Expression of PCNA, p53, Bax, and Bcl-X in oral poorly differentiated and basaloid squamous cell carcinoma: Relationships with prognosis

Sampaio-Góes, Fernanda C. G.; Oliveira, Denise Tostes; Dorta, Regina Garcia; Nonogaki, Suely; Landman, Gilles; Nishimoto, Inês Nobuko; Kowalski, Luiz Paulo

doi:10.1002/hed.20258

Cited by 39 publications

(45 citation statements)

References 27 publications

(77 reference statements)

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“…Our results suggest that p53 have an important role in carcinogenesis either in SCC or in BSCC, and that there is no statistical significant difference in the expression of this protein in the two variants analyzed. This result is similar to other studies of oral cavity [18,19] and other lesions of the head and neck [26] and different from the results of Imamhasan et al [27] that found higher frequency of abnormal p53 expression in BSCC when compared to well-differentiated SCC; however, in their study, it was evaluated as esophagus squamous cell carcinoma. Corroborating our studies, recent data show the high prevalence of abnormal p53 expression in oral cavity SCC [16,28].…”

Section: Discussionsupporting

confidence: 75%

“…The prognostic value of p53 expression in SCC is still controversial; some believe that high expression is associated with poor survival [15], while others did not find this association [16,17]. Additionally, few studies investigated the p53 protein in BSCC exclusively of oral cavity [18,19]. These studies showed high prevalence of p53 abnormal expression, but did not find association with prognosis.…”

Section: Introductionmentioning

confidence: 99%

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p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma

et al. 2018

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Purpose The true aggressive behavior of oral cavity BSCC compared to SCC has been debated, and the study of disturbances in cell cycle proteins may help understand the biological behavior in both variants. The aim of this study was to investigate the p53 and p16 status in 32 SCC and 16 BSCC of oral cavity. Methods Immunohistochemistry was used to assess these proteins' status. The association between p53 and p16 with clinicopathological features and prognostic value were evaluated. Results A high prevalence of p53 disruption was observed in both variants (84.4% of 32-SCC and 81.2% of 16-BSCC; p = 0.78). The BSCC showed a higher prevalence of high p16 expression (86.7% of 15) when compared to SCC (61.3% of 31); however, this difference did not reach statistical significance (p = 0.08). In the SCC variant, cases with high p16 expression showed a lower overall survival. Protein p53 showed association with tobacco use, but with no other clinicopathological features. Conclusions Our results suggest that p53 and p16 cell cycle disruptions are common findings in oral cavity SCC, as well as in BSCC. A higher prevalence of p16 overexpression in oral BSCC cases may be related to carcinogenesis process.

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma

et al. 2018

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“…The numbers of patients with BSCC in these studies ranged from 4 to 49 (median, 10 patients). Eleven of these studies suggest that patients with BSCC have a worse prognosis, 1,2,10,11,13,15,18,20,[24][25][26] whereas the remaining studies either suggest that the behavior of BSCC is not different from SCC, 5,12,14,16,17,[21][22][23]27,28 or did not address the issue of comparative prognosis. 19,29 The common factor suggesting that BSCC has a worse prognosis in these studies has been the pro- pensity for BSCC to present in advanced stages and to have higher rates of hematogenous spread.…”

Section: Discussionmentioning

confidence: 99%

“…Highlighting the difficulties in selecting the best treatment for BSCC, biologic molecular patterns may provide some clues. Promising cell cycle markers, 14,29,33,34 apoptosis, differentiation, stem cells, and loss of heterozygosity 35 may provide directions for better treatment selection in the near future.…”

Section: Discussionmentioning

confidence: 99%

Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck

Thariat

Ahamad

El‐Naggar

et al. 2008

Cancer

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BACKGROUND.Basaloid squamous cell carcinoma (BSCC) is an uncommon, high‐grade variant of squamous cell carcinoma (SCC) of the head and neck. Its poorer prognosis compared with common SCC remains controversial. The authors investigated the outcomes of patients with BSCC who received radiotherapy and compared them with the outcomes of patients with SCC.METHODS.From 1994 to 2004, 1007 patients received radiotherapy for head and neck carcinoma with lymph node involvement. The histologic types consisted of 51 BSCC, 431 poorly differentiated SCC (PSCC), and 525 well or moderately differentiated SCC (WMSCC). A case–control analysis was performed with BSCC matched against both PSCC and WMSCC to compare disease‐control and survival rates.RESULTS.Patients with BSCC received treatment modalities similar to those received by patients with SCC: They received induction chemotherapy (12%) or concurrent chemotherapy (33%), and a median radiation dose of 70 Gray. Posttreatment viable tumor was present in 44%, 13%, and 28% of neck dissection specimens from patients with BSCC, PSCC, and WMSCC, respectively. The 5‐year disease‐free survival rates (63%, 77%, and 76%, respectively) and overall survival rates (85%, 70%, and 71%, respectively) demonstrated no statistically significant differences for BSCC, PSCC, or WMSCC, respectively.CONCLUSIONS.In this study, a poorer prognosis could not be demonstrated for irradiated patients with BSCC compared with either PSCC or WMSCC. All patients in this study had positive lymph node status, and the majority of patients (84%) had oropharyngeal cancer. The BSCC cohort did have a relatively high rate of viable tumor in their posttreatment neck dissections, and they had a relatively high rate of distant disease. On the basis of the high rate of lung metastases and the possibility of efficient salvage, the authors recommend obtaining a chest computed tomography scan during initial staging and follow‐up. Cancer 2008. © 2008 American Cancer Society.

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“…In agreement with earlier studies, the tumor cells in our case stained negative for P53, chromogranin, synaptophysin while positive for CK AE1/AE3 and EMA. The aggressive natural behavior of BSCC has been generally related to early recurrence, lymph node involvement and also distant metastasis to the liver and lung (18). Lymphatic involvement was not observed in our patient.…”

Section: Discussionmentioning

confidence: 46%

Non-Metastatic Basaloid Squamous Cell Carcinoma of the Uterine Cervix in a Woman with History of Subtotal Hysterectomy

et al. 2017

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Introduction: Basaloid squamous cell carcinoma (BSCC) of the cervix is an uncommon tumor in female genital tract. The aggressive clinical behavior makes this entity distinguished from other SCC subtypes. Case Presentation: We described a case of basaloid squamous cell carcinoma in uterine cervix in a 62-year old woman with previous subtotal hysterectomy. Clinical and radiologic examination suggested a 3 cm mass in cervical stump involving left parametrium. She underwent trachelectomy and lymph node dissection followed by adjuvant radiochemotherapy. The light microscopy and immunohistochemistry warranted the basaloid SCC diagnosis that was suspected in pre-operational biopsy. The small, round to ovalshaped cells with scant cytoplasm and hyperchromatic nuclei were positive for cytokeratin AE1/AE3 (CK AE1/AE3) and negative for p63, C-KIT, chromogranin and synaptophysin. Conclusions: Although this tumor has an aggressive behavior, this is not enough to substantiate that BSCC has a poorer medical outcome as compared to conventional SCC of the cervix.

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Expression of PCNA, p53, Bax, and Bcl-X in oral poorly differentiated and basaloid squamous cell carcinoma: Relationships with prognosis

Abstract: These results suggest that the clinical and biologic course of BSCC is similar to PDSCC in the oral cavity when clinical stage and site are matched.

Cited by 39 publications

References 27 publications

p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma

p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma

Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck

Non-Metastatic Basaloid Squamous Cell Carcinoma of the Uterine Cervix in a Woman with History of Subtotal Hysterectomy

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