Expression of the <i>prolactin‐indudble protein (PIP/GCDFP15)</i> gene in benign epithelium and adenocarcinoma of the prostate

Tian, Wei; Osawa, Motoki; Horiuchi, Hidekazu; Tomita, Yoshihiko

doi:10.1111/j.1349-7006.2004.tb03238.x

Cited by 29 publications

(17 citation statements)

References 29 publications

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“…Prolactin-inducible protein (PIP) is another protein expressed in seminal fluid (among other fluids) that has been linked to prostate cancer. This gene is highly expressed in prostate carcinoma relative to benign tissue [79]. Diazapim binding inhibitor shows androgen-regulated patterns of expression and is highly expressed in prostate cancer cell-lines in vitro [80].…”

Section: Mta1mentioning

confidence: 99%

The androgen receptor and prostate cancer: A role for sexual selection and sexual conflict?

Summers

Crespi

2008

Medical Hypotheses

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Summary We propose and evaluate the hypothesis that the CAG repeat region of the androgen receptor represents a locus of antagonistic pleiotropy in the context of sexual selection and sexual conflict. Short repeats are associated with increased transactivation of the androgen receptor at the molecular level, and increased fertility at the phenotypic level. However, short repeats are also associated with increased risk of prostate cancer, and with more aggressive forms of the disease. The somatic evolution of cancer cell lineages also shows a repeated pattern of shortening of the CAG repeat in association with cancer progression, apparently as a result of positive selection among cell lineages. We further postulate that other genes associated with prostate cancer are likely to mediate antagonistic pleiotropy in the context of sexual selection and sexual conflict. A key prediction of this hypothesis is that the genes mediating antagonistic pleiotropy will show historical evidence of positive selection, particularly in the context of sexual conflict. Previous research on the molecular evolution of specific genes associated with prostate cancer supports this prediction, and we suggest further critical tests of the role for genomic conflicts and tradeoffs in the evolution of cancer risk.

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Section: Mta1mentioning

confidence: 99%

The androgen receptor and prostate cancer: A role for sexual selection and sexual conflict?

Summers

Crespi

2008

Medical Hypotheses

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“…Despite being highly breast-specific, PIP has also been detected, although generally at low levels, in various other tissues (Mazoujian et al 1983, Haagensen et al 1990, Clark et al 1999, Liu et al 2004, Tian et al 2004.…”

Section: Pipmentioning

confidence: 99%

Significance, detection and markers of disseminated breast cancer cells

Lacroix¹

2006

Endocr Relat Cancer

258

220

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The development of distant metastases is the major cause of death from breast cancer. In order to predict and prevent tumour spreading, many attempts are being made to detect small numbers of tumour cells that have shed from the primary lesions and have moved to lymph nodes, blood or bone marrow. This article presents the advantages and the limitations of techniques used for disseminated tumour cells (DTC) detection. DTC markers are listed and the most currently used of them (KRT19, CEACAM5, TACSTD1, MUC1, EGFR, ERBB2, SCGB2A2, SCGB2A1, SCGB1D2, PIP, SBEM, TFF1, TFF3, ANKRD30A, SPDEF, ESR1, SERPINB5 and GABRP) are discussed, notably on the basis of recent data on breast tumour portraits (luminal epithelial-like, basal/myoepithelial-like and ERBB2). The significance of DTC for the prognosis and prediction of response to therapy is examined. DTC viability, the notion of cell dormancy and the concept of breast cancer stem cells are also discussed.

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“…In particular, multiple COBRA1-regulated genes have been associated with breast cancer. These include APOD (Lopez-Boado et al, 1994;Blais et al, 1995;Rassart et al, 2000), CLDN1 (Kramer et al, 2000;Hoevel et al, 2002;Morin, 2005;Tokes et al, 2005), MGP (Chen et al, 1990;Sheikh et al, 1993;Hirota et al, 1995), GAGEs (Mashino et al, 2001;Duan et al, 2003), MCM2 (Gonzalez et al, 2003;Moggs et al, 2005;Shetty et al, 2005), PIP (Pagani et al, 1994;Clark et al, 1999;Carsol et al, 2002;Tian et al, 2004), TIMP1 (Nakopoulou COBRA1 regulates clustered gene expression SE Aiyar et al et al, 2003;Wu¨rtz et al, 2005), WISP2 (Banerjee et al, 2003) and TFF3 (Xu et al, 2005).…”

Section: Whole-genome Analysis Of Cobra1-regulated Genesmentioning

confidence: 99%

Regulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells

et al. 2006

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Expression of the prolactin‐indudble protein (PIP/GCDFP15) gene in benign epithelium and adenocarcinoma of the prostate

Abstract: ross cystic disease fluid protein 15 (GCDFP15) is a 15-to 17-kDa glycoprotein isolated from human breast cystic fluid.

Cited by 29 publications

References 29 publications

The androgen receptor and prostate cancer: A role for sexual selection and sexual conflict?

The androgen receptor and prostate cancer: A role for sexual selection and sexual conflict?

Significance, detection and markers of disseminated breast cancer cells

Regulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells

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