2009
DOI: 10.1590/s1415-47572009005000041
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Abstract: The Dumbo rat possesses some characteristics that evoke several human syndromes, such as Treacher-Collins: shortness of the maxillary, zygomatic and mandibular bones, and low position of the ears. Knowing that many homeobox genes are candidates in craniofacial development, we investigated the involvement of the Msx1 and Dlx1 genes in the Dumbo phenotype with the aim of understanding their possible role in abnormal craniofacial morphogenesis and examining the possibility of using Dumbo rat as an experimental mo… Show more

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Cited by 3 publications
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“…Prior to the mapping of the rat dmbo mutation to the Hmx1 locus, dysregulation of the homeobox genes Msx1 and Dlx1 was proposed as a causative mechanism for the rat dumbo phenotype ( Katerji et al, 2009 ). Loss-of-function mutations in Msx1/2 and Dlx1/2 result in much more extensive defects in craniofacial development than the phenotypes observed in the dumbo rat and mouse ( Ishii et al, 2005 ; Qiu et al, 1997 ; Qiu et al, 1995 ).…”
Section: Discussionmentioning
confidence: 99%
“…Prior to the mapping of the rat dmbo mutation to the Hmx1 locus, dysregulation of the homeobox genes Msx1 and Dlx1 was proposed as a causative mechanism for the rat dumbo phenotype ( Katerji et al, 2009 ). Loss-of-function mutations in Msx1/2 and Dlx1/2 result in much more extensive defects in craniofacial development than the phenotypes observed in the dumbo rat and mouse ( Ishii et al, 2005 ; Qiu et al, 1997 ; Qiu et al, 1995 ).…”
Section: Discussionmentioning
confidence: 99%