Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer

Abstract

AIM:To investigate the prognostic significance of phosphatase regenerating liver 3 (PRL-3) protein expression in gastric cancer. METHODS:PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. Monoclonal antibody specifically against PRL-3, 3B6, was obtained with hybridoma technique. RESULTS:Positive PRL-3 expression was detected in 43.3% (127 of 293) of gastric cancer cases. High expression of PRL-3 was positively correlated with tumor size, depth of invasion, vascular/lymphatic invasion, lymph node metastasis, high TNM stage and tumor recurrence. Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression (28.3% vs 51.9%, P < 0.0001). Patients who received curative surgery, and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression (hazard ratio of 16.7 and 16.6, respectively; P < 0.0001 for both).Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients, particularly for survival in TNM stage Ⅲ patients.CONCLUSION: PRL-3 expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection.

Prognostic Significance of High Phosphatase of Regenerating Liver-3 Expression in Patients with Gastric Cancer Who Underwent Curative Gastrectomy

“…When univariate analysis was carried out for patients with moderate and high PRL-3 expression, histological type, pT stage, TNM stage, blood vessel invasion, and recurrence in patients with moderate PRL-3 expression, however, lymphatic vessel invasion and recurrence for patients with high PRL-3 expression were detected to be important prognostic factors. Our results are compatible with previous reports [19,20,[28][29][30].…”

“…Significant differences were detected in gender, histology, lymph node metastasis, and the presence of recurrence between PRL-3 expression groups. Thus, our results are compatible with the literature with respect to lymph node metastasis [19,20,22,[28][29][30] and gender [20] but differ from previous reports according to histological subtype [19,20,[28][29][30].…”

“…Moreover, Li et al [21] reported that PRL-3 expression was associated with peritoneal metastasis and poor prognosis in gastric cancer patients. Dai et al [28] showed that high PRL-3 expression was correlated with tumor size, depth of invasion, high TNM stage, and tumor recurrence, and patients with positive PRL-3 expression had a significant shorter OS and DFS. In light of all these findings, the authors concluded that PRL-3 expression was a novel prognostic factor for predicting the potential of recurrence and survival in patients with gastric cancer.…”

Genomic and genetic alterations influence the progression of gastric cancer

“…January 21, 2011|Volume 17|Issue 3| WJG|www.wjgnet.com Poor No [112][113][114] Tumor-associated proteases [115][116][117] proteinases) may influence the prognosis of patients with gastric cancer.…”

Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis

“…The expression of PRL-3 is frequently upregulated in human tumors, such as breast cancer (21), liver cancer (22), ovarian cancer (23), gastric cancer (24), and colorectal cancer (25). This expression is associated with cancer progression and poor survival.…”