Expression of tumor necrosis factor-alpha–converting enzyme and tumor necrosis factor-alpha in human myocarditis

Abstract

These findings indicate that the expression of TNF-alpha and TACE may have important implications in the pathogenesis of myocarditis and may influence advanced cardiac dysfunction in myocarditis.

Transmembrane proteases in cell growth and invasion: new contributors to angiogenesis?

“…TACE and DPPIV are overexpressed in myocarditis (Satoh et al, 2000;Schonermarck et al, 2000). Endothelial ACE and macrophage MT1-MMP are overexpressed in advanced stages of atherosclerosis (Rajavashisth et al, 1999;Phillips and Kagiyama, 2002).…”

Differential regulation of tumor necrosis factor-α-converting enzyme and angiotensin-converting enzyme by type I and II interferons in human normal and leukemic myeloid cells

“…The cDNAs for human b 2 -microglobulin, ACE and TACE were amplified by PCR, and primers were designed according to published sequences (Costerousse et al, 1993;Satoh et al, 2000;Sanceau et al, 2002). b 2 -Microglobulin cDNA (165 bp) was amplified using the sense primer 5 0 -CAT CCA GCG TAC TCC AAA GA-3 0 and the antisense primer 5 0 -GAC AAG TCT GAA TGC TCC AC-3 0 .…”

CD34+ cell mobilization and upregulation of myocardial cytokines in a rabbit model of myocardial ischemia

“…Another such cytokine, tumor necrosis factor-alpha (TNFα), is a cytokine with pleiotropic biological effects and plays an important role in inflammatory reactions. TNFα plays a role in many myocardial diseases such as acute myocardial infarction (AMI) [14,15], myocarditis [16,17], dilated cardiomyopathy [18], and congestive heart failure (CHF) [19]. In addition, it is thought to induce apoptosis in cardiomyocytes [20] In fact, inflammation is currently thought to be a major contributor to AMI [21].…”