Transmembrane proteases in cell growth and invasion: new contributors to angiogenesis?

Bauvois, Brigitte

doi:10.1038/sj.onc.1207124

Cited by 151 publications

(124 citation statements)

References 167 publications

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“…17 These cells were diffusely positive for other markers of endothelia, including von-Willebrand domains 1 and 2 [18][19] and ACE. 20 They were found lining the vessel walls of the newly formed woven bone. This observation is of importance because it indicates that a process of vasculogenesis takes place in vitro within the newly synthesized tissue.…”

Section: Resultsmentioning

confidence: 99%

Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation

d’Aquino¹,

Graziano²,

et al. 2007

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Stromal stem cells from human dental pulp (SBP-DPSCs) were used to study osteogenic differentiation in vitro and in vivo. We previously reported that SBP-DPSCs are multipotent stem cells able to differentiate into osteoblasts, which synthesize threedimensional woven bone tissue chips in vitro. In this study, we followed the temporal expression pattern of specific markers in SBP-DPSCs and found that, when differentiating into osteoblasts, they express, besides osteocalcin, also flk-1 (VEGF-R2). In addition, 30% of them expressed specific antigens for endothelial cells, including CD54, von-Willebrand (domain 1 and 2), CD31 (PECAM-1) and angiotensin-converting enzyme. Interestingly, we found endotheliocytes forming vessel walls, observing that stem cells synergically differentiate into osteoblasts and endotheliocytes, and that flk-1 exerts a pivotal role in coupling osteoblast and endotheliocyte differentiation. When either SBP-DPSCs or bone chips obtained in vitro were transplanted into immunocompromised rats, they generated a tissue structure with an integral blood supply similar to that of human adult bone; in fact, a large number of HLA-1 þ vessels were observed either within the bone or surrounding it in a periosteal layer. This study provides direct evidence to suggest that osteogenesis and angiogenesis mediated by human SBP-DPSCs may be regulated by distinct mechanisms, leading to the organization of adult bone tissue after stem cell transplantion.

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Section: Resultsmentioning

confidence: 99%

Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation

d’Aquino¹,

Graziano²,

et al. 2007

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“…Given the importance of TACE as an important regulator of several key steps during angiogenesis, 18 we assessed the role of TACE in the pathological neovascularization induced by SS Abs. In anti-Ro/ SSA Abs-treated SGEC, we inhibited VEGF-A expression through the use of a specific anti-human VEGF-A monoclonal antibody (mAb).…”

Section: Tace Is Involved In Vegf-a-dependent Angiogenesis Induced Bymentioning

confidence: 99%

Sjögren’s syndrome pathological neovascularization is regulated by VEGF-A-stimulated TACE-dependent crosstalk between VEGFR2 and NF-κB

et al. 2012

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“…The transmembrane metalloproteases angiotensinconverting enzyme (ACE/CD143) and tumor necrosis factor-a (TNF-a)-converting enzyme (TACE/ADAM-17/CD156) are considered as useful markers in some inflammatory and tumoral diseases (Bauvois, 2004). Overexpression of ACE is observed in breast, lung and gastric cancer (Bauvois, 2004;Rocken et al, 2005), whereas TACE increase has been associated with prostate cancer (Bauvois, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Overexpression of ACE is observed in breast, lung and gastric cancer (Bauvois, 2004;Rocken et al, 2005), whereas TACE increase has been associated with prostate cancer (Bauvois, 2004). Both enzymes are expressed by a variety of cell types (Bauvois, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Differential regulation of tumor necrosis factor-α-converting enzyme and angiotensin-converting enzyme by type I and II interferons in human normal and leukemic myeloid cells

et al. 2006

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The transmembrane metalloproteases angiotensin-converting enzyme (ACE) and tumor necrosis factor-a (TNF-a)-converting enzyme (TACE/ADAM-17) have been associated with inflammation, cancer progression and angiogenesis. Few investigations into the regulation of these enzymes by physiological stimuli have been reported. In this study, we investigated the influence of interferons (IFNs) type I (a, b) and II (c) on ACE and TACE expression of human leukemic NB4 cells and monocytes.We assessed the expression of proteases by reverse transcriptase-polymerase chain reaction, enzyme-linked immunosorbent assay and immunofluorescence analyses. IFNc, but not type I IFNs, upregulated membrane ACE in a dose-and time-dependency and this was reflected by the increase of ACE enzymatic activity and ACE mRNA. ACE upregulation was dependent on protein synthesis. Treatment of the interferon responsive factor 1 (IRF1)-unresponsive HepG2 cell line with IFNc did not affect ACE expression, thus suggesting the participation of the IRF1 signaling pathway in IFNc-mediated ACE upregulation in myeloid cells. In contrast, both types of IFNs, in a dose-and time-dependent manner, downregulated surface TACE without affecting TACE transcript. Soluble TACE was not detected in the medium of IFN-treated cells. IFNc-mediated decrease of surface TACE in NB4 cells was reversible, and correlated with an increase in intracellular TACE, suggesting that cell surface TACE was internalized in response to IFNs. These findings, showing the presence of IFN-dependent controlled mechanisms by which ACE and TACE levels are regulated in human normal and leukemic myeloid cells, may have implications in the context of current investigations on the therapeutic potential of IFNs.

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Transmembrane proteases in cell growth and invasion: new contributors to angiogenesis?

Cited by 151 publications

References 167 publications

Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation

Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation

Sjögren’s syndrome pathological neovascularization is regulated by VEGF-A-stimulated TACE-dependent crosstalk between VEGFR2 and NF-κB

Differential regulation of tumor necrosis factor-α-converting enzyme and angiotensin-converting enzyme by type I and II interferons in human normal and leukemic myeloid cells

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