Expression of retinoid receptors in multiple cell lineages in the gastric mucosae of mice and humans

Karam, Sherif M.; Hassan, Wail M.; John, Rony

doi:10.1111/j.1440-1746.2005.04064.x

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Most of the results from experimental animal studies indicate that retinoids are effective in preventing or suppressing cancers. Most biological effects of retinoids are mediated through retinoid receptors; previous work has established that retinoid receptors are expressed in a variety of gastric cancer cell lines (Shyu et al, 1995;Liu et al, 1998;Jiang et al, 1999;Liu et al, 2001;Lin et al, 2004;Ye et al, 2004;Karam et al, 2005). However, the expression of retinoid receptors has hardly been investigated in clinical gastric cancer tissues.…”

Section: Discussionmentioning

confidence: 99%

Retinoid Receptors in Gastric Cancer: Expression and Influence on Prognosis

Chen²,

Ge³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Retinoic acid has been recognised as a pivotal compound in cell differentiation, proliferation and malignant transformation (Shyu et al., 1995;Tanaka and De Luca, 2009). Retinoids are natural and synthetic derivatives of retinol (vitamin A). The naturally occuring retinoids, all-trans retinoic acid, 9-cis retinoic acid and 13-cis retinoic acid, are generated from diet-derived retinol. Retinoids are ligands of cellular receptors of retinoic acid, including retinoic acid receptors (RARs) and retinoid X receptors (RXRs) who are members of the steroid and thyroid hormone receptor superfamily (Evans, 1998;Sun and Lotan, 2002). Each subtype of both retinoid receptor classes (RARa, RARβ, RARγ and RXRa, RXRβ, RXRγ respectively) is encoded by separate genes. Multiple isoforms of receptor subtypes exist as a result of

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Section: Discussionmentioning

confidence: 99%

Retinoid Receptors in Gastric Cancer: Expression and Influence on Prognosis

Chen²,

Ge³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…GC cell lines seem to be a relevant model since RARs seem to be expressed in a large variety of them [ 61 , 98 ].…”

Section: Atra On Gc Modelsmentioning

confidence: 99%

Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review

Bouriez

Giraud

Gronnier

et al. 2018

IJMS

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Gastric cancer (GC) is the third leading cause of cancer-related death worldwide with a five-year survival rate of around 25%, and 4% when diagnosed at a metastatic stage. Cancer stem cells (CSC) have recently been characterized as being responsible for resistance to radio/chemotherapies and metastasis formation, opening up perspectives for new targeted therapies. Those CSCs express biomarkers such as cluster of differentiation 44 (CD44) and display high aldehyde dehydrogenase activity that converts vitamin A-derived retinal into retinoic acids. All-trans retinoic acid (ATRA), which has pro-differentiating properties, has revolutionized the prognosis of acute promyelotic leukemia by increasing its remission rate from 15% to 85%. Recent studies have started to show that ATRA also has an anti-tumoral role on solid cancers such as GC. The purpose of this review is therefore to summarize the work that evaluated the effects of ATRA in GC and to evaluate whether its anti-cancerous action involves gastric CSCs targeting. It has been demonstrated that ATRA can block the cell cycle, enhance apoptosis, and decrease gastric CSCs properties in GC cell lines, tumorspheres, and patient-derived xenograft mice models. Therefore, retinoids and new synthetic retinoids seem to be a promising step forward in targeted therapy of gastric CSC in combination with existing chemotherapies. Future studies should probably focus on these points.

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“…Vitamin A is also an important factor that appears to be involved in the regulation of progenitor cells in the gastric glands. Recently, the expression of some retinoid and/or retinoic acid receptors was demonstrated in the gastric progenitor cells of various species including mice, rabbits, and humans 27 . Also, retinoic acid administration has been found to enhance both proliferation of gastric epithelial progenitors and differentiation of pit and zymogenic cell lineages in mice 28 .…”

Section: Regulation Of Stem Cell Dynamicsmentioning

confidence: 99%

Cellular Origin of Gastric Cancer

Karam

2008

Annals of the New York Academy of Sciences

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Gastric cancer is the second leading cause of cancer deaths worldwide. Although the link between Helicobacter pylori infection and gastric cancer is well established, little is known about the early development and detection of this malignant disease. Cancer is the disease of epithelia and recently, it has been suggested that some cancers originate in adult stem cells. Advances have been made in identifying the gastric epithelial stem cells and their immediate descendents, which act as progenitors giving rise to mucus-, acid-, pepsinogen-, and hormone-secreting cell lineages. Analyses of some genetically manipulated animal models in which the proliferation and differentiation program of the gastric stem/progenitor cells was altered by different approaches have provided some clues to the cellular origin of gastric cancer. Despite the challenges and the similarity between gastric epithelial progenitors and their differentiation program in mice and humans, it remains to be determined whether observations made in genetically engineered mice are also applicable to humans.

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Expression of retinoid receptors in multiple cell lineages in the gastric mucosae of mice and humans

Abstract: Retinoid receptors are expressed in multiple cell lineages of the mouse and human gastric epithelium and may, therefore, account for the possible effects of retinoids on gastric epithelial cell proliferation and differentiation.

Cited by 7 publications

References 27 publications

Retinoid Receptors in Gastric Cancer: Expression and Influence on Prognosis

Retinoid Receptors in Gastric Cancer: Expression and Influence on Prognosis

Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review

Cellular Origin of Gastric Cancer

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