Expression of transforming growth factor‐β after different non‐invasive facial rejuvenation modalities

El‐Domyati, Moetaz; El‐Ammawi, Tarek S.; Medhat, Walid; Moawad, Osama; Mahoney, Mỹ G.; Uitto, Jouni

doi:10.1111/ijd.12435

Cited by 29 publications

(24 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These increases trigger TGF-β, to promote the expression of type I and XV collagen and chondroitin 6-sulfate, thus promoting fiber formation. TGF-β is reported to be increased with Nd:YAG 1320 nm and Er:YAG 2940 nm mini-peel treatments but is not increased with intense pulsed light or mesotherapy treatment [17]. A cream containing TGF-β and ascorbic acid improves the appearance of wrinkles [18].…”

Section: Discussionmentioning

confidence: 99%

Utility of the Teslar Facial Massager for Skin Elasticity and the Mechanism of its Effects

et al. 2018

View full text Add to dashboard Cite

The Teslar is a facial massager that emits a weak electric current, where users have reported a beneficial effect on skin elasticity with continued use. Accordingly, we conducted a clinical utility study and a comprehensive gene analysis, with cultured human fibroblasts to investigate the utility and mechanism of this treatment. In this clinical utility study, we found significant improvement in skin elasticity in Teslar treatments, compared to controls after two weeks of treatment. In cell experiments, we found that adenosine triphosphate synthesis and collagen contraction were promoted in fibroblasts cultured in type I collagen gel, following Teslar treatment. We considered that Teslar treatment exerted a structurally regenerative effect on the dermal matrix, based on the results of GeneChip ® Expression Analysis. In particular, we demonstrated that Teslar treatment promotes type I collagen mRNA expression and fibulin-5/DANCE (Developmental arteries and neural crest EGF (epidermal growth factor)-like) mRNA expression and protein levels, which are reduced with aging. We also found increases in LTBP-3 (Latent TGF-β binding protein-3) and CSPG4 (Chondroitin sulfate proteoglycan 4) mRNA expression levels. Based on these results, we considered that Teslar treatment promoted dermal regeneration and recovery of skin elasticity.

show abstract

Section: Discussionmentioning

confidence: 99%

Utility of the Teslar Facial Massager for Skin Elasticity and the Mechanism of its Effects

et al. 2018

View full text Add to dashboard Cite

show abstract

“…TGF-β is the master regulator of the ECM. It is known to stimulate the fibroblasts in the dermis to synthesize several proteins such as collagen, the main constituent of dermal ECM [22]. Among the most prominent are collagen type I (80-85%) and type III (10-15%), which provide strength and resilience to the skin [23].…”

Section: Discussionmentioning

confidence: 99%

“…However, the aging process affects TGF-β levels and activity. TGF-β has been shown to be lower both in in vitro aged fibroblasts, and in vivo aged skin [22,27], as well as in chronological skin aging and even more so in photo-aging. Thus, there is a need to restore the missing activity in aged skin conditions.…”

Section: Discussionmentioning

confidence: 99%

Anti-Skin-Aging Activity of a Standardized Extract from Panax ginseng Leaves In Vitro and In Human Volunteer

et al. 2017

View full text Add to dashboard Cite

Ginseng leaves contain high saponin composition and content, but are used less often than the root part. To develop a use for the leaves that exploits their properties, we studied ginseng leaves as the raw material of anti-aging cosmetics. This study highlights an assessment of the cellular factivity and clinical efficacy of ginseng leaf extract, providing necessary information relevant to the development of new cosmetic products. Panax ginseng leaf purified extracts (PGLE) were shown to have high contents of Rb3 and Rb2. Rb3, the major chemical components of PGLE, promoted collagen synthesis though the activation of transforming growth factor-β (TGF-β) in human skin fibroblast cells. In addition, the possibility of PGLE as an anti-skin-aging agent has also been clinically validated. Our analysis of the crow's feet wrinkle showed that there was a decrease in the depth of deep furrows in the region of interest (RI) treated with PGLE lotion over an eight-week period. Based on these results, we suggest the possibility that PGLE, having high levels of Rb3, be considered as an attractive, wrinkle-reducing candidate for topical application.

show abstract

“…The induction of TGF-β1 was epidermal and limited to the upper differentiated layers of the epidermis [30]. However, another study by El-Domyati showed no significant differences (p ﹤ 0.05) in TGF-β1 protein expression levels among the IPL-treated and the control groups (baseline [before treatment]; end of treatment [after 3 months]; posttreatment [6 months after the start of treatment]) [31], which did not concord with Ali's study. This may be due to the different time points to obtain skin biopsies (the former detected the TGF-β1 7 days after IPL irradiation, whereas the latter obtained the biopsies 3 and 6 months after IPL irradiation) and different IPL devices and parameters.…”

Section: In Vivo Effects Of Ipl On the Skinmentioning

confidence: 97%

Intense Pulsed Light Therapy

Gu¹,

Liu²,

Liu³

2017

Photomedicine - Advances in Clinical Practice

View full text Add to dashboard Cite

Intense pulsed light (IPL) is one of the most effective nonablative approaches to treat skin photoaging. The broad range of wavelengths (500-1200 nm) emitted from IPL devices effectively target both melanin and hemoglobin in the skin. Numerous trials show the effectiveness and compatibility of IPL devices in a variety of skin conditions, especially in cosmetic indications such as hypertrichosis and telangiectasias. Compared with the wide clinical use of IPL, the biochemical and molecular mechanism is not clear. Both in vivo and in vitro studies demonstrate that IPL could increase the production of extracellular matrix, promote the proliferation of fibroblasts, and increase the secretion of TGF-β and matrix metalloproteinases, which play important roles in the photorejuvenation effects of IPL. However, investigations regarding the detailed underlying mechanism are necessary.

show abstract

Expression of transforming growth factor‐β after different non‐invasive facial rejuvenation modalities

Cited by 29 publications

References 30 publications

Utility of the Teslar Facial Massager for Skin Elasticity and the Mechanism of its Effects

Utility of the Teslar Facial Massager for Skin Elasticity and the Mechanism of its Effects

Anti-Skin-Aging Activity of a Standardized Extract from Panax ginseng Leaves In Vitro and In Human Volunteer

Intense Pulsed Light Therapy

Contact Info

Product

Resources

About