Significance, detection and markers of disseminated breast cancer cells

Lacroix, Marc

doi:10.1677/erc-06-0001

Cited by 258 publications

(232 citation statements)

References 232 publications

(148 reference statements)

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“…The potential diagnostic relevance of BASE is supported by the predicted secretion of the protein, as a correlation between the levels of the breast cancer marker HER2/neu (c-ERBB-2) in saliva and nipple aspirates and breast cancer in women has been shown already (29,30). Detection of breast cancer markers in saliva or nipple aspirates opens the possibility of a noninvasive and inexpensive diagnostic tool for early detection of breast tumors and improved treatment response.…”

Section: Discussionmentioning

confidence: 99%

Estrogen Induces Repression of the Breast Cancer and Salivary Gland Expression Gene in an Estrogen Receptor α–Dependent Manner

et al. 2008

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The focus of this study is on the expression and regulation of the estrogen-regulated breast cancer and salivary gland expression (BASE) gene that may function as a breast cancer marker. In MCF7 cells, BASE is repressed by estrogen in an estrogen receptor A (ERA)-dependent manner. Promoter analysis of the BASE gene led to the identification of a 2-kb upstream enhancer that harbors binding sites for ERA and FoxA1. The recruitment of both ERA and FoxA1 to this region was shown by chromatin immunoprecipitation analysis. Furthermore, mutation studies and knockdown experiments show a clear separation between gene expression mediated by FoxA1 and ERA-dependent gene regulation. Additionally, we provide information on BASE expression in human breast tumor samples.

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Section: Discussionmentioning

confidence: 99%

Estrogen Induces Repression of the Breast Cancer and Salivary Gland Expression Gene in an Estrogen Receptor α–Dependent Manner

et al. 2008

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“…The basal subtype of breast cancer is usually associated with a poor progno- sis, 26 whereas the luminal subtype generally has a more favorable prognosis. 27 Genes associated with the luminal subtype of breast cancer, such as FOXA1, 28 SCGB2A1, 29 and SCGB1D2, 29 were found to be down-regulated in the GI-AGR and GI-BRN cells. We validated the expression of several of these genes, including FOXA1, MSX1, GABRP, and BNC1, using RT-PCR analysis ( Figure 4B).…”

Section: Comparative Transcriptional Profiling Of Gi-101a Gi-agr Anmentioning

confidence: 99%

Selection of Brain Metastasis-Initiating Breast Cancer Cells Determined by Growth on Hard Agar

Guo

Fan

Zhang

et al. 2011

The American Journal of Pathology

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An approach that facilitates rapid isolation and characterization of tumor cells with enhanced metastatic po-The vast majority of cancer deaths result from progressive growth of metastases that are resistant to conventional therapies. 1 Metastases originate from a selected subpopulation of cells that reside in a biologically heterogeneous primary tumor. 2,3 Results from experimental 4 and clinical 5 examinations indicate that most metastases are clonal in origin and that the metastatic process is highly selective. 6 Studies have also shown profound differences between local and disseminated cancers, 7 suggesting that information on primary tumors alone may not be sufficient to determine optimal therapeutic interventions. For this reason, researchers have directed considerable effort toward improving understanding of the molecular phenotypes of metastasis-initiating tumor cells.One widely used experimental approach to isolate populations of tumor cells with enhanced metastatic potential is an in vivo selection process in which tumor cells are implanted into syngeneic or immunodeficient mice and metastasis is allowed to occur. Tumor cells from the resultant metastatic lesions can be isolated and expanded to establish cell sublines, some of which may have higher metastatic capacity than the parental tumorcell population. 8 Comparative gene expression profiling of parental tumor cells and their metastatic subpopulations has yielded invaluable information regarding the genetic determinants critical for organ-specific metastasis. 9 For example, Kang et al 10 compared the transcriptional profiles of parental MDA-231 human breast cancer cells with those of a bone-colonizing variant of this cell line and reported the underlying gene expression signature required for organ tropism to bone. Investigators used a similar approach to identify genes whose expression is critical for metastasis of breast cancer cells to the brain 11 and lungs. 12 Nevertheless, although this in vivo selection technique has provided new insight into the cellular and molecular mechanisms that control site-specific metastasis, there are some disadvantages. Perhaps the principal drawback of in vivo selection is that it can be time-consuming,

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“…Staging in breast cancer is a fundamental parameter for prognosis. Breast cancer dissemination normally involves a succession of clinical and pathological stages, starting with breast carcinoma in situ, progressing to invasive lesions and culminating in metastatic disease [25]. The frequency of ovarian metastases in breast cancer patients can vary between 13.2 % and 37.8 %, depending on breast cancer type and on the published clinical series [24,35].…”

Section: Breast Metastasis In Ovarian Tissuementioning

confidence: 99%

“…Quantitative PCR was used to detect and characterize potential metastatic cells through identification of genetic features associated with tumor cells. A review of the literature by Lacroix [25] on the detection of metastatic cells by qPCR processing in lymph nodes and peripheral blood from patients with breast cancer defined some markers with low and high breast specificity. MGB1 and MGB2, lipophilin B, PIP (or GCDFP-15), and several others were classified as markers with high breast specificity.…”

Section: Introductionmentioning

confidence: 99%

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

Luyckx

Durant

Camboni

et al. 2013

J Assist Reprod Genet

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Significance, detection and markers of disseminated breast cancer cells

Cited by 258 publications

References 232 publications

Estrogen Induces Repression of the Breast Cancer and Salivary Gland Expression Gene in an Estrogen Receptor α–Dependent Manner

Estrogen Induces Repression of the Breast Cancer and Salivary Gland Expression Gene in an Estrogen Receptor α–Dependent Manner

Selection of Brain Metastasis-Initiating Breast Cancer Cells Determined by Growth on Hard Agar

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

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