Expression of VAChT and 5-HT in Ulcerative colitis dendritic cells

Pergolizzi, Simona; Rizzo, Giuseppina; Favaloro, Angelo; Alesci, Alessio; Pallio, Socrate; Melita, G; Cutroneo, Giuseppina; Lauriano, Eugenia Rita

doi:10.1016/j.acthis.2021.151715

Cited by 32 publications

(25 citation statements)

References 44 publications

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“…Kidney and gill samples were fixed in 4% paraformaldehyde in 0.1 M phosphate-buffered saline (pH 7.4) for 12–18 h, then dehydrated in graded ethanol, cleared in xylene, and embedded in Paraplast ® (McCormick Scientific LLC, St. Louis, MO, USA). Finally, serial slices (3–5 m thick) were created using a rotary microtome (LEICA 2065 Supercut, Poway, CA, USA) [ 49 , 50 , 51 , 52 ].…”

Section: Methodsmentioning

confidence: 99%

Histological and Chemical Analysis of Heavy Metals in Kidney and Gills of Boops boops: Melanomacrophages Centers and Rodlet Cells as Environmental Biomarkers

Alesci

Cicero

Fumia

et al. 2022

Toxics

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Industrialization has resulted in a massive increase in garbage output, which is frequently discharged or stored in waterways like rivers and seas. Due to their toxicity, durability, bioaccumulation, and biomagnification, heavy metals (such as mercury, cadmium, and lead) have been identified as strong biological poisons. Their presence in the aquatic environment has the potential to affect water quality parameters and aquatic life in general. Teleosts’ histopathology provides a sensitive indicator of pollutant-induced stress, because their organs have a central role in the transformation of different active chemical compounds in the aquatic environment. In particular, the gills, kidneys, and liver are placed at the center of toxicological studies. The purpose of this study is to examine the morphological changes caused by heavy metals in the kidney and gills of Boops boops, with a focus on melanomacrophages centers (MMCs) and rodlet cells (RCs) as environmental biomarkers, using histological and histochemical stainings (hematoxylin/eosin, Van Gieson trichrome, Periodic Acid Schiff reaction, and Alcian Blue/PAS 2.5), and immunoperoxidase methods. Our findings show an increase of MMCs and RCs linked to higher exposure to heavy metals, confirming the role of these aggregates and cells as reliable biomarkers of potential aquatic environmental changes reflected in fish fauna. The cytological study of RCs and MMCs could be important in gaining a better understanding of the complicated immune systems of teleosts.

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Section: Methodsmentioning

confidence: 99%

Histological and Chemical Analysis of Heavy Metals in Kidney and Gills of Boops boops: Melanomacrophages Centers and Rodlet Cells as Environmental Biomarkers

Alesci

Cicero

Fumia

et al. 2022

Toxics

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“…DCs are a heterogeneous family of antigen-presenting immune cells (APC) [66]. These cells are primary sentinels and share many characteristics with macrophages, which may also present antigen on major histocompatibility complex (MHC) class II molecules, although not as effectively as DCs.…”

Section: Dendritic Cellsmentioning

confidence: 99%

Resveratrol and Immune Cells: A Link to Improve Human Health

et al. 2022

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The use of polyphenols as adjuvants in lowering risk factors for various debilitating diseases has been investigated in recent years due to their possible antioxidant action. Polyphenols represent a fascinating and relatively new subject of research in nutraceuticals and nutrition, with interest rapidly expanding since they can help maintain health by controlling metabolism, weight, chronic diseases, and cell proliferation. Resveratrol is a phenolic compound found mostly in the pulp, peels, seeds, and stems of red grapes. It has a wide variety of biological actions that can be used to prevent the beginning of various diseases or manage their symptoms. Resveratrol can influence multiple inflammatory and non-inflammatory responses, protecting organs and tissues, thanks to its interaction with immune cells and its activity on SIRT1. This compound has anti-inflammatory, antioxidant, anti-apoptotic, neuroprotective, cardioprotective, anticancer, and antiviral properties, making it a potential adjunct to traditional pharmaceutical therapy in public health. This review aims to provide a comprehensive analysis of resveratrol in terms of active biological effects and mechanism of action in modifying the immune cellular response to promote human psychophysical health.

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“…Different types of dendritic cells can be detected in the skin under both physiological and pathological conditions [ 60 , 61 ]. These cells can act as antigen-presenting cells (APCs), but also as an important source of chemical mediators of inflammation, such as TNF-α and IL-23 [ 62 ].…”

Section: Cell Types Involved In the Pathogenesis Of Psoriasismentioning

confidence: 99%

Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?

et al. 2022

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Psoriasis is one of the most widespread chronic inflammatory skin diseases, affecting about 2%–3% of the worldwide adult population. The pathogenesis of this disease is quite complex, but an interaction between genetic and environmental factors has been recognized with an essential modulation of inflammatory and immune responses in affected patients. Psoriatic plaques generally represent the clinical psoriatic feature resulting from an abnormal proliferation and differentiation of keratinocytes, which cause dermal hyperplasia, skin infiltration of immune cells, and increased capillarity. Some scientific pieces of evidence have reported that psychological stress may play a key role in psoriasis, and the disease itself may cause stress conditions in patients, thus reproducing a vicious cycle. The present review aims at examining immune cell involvement in psoriasis and the relationship of depression and stress in its pathogenesis and development. In addition, this review contains a focus on the possible use of natural products, thus pointing out their mechanism of action in order to counteract clinical and psychological symptoms.

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Expression of VAChT and 5-HT in Ulcerative colitis dendritic cells

Cited by 32 publications

References 44 publications

Histological and Chemical Analysis of Heavy Metals in Kidney and Gills of Boops boops: Melanomacrophages Centers and Rodlet Cells as Environmental Biomarkers

Histological and Chemical Analysis of Heavy Metals in Kidney and Gills of Boops boops: Melanomacrophages Centers and Rodlet Cells as Environmental Biomarkers

Resveratrol and Immune Cells: A Link to Improve Human Health

Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?

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