Cellular Origin of Gastric Cancer

Abstract

Gastric cancer is the second leading cause of cancer deaths worldwide. Although the link between Helicobacter pylori infection and gastric cancer is well established, little is known about the early development and detection of this malignant disease. Cancer is the disease of epithelia and recently, it has been suggested that some cancers originate in adult stem cells. Advances have been made in identifying the gastric epithelial stem cells and their immediate descendents, which act as progenitors giving rise to mucus-, acid-, pepsinogen-, and hormone-secreting cell lineages. Analyses of some genetically manipulated animal models in which the proliferation and differentiation program of the gastric stem/progenitor cells was altered by different approaches have provided some clues to the cellular origin of gastric cancer. Despite the challenges and the similarity between gastric epithelial progenitors and their differentiation program in mice and humans, it remains to be determined whether observations made in genetically engineered mice are also applicable to humans.

Far Upstream Element-Binding Protein 1 (FUBP1) is Overexpressed in Human Gastric Cancer Tissue Compared to Non-Cancerous Tissue

“…Gastric cancer is a malignant neoplasm of the epithelia, and it was recently suggested that some cancers originate in adult stem cells [1]. Although the incidence of gastric cancer around the world has decreased, the number of new cases is increasing annually owing to the aging population; from a global perspective, it still ranks as the 4th most common cancer worldwide and the second most common cause of cancer-related death [2,3].…”

Simulation of Swanson's Literature-Based Discovery: Anandamide Treatment Inhibits Growth of Gastric Cancer Cells In Vitro and In Silico

“…Gastric cancer is a multifactorial disease, with numerous causative variables having been reported, including H. pylori , high-sodium diets, drinking, and smoking [16]. Previous studies in our laboratory have specialized in gastric cancer; therefore the objective of this study was to find new knowledge in the gastric cancer research field.…”

Upper Gastrointestinal Carcinogenesis: H. pylori and Stem Cell Cross-Talk

“…Advances have been made with respect to identifying the gastric epithelial stem cells and their immediate descendents, which act as progenitors giving rise to mucus-, acid-, pepsinogen-, and hormone-secreting cell lineages. Analyses of some genetically manipulated animal models in which the proliferation and differentiation program of the gastric stem cells was altered by different approaches have provided some clues to the cellular origin of gastric malignancy [21].…”