Expression of Transient Receptor Potential Channel of Melastatin number 8 (TRPM8) in Non- Melanoma Skin Cancer: A Clinical and Immunohistochemical study

Hemida, Aiat Shaban; Hammam, M. A.; Heriz, Nahla Abd Elslam Mohamed; Shehata, Wafaa Ahmed

doi:10.1080/15321819.2021.1918709

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…The evaluation of TRPM8 expression in both prostate normal and pathological tissues, both primary and metastatic secondary tumors, also indicated a higher expression in malignant lesions, especially in the advanced phases of the disease, reinforcing TRPM8 as a prostate biomarker [97]. Similar upregulation of TRPM8 was measured in cutaneous squamous cell carcinoma (SCC), a type of non-melanoma skin cancer (NMSC), while in basal cell carcinoma (BBC) tumors, this channel showed reduced expression [98]. The implication of different types of TRP channels in brain malignant tumors, glioma and glioblastoma, has been reviewed by G. Chinigó, and coworkers [99].…”

Section: Trpm8 Distribution and Pathological Implicationmentioning

confidence: 64%

TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation

Izquierdo

Martı́n-Martı́nez

Gómez-Monterrey

et al. 2021

IJMS

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The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated by low temperatures (>10, <28 °C), but also a polymodal ion channel, stimulated by voltage, pressure, cooling compounds (menthol, icilin), and hyperosmolarity. An increased number of experimental results indicate the implication of TRPM8 channels in cold thermal transduction and pain detection, transmission, and maintenance in different tissues and organs. These channels also have a repercussion on different kinds of life-threatening tumors and other pathologies, which include urinary and respiratory tract dysfunctions, dry eye disease, and obesity. This compendium firstly covers newly described papers on the expression of TRPM8 channels and their correlation with pathological states. An overview on the structural knowledge, after cryo-electron microscopy success in solving different TRPM8 structures, as well as some insights obtained from mutagenesis studies, will follow. Most recently described families of TRPM8 modulators are also covered, along with a section of molecules that have reached clinical trials. To finalize, authors provide an outline of the potential prospects in the TRPM8 field.

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Section: Trpm8 Distribution and Pathological Implicationmentioning

confidence: 64%

TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation

Izquierdo

Martı́n-Martı́nez

Gómez-Monterrey

et al. 2021

IJMS

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“…TRPM8 is the most studied TRP channel, because, out of all the family members, it has the highest levels of expression in different cancer types such as prostate cancer, colon cancer, breast cancer, melanoma, and PDAC [ 28 , 29 , 30 , 31 ]. The functions of TRPM8 are described mainly in relation to calcium homeostasis; as a second messenger, it regulates migration, proliferation, and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

The Association between TRP Channels Expression and Clinicopathological Characteristics of Patients with Pancreatic Adenocarcinoma

Chelaru

Chiosa

Sorop

et al. 2022

IJMS

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Pancreatic adenocarcinoma (PDAC) has low survival rates worldwide due to its tendency to be detected late and its characteristic desmoplastic reaction, which slows the use of targeted therapies. As such, the discovery of new connections between genes and the clinicopathological parameters contribute to the search for new biomarkers or targets for therapy. Transient receptor potential (TRP) channels are promising tools for cancer therapy or markers for PDAC. Therefore, in this study, we selected several genes encoding TRP proteins previously reported in cellular models, namely, Transient Receptor Potential Cation Channel Subfamily V Member 6 (TRPV6), Transient receptor potential ankyrin 1 (TRPA1), and Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), as well as the TRPM8 Channel Associated Factor 1 (TCAF1) and TRPM8 Channel Associated Factor 2 (TCAF2) proteins, as regulatory factors. We analyzed the expression levels of tumors from patients enrolled in public datasets and confirmed the results with a validation cohort of PDAC patients enrolled in the Clinical Institute Fundeni, Romania. We found significantly higher expression levels of TRPA1, TRPM8, and TCAF1/F2 in tumoral tissues compared to normal tissues, but lower expression levels of TRPV6, suggesting that TRP channels have either tumor-suppressive or oncogenic roles. The expression levels were correlated with the tumoral stages and are related to the genes involved in calcium homeostasis (Calbindin 1 or S100A4) or to proteins participating in metastasis (PTPN1). We conclude that the selected TRP proteins provide new insights in the search for targets and biomarkers needed for therapeutic strategies for PDAC treatment.

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“…In prostate cancer, TRPM8 androgen-dependent overexpression seems to be required for cancer cell survival (Lunardi et al, 2021;Zhang & Barritt, 2004), and TRPM8 has been proposed as a prognostic marker in such disease (Zhang & Barritt, 2004, 2006. The aberrant expression of TRPM8 has been also found in many other cancers (Hemida et al, 2021;Kijpornyongpan et al, 2014;Ouadid-Ahidouch et al, 2013;Xu et al, 2021;Yee et al, 2012). Either activation (by increasing cytosolic Ca 2+ levels) or antagonism/desensitization (by decreasing cytosolic Ca 2+ levels) of TRPM8 (Zhang & Barritt, 2006) has been shown to affect in vitro cell growth and/or survival (Huang et al, 2020;Li et al, 2009;Okamoto et al, 2012;Yee, 2015).…”

Section: Discussionmentioning

confidence: 99%