Expression of Vascular Endothelial Growth Factor in Human Ocular Adnexal Lymphoma

Kinoshita, Satoshi; Kase, Satoru; Andõ, Ryõ; Dong, Zhenyu; Fukuhara, Junichi; Dong, Yoko; Inafuku, Saori; Noda, Kousuke; Noda, Mika; Kanda, Atsuhiro; Ishida, Susumu

doi:10.1167/iovs.13-13510

Cited by 10 publications

(4 citation statements)

References 23 publications

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“…Intratumoral microvessel density was calculated according to the previous reports. 8 , 9 Briefly, the number of CD34-immunopositive microvessels in the tumor tissues was directly counted under light microscope (objective ×40). The counting was done in two or three high-power fields, and the numbers were then averaged to determine the microvessel density.…”

Section: Methodsmentioning

confidence: 99%

Expression of VEGF in human conjunctival melanoma analyzed with immunohistochemistry

Kase

Kikuchi

Ishida

2018

OPTH

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PurposeThe aim of this study was to examine the immunolocalization of VEGF-A and CD34, a marker of endothelial cells, in human conjunctival melanoma.MethodsThis study retrospectively analyzed primary conjunctival melanoma patients who underwent surgical resection of the tumor. All excised tissues were fixed with paraformaldehyde and embedded in paraffin, which were then submitted for immunohistochemistry with anti-VEGF and CD34 antibodies.ResultsThe study sample comprised 4 female and two male melanoma patients. The age of the patients ranged from 64 to 84 (average age, 73) years. Histopathology of the surgically resected tumor tissues demonstrated accumulation of polygonal atypical malignant cells producing melanin. Cytoplasmic immunoreactivity for VEGF was clearly observed in tumor cells of all six tumors. In contrast, CD34-positive endothelial cells were less marked in the melanoma tissues than in the adjacent noncancerous subconjunctival stroma.ConclusionVEGF immunoreactivity was observed in conjunctival melanoma tissues, in which endothelial cells were hardly observed. These results suggest that although VEGF is expressed, conjunctival melanoma is a hypovascular tumor.

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Section: Methodsmentioning

confidence: 99%

Expression of VEGF in human conjunctival melanoma analyzed with immunohistochemistry

Kase

Kikuchi

Ishida

2018

OPTH

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“…VEGF expression may be strongly correlated with pathological characteristics of diffuse large B cell lymphoma (DLBCL) [41]. VEGF plays a significant role in the pathogenesis and tumor angiogenesis of ocular adnexal lymphoma [42]. Both VEGFR-2 and VEGFR-3 can serve as markers for prognosis of papillary renal cell carcinoma.…”

Section: Non-digestive Cancersmentioning

confidence: 99%

VEGF expression in pancreatic cancer and other malignancies: a review of the literature

Costache

Ioana

Iordache

et al. 2015

Romanian Journal of Internal Medicine

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Angiogenesis is a crucial event for tumor growth and it is regulated predominantly by several different growth factors. Vascular endothelial growth factor protein family (VEGF) and its receptors are probably the most important tissue factors responsible for angioblast differentiation and tube formation. VEGF protein family currently comprises several members: VEGF (or VEGF-A), VEGF-B, VEGF-C and VEGF-D, VEGF-F, placental growth factor (PlGF), and their receptors VEGFR-1, VEGFR-2 and VEGFR-3. VEGF is a key angiogenic growth factor and its level of expression is a critical marker for detection of the angiogenic diseases. The potent role of VEGF in tumor angiogenesis has been widely described in the past decade, being expressed in most types of nondigestive and digestive cancers. VEGF family members play an important role in the development of pancreatic cancer (especially VEGF-A, VEGF-C, VEGF-D, VEGFR-1 and VEGFR-2). VEGF-A is the most specific and prominent angiogenic factor among all family members and VEGFR-2 is the most important receptor in evaluating the angiogenesis in pancreatic cancer. Thus, VEGF overexpression may be considered as a diagnostic marker and as a poor prognostic factor of the disease.

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“…IgG4-ROD simulates B-cell malignant lymphomas such as extra nodal marginal zone B-cell lymphoma (EMZL) (2,3), and the differentiation is sometimes difficult based on histopathological examination only. In addition, we have shown that CD20 and vascular endothelial growth factorimmunopositive B lymphoid cells were detected in tumor tissues of both ocular adnexal EMZL and benign reactive lymphoid hyperplasia (4). Therefore, further information should be collected to differentiate benign lymphoproliferative disorders from EMZL for ophthalmologists.…”

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confidence: 99%

Usefulness of Flow Cytometry in Diagnosis of IgG4-Related Ophthalmic Disease and Extranodal Marginal Zone B-Cell Lymphoma of the Ocular Adnexa

Kase

Ishijima

Uraki

et al. 2017

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Expression of Vascular Endothelial Growth Factor in Human Ocular Adnexal Lymphoma

Abstract: This study demonstrated increased VEGF expression in human conjunctival and orbital EMZL compared with that in RLH, suggesting that VEGF plays a significant role in the pathogenesis and tumor angiogenesis of ocular adnexal lymphoma.

Cited by 10 publications

References 23 publications

Expression of VEGF in human conjunctival melanoma analyzed with immunohistochemistry

Expression of VEGF in human conjunctival melanoma analyzed with immunohistochemistry

VEGF expression in pancreatic cancer and other malignancies: a review of the literature

Usefulness of Flow Cytometry in Diagnosis of IgG4-Related Ophthalmic Disease and Extranodal Marginal Zone B-Cell Lymphoma of the Ocular Adnexa

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