Prognostic Significance of High Phosphatase of Regenerating Liver-3 Expression in Patients with Gastric Cancer Who Underwent Curative Gastrectomy

Bılıcı, Ahmet; Ustaalıoğlu, Bala Başak Öven; Yavuzer, Dilek; Şeker, Mesut; Mayadağlı, Alpaslan; Gümüş, Mahmut

doi:10.1007/s10620-012-2076-9

Cited by 7 publications

(11 citation statements)

References 34 publications

(75 reference statements)

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“…We revealed a correlation of positive PRL-3 and abnormal E-cadherin with mucinous type of gastric cancer. Similar observations have been reported by other authors, indicating a relationship between these proteins and signet ring cell-type carcinoma [21, 22]. It is likely that an abnormal expression of E-cadherin and an overexpression of PRL-3 are associated with the loss of cell junctions and loosening of cells in this histological type.…”

Section: Discussionsupporting

confidence: 90%

PRL-3 and E-cadherin show mutual interactions and participate in lymph node metastasis formation in gastric cancer

et al. 2014

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E-cadherin, a transmembrane adhesion molecule, and phosphatase of regenerating liver 3 (PRL-3) protein, a member of the family of tyrosine phosphatases, seem to be responsible for cancer cell migration. Therefore, the study objective was to determine a correlation between PRL-3 and E-cadherin, to assess their expression in neoplastic tissue and normal mucosa of the stomach, to analyze their effect on cancer advancement, and to evaluate their potential as prognostic markers in gastric cancer. The expressions of PRL-3 and E-cadherin were assessed immunohistochemically in 71 patients with gastric cancer. Positive expression of PRL-3 was observed in 42.2 % of gastric cancer cases, whereas E-cadherin expression was abnormal in 38 % of cases. The study revealed that the positive PRL-3 expression and abnormal E-cadherin expression were associated with mucinous gastric carcinoma and lymph node involvement. The former was also related to the infiltrating type of tumor and abnormal E-cadherin expression. The expression of PRL-3, but not of E-cadherin, was associated with shorter survival of patients. PRL-3 and E-cadherin exhibit interactions in gastric cancer and are involved in the formation of lymph node metastases. The PRL-3 protein can be an independent predictive factor of overall survival in gastric cancer patients.

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Section: Discussionsupporting

confidence: 90%

PRL-3 and E-cadherin show mutual interactions and participate in lymph node metastasis formation in gastric cancer

et al. 2014

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“…Up-regulated PRL-3 has been found in gastric carcinomas and was found to be significantly correlated to lymph node metastasis (25,26,27,28,29,30,31). Ovarian (32,33), liver (34,35), oral (36), cervical (37), esophageal (38), lung cancer (39,40), multiple myeloma (9,41), acute myeloid leukemia (AML) (42,43), and nasopharyngeal cancer (44) virtually all have been shown to exhibit high levels of PRL-3 expression.…”

Section: Role Of Prl In Cancermentioning

confidence: 99%

Phosphatase of regenerating liver: a novel target for cancer therapy

Campbell

Zhang

2014

Expert Opinion on Therapeutic Targets

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Importance in the Field Phosphatases of Regenerating Liver (PRLs) are novel oncogenes that interact with many, well-established cell signaling pathways that are misregulated in cancer and is known to drive cancer metastasis when overexpressed. Areas Covered in this Review This review will cover basic information of the discovery and characteristics of the PRL family. We will also report findings on the role of PRL in cancer, cell functions, and cell signaling. Furthermore, PRL’s suitability as a novel drug target will be discussed along with current methods being developed to facilitate PRL inhibition. Expert Opinion PRLs show great potential as novel drug targets for anti-cancer therapeutics. Studies indicate that PRL can perturb major cancer pathways such as Src/ERK1/2 and PTEN/PI3K/Akt. Upregulation of PRLs has also been shown to drive cancer metastasis. However, in order to fully realize its therapeutic potential, a deeper understanding of the function of PRL in normal tissue and in cancer must be obtained. Novel and integrated biochemical, chemical biological and genetic approaches will be needed to identify PRL substrate(s) and to provide proof-of-concept data on the druggability of the PRL phosphatases.

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“…The following articles were also excluded: one review-type article [15], and three duplicated publications [22]–[24] overlapping populations with other eligible studies [25], [26]. After selection, six studies published in English language were finally enrolled for analysis of the prognostic value of PRL-3 expression in the meta-analysis [25]–[30].The main characteristics of these six included studies are summarized in Table 1. Among these studies, a total of 1380 GC patients ranging from 71 to 639 patients per study were reported to have been evaluated for the effect of PRL-3 expression on OS.…”

Section: Resultsmentioning

confidence: 99%

“…The individual HRs of the included studies were calculated by one of the three methods reported in the “Data extraction” section. Three studies reported data from which the estimated HR can be directly retrieved [25], [26], [30]. For all other studies, HR had to be extrapolated from the survival curve [27]–[29].…”

Section: Resultsmentioning

confidence: 99%

“…For all other studies, HR had to be extrapolated from the survival curve [27]–[29]. Four out of six studies identified PRL-3 overexpression as an indicator of poor prognosis [25], [26], [28], [30], and all other studies showed no statistically significant effect of PRL-3 overexpression on survival period [27], [29]. According to the quality criteria, all studies were high quality.…”

Section: Resultsmentioning

confidence: 99%

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Poor Prognosis of Phosphatase of Regenerating Liver 3 Expression in Gastric Cancer: A Meta-Analysis

Luo

et al. 2013

PLoS ONE

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BackgroundOverexpression of phosphatase of regenerating liver 3 (PRL-3) has been implicated in gastric cancer (GC) metastasis. Epidemiological studies have evaluated the relationship between PRL-3 expression and prognosis in GC. However, results still remains controversial. In this study, a meta-analysis was performed to evaluate the association of PRL-3 expression with overall survival (OS) and clinicopathological characteristics.MethodsLiterature databases were searched to identify eligible studies dated until April 2013. Summary hazard ratios (HRs) or odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to estimate the association.ResultsA total of 1380 GC patients from six studies were included in the meta-analysis. Overall, the combined HR estimate for OS in a random-effect model was 1.89 (95% CI = 1.38–2.60; P<0.001). Results showed that PRL-3 overexpression was significantly associated with OS, indicating that it may be a biomarker for poor prognosis of GC. Both subgroup and sensitivity analyses further identified the prognostic role of PRL-3 expression in GC patients. Moreover, PRL-3 overexpression was significantly associated with tumor stage (OR = 2.25; 95% CI = 1.63–3.12; P<0.001), depth of invasion (OR = 2.03; 95% CI = 1.38–2.98; P<0.001), vascular invasion (OR = 2.52; 95% CI = 1.79–3.56; P<0.001), lymphatic invasion (OR = 3.74; 95% CI = 2.49–5.63; P<0.001), and lymph node metastasis (OR = 4.56; 95% CI = 2.37–8.76; P<0.001). However, when age, sex, tumor size, and tumor differentiation were considered, no obvious association was observed.ConclusionsThis meta-analysis reveals significant association of PRL-3 overexpression with OS and some clinicopathological features in GC. PRL-3 may be a predicative factor of poor prognosis and aggressive tumor behavior in GC patients.

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Prognostic Significance of High Phosphatase of Regenerating Liver-3 Expression in Patients with Gastric Cancer Who Underwent Curative Gastrectomy

Abstract: The potential value of PRL-3 expression as a useful molecular marker in gastric cancer progression should be evaluated comprehensively; it may predict recurrence and poor prognosis in patients with gastric cancer after curative resection.

Cited by 7 publications

References 34 publications

PRL-3 and E-cadherin show mutual interactions and participate in lymph node metastasis formation in gastric cancer

PRL-3 and E-cadherin show mutual interactions and participate in lymph node metastasis formation in gastric cancer

Phosphatase of regenerating liver: a novel target for cancer therapy

Poor Prognosis of Phosphatase of Regenerating Liver 3 Expression in Gastric Cancer: A Meta-Analysis

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