrounding keratinocytes. From these findings, a diagnosis of ASN with surrounding pagetoid melanocytic proliferation was made. Vascular endothelial growth factor and fibroblast growth factor 2 were strongly expressed in the melanocytes as well as in the endothelial cells in our case. Therefore, angiogenic factors produced by the melanocytes of SN might have played important roles in the surrounding angiogenesis of this case.

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Section: Discussionmentioning

confidence: 99%

“…In PG, VEGF and FGF‐2 have been shown to play vital roles in its angiogenesis, which could be produced mainly by endothelial cells and inflammatory cells . Previously, some reports revealed that melanocytic nevus had no or low expression of VEGF . As for FGF‐2, Giehl et al.…”

Section: Discussionmentioning

confidence: 99%