Expression of <scp>N</scp>iban in renal interstitial fibrosis

Liu, Jishi; Qin, Jiao; Mei, Wenjuan; Zhang, Hao; Yuan, Qiongjing; Peng, Zhangzhe; Luo, Renna; Yuan, Xiangning; Huang, Ling; Tao, Ling

doi:10.1111/nep.12266

Cited by 12 publications

(14 citation statements)

References 33 publications

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“…Niban is overexpressed in several cancers and modulate cell death through regulation of its expression and phosphorylation [62][63][64][65][66]. The antiapoptotic activity of Niban is governed by Akt-dependent phosphorylation as it disrupts p53-containing protein complex under UV-stress [28] and experimental overexpression of the protein alone failed to diminished apoptosis in tumor cells [67]. Depending on the cell type and the nature of the stimuli, cytotoxic concentration of ATP either inhibits [68,69] or stimulates Akt phosphorylation [39,70].…”

Section: Discussionmentioning

confidence: 99%

P2X7R antagonism after subfailure overstretch injury of blood vessels reverses vasomotor dysfunction and prevents apoptosis

Luo

Feldman

McCallister

et al. 2017

Purinergic Signalling

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Human saphenous vein (HSV) is harvested and prepared prior to implantation as an arterial bypass graft. Injury and the response to injury from surgical harvest and preparation trigger cascades of molecular events and contribute to graft remodeling and intimal hyperplasia. Apoptosis is an early response after implantation that contributes the development of neointimal lesions. Here, we showed that surgical harvest and preparation of HSV leads to vasomotor dysfunction, increased apoptosis and downregulation of the phosphorylation of the anti-apoptotic protein, Niban. A model of subfailure overstretch injury in rat aorta (RA) was used to demonstrate impaired vasomotor function, increased extracellular ATP (eATP) release, and increased apoptosis following pathological vascular injury. The subfailure overstretch injury was associated with activation of p38 MAPK stress pathway and decreases in the phosphorylation of the anti-apoptotic protein Niban. Treatment of RA after overstretch injury with antagonists to purinergic P2X7 receptor (P2X7R) antagonists or P2X7R/pannexin (PanX1) complex, but not PanX1 alone, restored vasomotor function. Inhibitors to P2X7R and PanX1 reduced stretch-induced eATP release. P2X7R/PanX1 antagonism led to decrease in p38 MAPK phosphorylation, restoration of Niban phosphorylation and increases in the phosphorylation of the anti-apoptotic protein Akt in RA and reduced TNFα-stimulated caspase 3/7 activity in cultured rat vascular smooth muscle cells. In conclusion, inhibition of P2X7R after overstretch injury restored vasomotor function and inhibited apoptosis. Treatment with P2X7R/PanX1 complex inhibitors after harvest and preparation injury of blood vessels used for bypass conduits may prevent the subsequent response to injury that lead to apoptosis and represents a novel therapeutic approach to prevent graft failure.

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Section: Discussionmentioning

confidence: 99%

P2X7R antagonism after subfailure overstretch injury of blood vessels reverses vasomotor dysfunction and prevents apoptosis

Luo

Feldman

McCallister

et al. 2017

Purinergic Signalling

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“…Activin is a recently discovered member of the transforming growth factor (TGF)-β superfamily, and TGF-β, which is well recognised as an important factor for fibrosis, is a marker of transdifferentiation of tubular epithelial cells into fibroblasts. Activin can promote the differentiation of renal tubular epithelial cells, promote the proliferation of interstitial cells, and has a role in fibrosis of the renal interstitium [20]. It was shown that there was almost no expression of activin in the kidneys of healthy adults, and the expression of activin in renal tissue in patients with ischaemia-reperfusion injury was significantly increased [7].…”

Section: Discussionmentioning

confidence: 99%

Different Doses of <b><i>Tripterygium</i></b> Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids

Wang¹

2018

Kidney Blood Press Res

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Background/Aims: The aim of this study was to investigate the therapeutic effect of different doses of tripterygium glycosides (TG) in the treatment of diabetic nephropathy (DN). The effect of TG on blood lipids and safety were also evaluated. Methods: Sixty patients with type 2 DN were randomly divided into three groups (n=20 per group): low-dose (30 mg/day TG), double-dose (60 mg/day TG) and control (placebo) groups, all three times daily for 6 months. The levels of triglycerides, total cholesterol, urinary protein, plasma albumin and serum tumour necrosis factor (TNF)-α were compared between the three groups. Results: After treatment, urinary protein and TNF-α level significantly decreased in patients in the treatment groups, compared with the control group. This decrease was significantly larger in the double-dose group than in the low-dose group. However, there was no significant decrease in triglycerides and total cholesterol in the two treatment groups. Furthermore, plasma albumin was lower in the treatment groups than in the control group. Conclusion: The double dose of TG has improved clinical efficacy, compared with the low dose, and the same safety profile.

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“…However, it is well‐known that some members of the FAM129 proteins (to which BCNP1 or FAM129C belongs) such as Niban (FAM129A) are indeed involved in cancer. For example, Niban was found to be up‐regulated in renal carcinoma 2, 7, 8 in renal interstitial fibrosis 6, head and neck squamous cell carcinoma and squamous dysplasia 9, and also in thyroid tumours and Hashimoto's thyroiditis 10. Sun et al .…”

Section: Introductionmentioning

confidence: 99%

“…Many components of the PI3K signalling pathways are frequently altered in a broad spectrum of human cancers [5]. Currently, there are multiple clinical trials studying the role of inhibitors involving PI3K and other kinases in the signalling pathways in cancer [5,6].…”

Section: Introductionmentioning

confidence: 99%

The possible roles of B‐cell novel protein‐1 (BCNP1) in cellular signalling pathways and in cancer

Patel

Trivedi

Darie

et al. 2016

J Cellular Molecular Medi

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B‐cell novel protein‐1 (BCNP1) or Family member of 129C (FAM129C) was identified as a B‐cell‐specific plasma‐membrane protein. Bioinformatics analysis predicted that BCNP1 might be heavily phosphorylated. The BCNP1 protein contains a pleckstrin homology (PH) domain, two proline‐rich (PR) regions and a Leucine Zipper (LZ) domain suggesting that it may be involved in protein‐protein interactions. Using The Cancer Genome Atlas (TCGA) data sets, we investigated the correlation of alteration of the BCNP1 copy‐number changes and mutations in several cancer types. We also investigated the function of BCNP1 in cellular signalling pathways. We found that BCNP1 is highly altered in some types of cancers and that BCNP1 copy‐number changes and mutations co‐occur with other molecular alteration events for TP53 (tumour protein P53), PIK3CA (Phosphatidylinositol‐4,5‐Bisphosphate 3‐Kinase, Catalytic Subunit Alpha), MAPK1 (mitogen‐activated protein kinase‐1; ERK: extracellular signal regulated kinase), KRAS (Kirsten rat sarcoma viral oncogene homolog) and AKT2 (V‐Akt Murine Thymoma Viral Oncogene Homolog 2). We also found that PI3K (Phoshoinositide 3‐kinase) inhibition and p38 MAPK (p38 mitogen‐activated protein kinase) activation leads to reduction in phosphorylation of BCNP1 at serine residues, suggesting that BCNP1 phosphorylation is PI3K and p38MAPK dependent and that it might be involved in cancer. Its degradation depends on a proteasome‐mediated pathway.

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Expression of Niban in renal interstitial fibrosis

Abstract: Niban decreased in renal tubular cells of patients of obstructive nephropathy, UUO rats and TGF-β1 stimulated HK-2 cells. Suppressing Niban increases apoptosis in HK-2 cells. Niban may be associated with apoptosis of HK-2 cells.

Cited by 12 publications

References 33 publications

P2X7R antagonism after subfailure overstretch injury of blood vessels reverses vasomotor dysfunction and prevents apoptosis

P2X7R antagonism after subfailure overstretch injury of blood vessels reverses vasomotor dysfunction and prevents apoptosis

Different Doses of <b><i>Tripterygium</i></b> Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids

The possible roles of B‐cell novel protein‐1 (BCNP1) in cellular signalling pathways and in cancer

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