Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors

Shoshan, Yigal; Nishiyama, Akiko; Chang, Ansi; Mörk, Sverre; Barnett, Gene H.; Cowell, John K.; Trapp, Bruce D.; Staugaitis, Susan M.

doi:10.1073/pnas.96.18.10361

Cited by 170 publications

(130 citation statements)

References 39 publications

(40 reference statements)

Supporting

Mentioning

117

Contrasting

Order By: Relevance

“…Pilocytic astrocytomas and a subset of glioblastomas are known to share some markers with oligodendrocyte progenitors such as NG2, PEN5, platelet-derived growth factor receptor ␣ (PDGFR␣). 34,35 Therefore, comparative study of Olig1/2 with these markers on gliomas is very interesting, and remains to be elucidated. Recently, a new concept, glioblastoma with oligodendroglial components, has been proposed based on accumulated evidence that a subset of glioblastoma includes areas with oligodendroglial features, or a subset of oligodendroglioma acquires the morphological features of glioblastoma during malignant progression.…”

Section: Discussionmentioning

confidence: 99%

Anti-Human Olig2 Antibody as a Useful Immunohistochemical Marker of Normal Oligodendrocytes and Gliomas

Yokoo¹,

Nobusawa²,

Takebayashi³

et al. 2004

The American Journal of Pathology

130

102

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Human Olig2 Antibody as a Useful Immunohistochemical Marker of Normal Oligodendrocytes and Gliomas

Yokoo¹,

Nobusawa²,

Takebayashi³

et al. 2004

The American Journal of Pathology

130

102

View full text Add to dashboard Cite

show abstract

“…2a, available at www.jneurosci.org as supplemental material), indicating a subspecification of these cells. Approximately 35% of nestin-GFP-positive cells, expressed the chondroitin sulfate proteoglycan NG-2, a marker for glial precursors and neoplastic cells (Shoshan et al, 1999). Interestingly, NG-2 was colocalized with both nestin-GFP-positive cells and the G261 tumor cells (Fig.…”

Section: Characterization Of Neural Precursors Surrounding Glioblastomasmentioning

confidence: 99%

Glioblastoma-Induced Attraction of Endogenous Neural Precursor Cells Is Associated with Improved Survival

Glaß

Synowitz²,

Kronenberg³

et al. 2005

J. Neurosci.

192

172

View full text Add to dashboard Cite

Neural precursor cells contribute to adult neurogenesis and to limited attempts of brain repair after injury. Here we report that in a murine experimental glioblastoma model, endogenous neural precursors migrate from the subventricular zone toward the tumor and surround it. The association of endogenous precursors with syngenic tumor grafts was observed, after injecting red fluorescent proteinlabeled G261 cells into the caudate-putamen of transgenic mice, which express green fluorescent protein under a promoter for nestin (nestin-GFP). Fourteen days after inoculation, the nestin-GFP cells surrounded the tumors in several cell layers and expressed markers of early noncommitted and committed precursors. Nestin-GFP cells were further identified by a characteristic membrane current pattern as recorded in acute brain slices. 5-Bromo-2-deoxyuridine labeling and dye tracing experiments revealed that the tumor-associated precursors originated from the subventricular zone. Moreover, in cultured explants from the subventricular zone, the neural precursors showed extensive tropism for glioblastomas. Tumor-induced endogenous precursor cell accumulation decreased with age of the recipient; this correlated with increased tumor size and shorter survival times in aged mice. Coinjection of glioblastoma cells with neural precursors improved the survival time of old mice to a level similar to that in young mice. Coculture experiments showed that neural precursors suppressed the rapid increase in tumor cell number, which is characteristic of glioblastoma, and induced glioblastoma cell apoptosis. Our results indicate that tumor cells attract endogenous precursor cells; the presence of precursor cells is antitumorigenic; and this cellular interaction decreases with aging.

show abstract

“…These markers include NG2, PDGFRα and Olig-2. [5][6][7][72][73][74] Oligodendrocyte progenitors remain widespread in the adult brain 42,56,75,76 and represent the most abundant population of cycling cells in the adult central nervous system, 4,53,55,77 thus providing a likely pool of cells in which accumulating mutations can lead to gliomagenesis. The sensitivity of these progenitors to mitogenic stimulation may play a role in their susceptibility to transformation.…”

Section: Ng2 Expression In Gliomasmentioning

confidence: 99%

A role for the NG2 proteoglycan in glioma progression

Stallcup

Huang

2008

Cell Adhesion & Migration

121

138

View full text Add to dashboard Cite

Many human gliomas carry markers characteristic of oligodendrocyte progenitor cells (such as Olig-2, PDGF alpha receptor and NG2 proteoglycan), suggesting these progenitors as the cells of origin for glioma initiation. This review considers the potential roles of the NG2 proteoglycan in glioma progression. NG2 is expressed not only by glioma cells and by oligodendrocyte progenitors, but also by pericytes associated with the tumor microvasculature. The proteoglycan may therefore promote tumor vascularization and recruitment of normal progenitors to the tumor mass, in addition to mediating expansion of the transformed cell population. Along with potentiating growth factor signaling and serving as a cell surface receptor for extracellular matrix components, NG2 also has the ability to mediate activation of b-1 integrins. These molecular interactions allow the proteoglycan to contribute to critical processes such as cell proliferation, cell motility and cell survival.

show abstract

Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors

Cited by 170 publications

References 39 publications

Anti-Human Olig2 Antibody as a Useful Immunohistochemical Marker of Normal Oligodendrocytes and Gliomas

Anti-Human Olig2 Antibody as a Useful Immunohistochemical Marker of Normal Oligodendrocytes and Gliomas

Glioblastoma-Induced Attraction of Endogenous Neural Precursor Cells Is Associated with Improved Survival

A role for the NG2 proteoglycan in glioma progression

Contact Info

Product

Resources

About