Expression of the heparin-binding growth factor midkine and its receptor, Ptprz1, in adult rat pituitary

Fujiwara, Ken; Horiguchi, Kotaro; Maliza, Rita; Tofrizal, Alimuddin; Batchuluun, Khongorzul; Ramadhani, Dini; Syaidah, Rahimi; Tsukada, Takehiro; Azuma, Morio; Kikuchi, Motoshi; Yashiro, Takashi

doi:10.1007/s00441-014-2073-8

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…1c, g). We previously detected MK mRNA in FS cells [8]. In the present study, MK mRNA was detected in some RALDH1-immunopositive cells (Fig.…”

Section: In Situ Hybridization and Immunohistochemistrysupporting

confidence: 76%

“…In a previous study, we reported that the MK receptor Ptprz1 was expressed in somatotrophs and corticotrophs in rat anterior pituitary gland [8]. We hypothesized that MK produced in FS cells acts locally on these hormone-producing cells via PTPRZ1 in the anterior pituitary.…”

Section: Resultsmentioning

confidence: 92%

“…Quantitative real-time PCR and RT-PCR was performed as described in our previous report [8,13]. The primers used to amplify cDNA fragments were listed in Table 1.…”

Section: Real-time Pcr and Reverse Transcription (Rt)-pcrmentioning

confidence: 99%

“…MK promotes growth, survival, and migration of various cells and has roles in neurogenesis and epithelial mesenchymal interactions during organogenesis [7]. Our previous study showed that FS cells produce MK in the adult rat anterior pituitary gland [8]. Moreover, the MK receptor protein tyrosine phosphatase zeta 1 (Ptprz1) is expressed in hormone-producing cells.…”

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confidence: 99%

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Effect of retinoic acid on midkine gene expression in rat anterior pituitary cells

et al. 2017

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“…1c, g). We previously detected MK mRNA in FS cells [8]. In the present study, MK mRNA was detected in some RALDH1-immunopositive cells (Fig.…”

Section: In Situ Hybridization and Immunohistochemistrysupporting

confidence: 76%

Section: Resultsmentioning

confidence: 92%

“…Quantitative real-time PCR and RT-PCR was performed as described in our previous report [8,13]. The primers used to amplify cDNA fragments were listed in Table 1.…”

Section: Real-time Pcr and Reverse Transcription (Rt)-pcrmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of retinoic acid on midkine gene expression in rat anterior pituitary cells

et al. 2017

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“…GH and midkine (MDK) relation should be investigated Midkine (MK), a heparin-binding growth factor that seems to play an important role in arteriogenesis by mediating NO synthases and increasing the bioavailability of VEGFA [186], has also been related with GH, as expression of MK and its receptors have been detected in somatotrophs of both embryonic and adult rats, favoring the development of pituitary gland [187] and acting as a regulator of its function in the adult. MK seems to be secreted by follicle stimulating cells, controlling GH production from GH cells in a paracrine way via protein tyrosine phosphatase receptor-type Z (Ptprz1) [188]. MK is involved in the process of mechanosensing to SSF, as its receptor has an identical structure of sensors for laminar shear stress and induces a very similar signal cascades [189].…”

Section: Gh and Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

Why Should Growth Hormone (GH) Be Considered a Promising Therapeutic Agent for Arteriogenesis? Insights from the GHAS Trial

Caicedo¹,

Devesa²,

Álvarez³

et al. 2019

Preprint

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Despite the important role that the GH/IGF-I axis plays in vascular homeostasis, these kind of growth factors barely appear in articles addressing the neovascularization process. Currently, the vascular endothelium has turned to be considered as an authentic gland of internal secretion due to the wide variety of released factors and functions with local effect, including the paracrine/autocrine production of GH or IGF-I, for which the endothelium has specific receptors. In this comprehensive review, it will be described the evidence involving these proangiogenic hormones in arteriogenesis dealing with the arterial occlusion and making of them a potential therapy. It will be analyzed all those elements triggering the local and systemic production of GH/IGF-I and their possible role both in physiological and pathological conditions. The whole evidence will be combined with important data from the GHAS trial, in which GH or placebo were administrated to patients suffering from critical limb ischemia with no option for revascularization. We postulate that GH, alone or in combination, should be considered as a promising therapeutic agent for helping in the approach of the ischemic disease.A normal embryonic development needs the formation of blood vessels [21]; after birth there is also the need of the formation of new blood vessels while growing, but also in some physiological processes such as the menstrual cycle in women and the development of the mammary gland during pregnancy [22], but apart from these situations, adult neovascularization rarely takes place and when it happens it is associated with pathological affectations, such as wounds, muscle injuries, fractures or hypoxia/ischemia. The question now would be: how does neovascularization occur in adults and what is the role of the GH / IGF-I system in it?As it seems logical, hypoxia is a very important stimulus for the growth of new blood vessels [23], triggering this growth through hypoxia-inducible factors (HIF) that act on the expression of proangiogenic factors, but also that of anti-angiogenic factors to achieve the perfect number and size of the vessels necessary to compensate for the lack of oxygen supply and to regenerate the tissue [23]. This is a clear and well-established fact for angiogenesis. However, when a progressive narrowing of the vascular lumen appears, preexisting collaterals will have to growth to compensate the lack of distal flow which is triggered in a totally different way. With independence of that, the stimulation of endothelial nitric oxide synthase (eNOS) that leads to the production of nitric oxide (NO) from the vascular endothelium seems to be the key mediator for both kind of reparative processes. NO is a potent vasodilator, therefore increasing blood supply to the zone affected by hypoxia/ischemia. This implies changes in the vascular tone, vasorelaxation and vasopermeability, which are affected in arteries suffering an atherosclerotic damage. Interestingly, GH activates the NO pathway [14,24] throughout direct mechanisms tha...

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Aldolase C is a novel molecular marker for folliculo-stellate cells in rodent pituitary

et al. 2020

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Expression of the heparin-binding growth factor midkine and its receptor, Ptprz1, in adult rat pituitary

Cited by 8 publications

References 20 publications

Effect of retinoic acid on midkine gene expression in rat anterior pituitary cells

Effect of retinoic acid on midkine gene expression in rat anterior pituitary cells

Why Should Growth Hormone (GH) Be Considered a Promising Therapeutic Agent for Arteriogenesis? Insights from the GHAS Trial

Aldolase C is a novel molecular marker for folliculo-stellate cells in rodent pituitary

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