Simulation of Swanson's Literature-Based Discovery: Anandamide Treatment Inhibits Growth of Gastric Cancer Cells In Vitro and In Silico

Abstract

Swanson's literature-based discovery focus on resurrecting previously published but neglected knowledge. In this study, we propose a two-step model of the discovery process and generate a hypothesis between anandamide and gastric cancer. Further, the potential relationship was confirmed by follow-up experimentation. The anandamide treatment resulted in cell cycle redistribution of gastric cancer cells. Most importantly, the variation of cell cycle was mediated by some genes from the B-terms of the closed discovery, indicating the potential role of the B-terms. Swanson's literature-based discovery not only collates data for possible interactions, but also provides the potential to observe the larger background behind these direct links and is an invaluable discovery tool for investigators.

A systematic review on literature-based discovery workflow

“…Additionally, other data sources such as PubMed Central (PMC) Open Access (Ding et al, 2013), Science Direct (Vicente-Gomila, 2014), Web of Science (Sebastian, Siew & Orimaye, 2015), IEEE Xplore Digital Library (Qi & Ohsawa, 2016), Engineering Village (Kibwami & Tutesigensi, 2014), ProQuest (Kibwami & Tutesigensi, 2014), EBSCO Host (Kibwami & Tutesigensi, 2014), INSPEC (Ye, Leng & Guo, 2010) have also been employed by several other LBD approaches to retrieve the articles for analysis. (Dong et al, 2014), Gene Expression Omnibus (GEO) database (Hristovski et al, 2010), ArrayExpress (AE) database (Maver et al, 2013), Manually Annotated Target and Drug Online Resource (MATADOR) (Crichton et al, 2018), Biological General Repository for Interaction Datasets (BioGRID) (Crichton et al, 2018), PubTator (Crichton et al, 2018), Online Mendelian Inheritance in Man (OMIM) (Cohen et al, 2010) and TREC (Symonds, Bruza & Sitbon, 2014).…”

The Role of Endocannabinoid System in Menopause and Its Related-Diseases

“…Together with the reduction of estrogens, in postmenopausal women it has been also seen a decrease in AEA concentrations, similar to the luteal phase of premenopausal subjects [107]. Several authors reported the anti-cancer role of AEA, describing its capabilities to affect cell cycle distribution of gastric cancer cells [15,108,109] and also to reduce proliferation of neuroblastoma, prostate carcinoma and melanoma cells [110][111][112]. Cancer cells are more sensitive to endocannabinoids compared to healthy cells, since a most abundant presence of EC receptors on their surface [113].…”

Peer Review #1 of "A systematic review on literature-based discovery workflow (v0.1)"

“…Additionally, other data sources such as PubMed Central (PMC) Open Access (Ding et al, 2013), Science Direct (Vicente-Gomila, 2014), Web of Science (Sebastian et al, 2015), IEEE Xplore Digital Library (Qi and Ohsawa, 2016), Engineering Village (Kibwami and Tutesigensi, 2014), ProQuest (Kibwami and Tutesigensi, 2014), EBSCO Host (Kibwami and Tutesigensi, 2014), INSPEC (Ye et al, 2010) have also been employed by several other LBD approaches to retrieve the articles for analysis. (Dong et al, 2014), Gene Expression Omnibus (GEO) database (Hristovski et al, 2010), ArrayExpress (AE) database (Maver et al, 2013), Manually Annotated Target and Drug Online Resource (MATADOR) (Crichton et al, 2018), Biological General Repository for Interaction Datasets (BioGRID) (Crichton et al, 2018), PubTator (Crichton et al, 2018), Online Mendelian Inheritance in Man (OMIM) (Cohen et al, 2010) and TREC (Symonds et al, 2014).…”