Expression of Perineuronal Nets, Parvalbumin and Protein Tyrosine Phosphatase σ in the Rat Visual Cortex During Development and After BFD

Liu, Hui; Xu, Haiwei; Yu, Tao; Yao, Junping; Zhao, Chenyang; Yin, Zheng

doi:10.3109/02713683.2013.803287

Cited by 22 publications

(21 citation statements)

References 34 publications

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“…The PNN+ cell density was similar in C57 and CBA mice. A strong association between PV+ and PNN+ cells in A1 was seen as reported in a number of other brain regions (Kosaka and Heizmann, 1989; Celio, 1993; Pantazopoulos et al, 2006; Liu et al, 2013; Yamada et al, 2015) is also present in A1. Approximately 35% of the PV+ cells in the C57 mouse A1 and 50% of PV+ cells in the CBA mouse A1 were also PNN+ (ratio of data in Figures 2B,C).…”

Section: Discussionsupporting

confidence: 69%

“…Although the expression of PNN and its association with specific cell types have been well characterized in rodent visual and somatosensory cortex (Pizzorusso et al, 2002; McRae et al, 2007; Liu et al, 2013; Takesian and Hensch, 2013) and subcortical auditory areas (Beebe et al, 2016), the expression patterns in A1 are only beginning to be described (reviewed in Sonntag et al, 2015). The relationship between PV and PNN expression in A1 has not been previously characterized.…”

Section: Discussionmentioning

confidence: 99%

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Age-Related Deterioration of Perineuronal Nets in the Primary Auditory Cortex of Mice

Brewton

Kokash

Jimenez

et al. 2016

Front. Aging Neurosci.

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Age-related changes in inhibitory neurotransmission in sensory cortex may underlie deficits in sensory function. Perineuronal nets (PNNs) are extracellular matrix components that ensheath some inhibitory neurons, particularly parvalbumin positive (PV+) interneurons. PNNs may protect PV+ cells from oxidative stress and help establish their rapid spiking properties. Although PNN expression has been well characterized during development, possible changes in aging sensory cortex have not been investigated. Here we tested the hypothesis that PNN+, PV+ and PV/PNN co-localized cell densities decline with age in the primary auditory cortex (A1). This hypothesis was tested using immunohistochemistry in two strains of mice (C57BL/6 and CBA/CaJ) with different susceptibility to age-related hearing loss and at three different age ranges (1–3, 6–8 and 14–24 months old). We report that PNN+ and PV/PNN co-localized cell densities decline significantly with age in A1 in both mouse strains. In the PNN+ cells that remain in the old group, the intensity of PNN staining is reduced in the C57 strain, but not the CBA strain. PV+ cell density also declines only in the C57, but not the CBA, mouse suggesting a potential exacerbation of age-effects by hearing loss in the PV/PNN system. Taken together, these data suggest that PNN deterioration may be a key component of altered inhibition in the aging sensory cortex, that may lead to altered synaptic function, susceptibility to oxidative stress and processing deficits.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Age-Related Deterioration of Perineuronal Nets in the Primary Auditory Cortex of Mice

Brewton

Kokash

Jimenez

et al. 2016

Front. Aging Neurosci.

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“…PNNs in the visual cortex of rodents appear over a time course that coincides with the closure of the ocular dominance critical period (Liu et al, 2013). Notably, any manipulation resulting in the disruption of PNN aggregation prevents the closure of the ocular dominance critical period (Carulli et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

Perineuronal Nets in the Adult Sensory Cortex Are Necessary for Fear Learning

Banerjee

Gutzeit

Baman

et al. 2017

Neuron

123

106

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Summary Lattice-like structures known as perineuronal nets (PNNs) are key components of the extracellular matrix (ECM). Once fully crystallized by adulthood, they are largely stable throughout life. Contrary to previous reports that PNNs inhibit processes involving plasticity, here we report that the dynamic regulation of PNN expression in the adult auditory cortex is vital for fear learning and consolidation in response to pure tones. Specifically, after first confirming the necessity of auditory cortical activity for fear learning and consolidation, we observed that mRNA levels of key proteoglycan components of PNNs were enhanced 4 hours after fear conditioning but were no longer different from the control groups 24 hours later. A similar pattern of regulation was observed in numbers of cells surrounded by PNNs and area occupied by them in the auditory cortex. Finally, the removal of auditory cortex PNNs resulted in a deficit in fear learning and consolidation.

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“…They can thus potentially act as a buffering system for physiologically relevant ions such as calcium, potassium, and sodium around highly active types of neurons (Bruckner et al, 1993; Bruckner et al, 1996b; Hartig et al, 1999), although direct evidence to this effect is still lacking. Even though PNNs have been shown to ensheath a variety of cells in the CNS, they are most commonly associated with the highly metabolically active fast-spiking parvalbumin interneurons (Hartig et al, 1999; Morris and Henderson, 2000; Ojima et al, 1995; Wegner et al, 2003)(Liu et al, 2013). These neurons express specific potassium channel subunits, such as Kv3.1b, which produce rapidly repolarizing action potentials (Lenz et al, 1994)(Du et al, 1996; Sekirnjak et al, 1997), thus contributing to the fast-spiking phenotype.…”

Section: Linking Pnns To Schizophrenia Pathophysiologymentioning

confidence: 99%

Perineuronal nets and schizophrenia: The importance of neuronal coatings

Bitanihirwe

Woo

2014

Neuroscience & Biobehavioral Reviews

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Schizophrenia is a complex brain disorder associated with deficits in synaptic connectivity. The insidious onset of this illness during late adolescence and early adulthood has been reported to be dependent on several key processes of brain development including synaptic refinement, myelination and the physiological maturation of inhibitory neural networks. Interestingly, these events coincide with the appearance of perineuronal nets (PNNs), reticular structures comprised of components of the extracellular matrix that coat a variety of cells in the mammalian brain. Until recently, the functions of the PNN had remained enigmatic, but are now considered to be important in development of the central nervous system, neuronal protection and synaptic plasticity, all elements which have been associated with schizophrenia. Here, we review the emerging evidence linking PNNs to schizophrenia. Future studies aimed at further elucidating the functions of PNNs will provide new insights into the pathophysiology of schizophrenia leading to the identification of novel therapeutic targets with the potential to restore normal synaptic integrity in the brain of patients afflicted by this illness.

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Expression of Perineuronal Nets, Parvalbumin and Protein Tyrosine Phosphatase σ in the Rat Visual Cortex During Development and After BFD

Abstract: The changes in the coexpression of PNNs, PV and PTPσ provide valuable insights into the connection between CSPGs and PV neurons.

Cited by 22 publications

References 34 publications

Age-Related Deterioration of Perineuronal Nets in the Primary Auditory Cortex of Mice

Age-Related Deterioration of Perineuronal Nets in the Primary Auditory Cortex of Mice

Perineuronal Nets in the Adult Sensory Cortex Are Necessary for Fear Learning

Perineuronal nets and schizophrenia: The importance of neuronal coatings

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