Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma

Abstract

Extrahepatic bile duct carcinoma is one of the most extremely aggressive cancers with poor prognosis after curative resection. Syndecan-1 and E-cadherin are transmembrane glycoproteins, and have important roles in cell-cell adhesion and tumor progression. In this study, we examined 84 surgically resected cases of extrahepatic bile duct adenocarcinoma to clarify clinicopathological significance of syndecan-1/E-cadherin expression. Reduced expressions of syndecan-1 and Ecadherin were found in 69.0% (58/84) and 46.4% (39/84) of the bile duct carcinomas. Reduced syndecan-1 expression was correlated with lymphatic/venous/nervous invasion (P < 0.0001), and was associated with short overall survival (P = 0.0002). Reduced E-cadherin expression was correlated with lymphatic and nervous invasion (P = 0.008, P < 0.0001, respectively), and was associated with short overall survival (P = 0.0038). The results indicated that reduced syndecan-1/ E-cadherin expression may be good indicators of recurrence and prognosis in extrahepatic bile duct carcinoma.

Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP

“…However, there is significant controversy in clinical findings on the prognostic value of syndecan-1 in tumor progression. Epithelial syndecan-1 expression is reduced in several malignant tumors (Inki et al, 1994;Matsumoto et al, 1997;Nackaerts et al, 1997;Pulkkinen et al, 1997;Wiksten et al, 2001;Ohashi et al, 2009), but in breast cancer, increased expression has also been described. High syndecan-1 has been linked to poor prognosis (Barbareschi et al, 2003) as well as increased relapse-free survival (Loussouarn et al, 2008) in breast cancer.…”

Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer

“…It occurs with great frequency in Asian countries, and is one of the common causes of cancer death in Japan, with near to 17,000 deaths annually (2). The 5-year survival rate of EHBDCA, even after the surgical resection is poor, ranging from 20 to 45% (3)(4)(5).…”

Malignant tumours of gallbladder and extrahepatic bile ducts

“…Their reduced expression in EBDC is associated with lymphatic/perineural invasion and reduced survival. 48 Lastly, apomucins (MUC) appear to have prognostic relevance. Tumours with high MUC1 expression appear to correlate with infiltrative growth pattern, perineural invasion, dedifferentiation and poor prognosis.…”