Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen

Satoh, Takashi; Oikawa, Hiroki; Yashima-Abo, Akiko; Nishiya, Masao; Masuda, Tomoyuki

doi:10.3960/jslrt.19032

Cited by 3 publications

(5 citation statements)

References 29 publications

(50 reference statements)

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“…Steiniger reported the existence of three types of stromal cells within the WP, as well as other stromal cells outside the circumferential reticulum 56 . Mucosal vascular address in cell adhesion molecule 1 (MAdCAM‐1), which is a ligand for the homing receptors of lymphocytes, 57 is expressed on the reticulum cells of the PALS and outer layer of the MZ in the human spleen 58,59 . These heterogenous reticular tissues create unique microenvironments for lymphocytes and other free cells and for splenic compartments 58 .…”

Section: The Spleenmentioning

confidence: 99%

“…Abundant arterial blood flows into the reticular meshwork of the outer layer of the MZ from open‐ended arterial terminals of the follicular and penicillar arterioles 20 . (Figure 3) MAdCAM‐1 expresses on smooth muscle α‐actin‐positive reticular cells, which exist at the inner border of the MZ outer layer 56,58,59 …”

Section: The Spleenmentioning

confidence: 99%

“…56 Mucosal vascular address in cell adhesion molecule 1 (MAdCAM-1), which is a ligand for the homing receptors of lymphocytes, 57 is expressed on the reticulum cells of the PALS and outer layer of the MZ in the human spleen. 58,59 These heterogenous reticular tissues create unique microenvironments for lymphocytes and other free cells and for splenic compartments. 58 The high endothelial venule (HEV), from which lymphocytes enter from the blood into the lymphatic tissue, does not exist in the WP.…”

Section: The Spleenmentioning

confidence: 99%

“…20 (Figure 3) MAdCAM-1 expresses on smooth muscle αactin-positive reticular cells, which exist at the inner border of the MZ outer layer. 56,58,59 3.4.1 | Nomenclature of the human splenic marginal zone…”

Section: Marginal Zonementioning

confidence: 99%

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Blood defense system – Proposal for a new concept of an immune system against blood borne pathogens comprising the liver, spleen and bone marrow

Kashimura

2024

Scand J Immunol

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Blood‐borne pathogen (BBP) infections can rapidly progress to life‐threatening sepsis and must therefore be promptly eliminated by the host's immune system. Intravascular macrophages of the liver sinusoid, splenic marginal zone and red pulp and perisinusoidal macrophage protrusions in the bone marrow (BM) directly phagocytose BBPs in the blood as an innate immune response. The liver, spleen and BM thereby work together as the blood defence system (BDS) in response to BBPs by exerting their different immunological roles. The liver removes the vast majority of these invading organisms via innate immunity, but their complete elimination is not possible without the actions of antibodies. Splenic marginal zone B cells promptly produce IgM and IgG antibodies against BBPs. The splenic marginal zone transports antigenic information from the innate to the adaptive immune systems. The white pulp of the spleen functions as adaptive immune tissue and produces specific and high‐affinity antibodies with an immune memory against BBPs. The BM works to maintain immune memory by supporting the survival of memory B cells, memory T cells and long‐lived plasma cells (LLPCs), all of which have dedicated niches. Furthermore, BM perisinusoidal naïve follicular B cells promptly produce IgM antibodies against BBPs in the BM sinusoid and the IgG memory B cells residing in the BM rapidly transform to plasma cells which produce high‐affinity IgG antibodies upon reinfection. This review describes the complete immune defence characteristics of the BDS against BBPs through the collaboration of the liver, spleen and BM with combined different immunological roles.

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Section: The Spleenmentioning

confidence: 99%

Section: The Spleenmentioning

confidence: 99%

Section: The Spleenmentioning

confidence: 99%

Section: Marginal Zonementioning

confidence: 99%

See 2 more Smart Citations

Blood defense system – Proposal for a new concept of an immune system against blood borne pathogens comprising the liver, spleen and bone marrow

Kashimura

2024

Scand J Immunol

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show abstract

“…3 On immunostaining, the cells bordering the white pulp show alpha-smooth muscle actin and expression of mucosal addressin cell adhesion molecule-1, suggesting its function in lymphocyte homing and segregation of the lymph follicle from the blood. 4 , 6 …”

Section: To the Editormentioning

confidence: 99%

The perifollicular zone of the spleen as a distributor and filter of blood components

Sasou

2021

J Clin Exp Hematopathol

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Asplenia and spleen hypofunction

Lenti

Luu

Carsetti

et al. 2022

Nat Rev Dis Primers

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Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen

Cited by 3 publications

References 29 publications

Blood defense system – Proposal for a new concept of an immune system against blood borne pathogens comprising the liver, spleen and bone marrow

Blood defense system – Proposal for a new concept of an immune system against blood borne pathogens comprising the liver, spleen and bone marrow

The perifollicular zone of the spleen as a distributor and filter of blood components

Asplenia and spleen hypofunction

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