EXPRESSION OF mRNAS FOR CHEMOKINES AND CHEMOKINE RECEPTORS IN THE SKIN FROM PATIENTS WITH PSORIASIS

Бельтюкова, А. С.; Сысоев, К. А.; Ильина, Т. Н.; Шемеровская, Т Г; Хобейш, М. М.; Monakhov, K N; Тотолян, Арег А.

doi:10.15789/1563-0625-2008-4-5-337-346

Cited by 3 publications

(3 citation statements)

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“…Изобретение цитоиммунограммы кожи открывает для практической дерматологии и косметологии путь к новому пониманию процессов, проходящих в коже человека, дает возможность количественно оценить показатели состояния кожи не только в рамках отдельного человека, но и в рамках популяции, не только в условиях нормы, но, что немаловажно, в условиях патологии. Тем более что в роли системы хемокинов в коже, например в патогенезе псориаза, уже нет никаких сомнений [2].…”

Section: Discussionunclassified

“…При этом на протяжении всего периода изучения кожи было и остается актуальным изучение фенотипа клеток ее составляющих. Актуальным остается изучение роли хемокинов и соответствующих им хемокиновых рецепторов в патогенезе хронических заболеваний кожи [2]. Но сложность исследований обусловлена прочными десмосомальными связями клеток, препятствующими их разделению и изучению в живом виде и по отдельности.…”

Section: Introductionunclassified

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Cytoimmunogram of the Skin: A New Method for Objective Evaluation of the Skin Cell Subpopulation Profile

Goltsov¹,

Goltsova²,

Sukhovey³

et al. 2018

Med. immunol.

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Гольцов С.В. и др. Medical Immunology (Russia)/Meditsinskaya Immunologiya Медицинская Иммунология клеток, оценить их функцию и степень их реагирования в ответ на какие-либо воздействия внешней и внутренней среды. Широкомасштабное применение цитоиммунограммы в перспективе позволит создать половозрастной регистр состояния кожи в норме и патологии, что позволит определять степень реагирования кожи на воздействия среды, измерять активность клеточных субпопуляций нативной кожи в условиях нормы и патологии, использовать критерий возрастных изменений кожи, объективно оценивать динамику заболевания кожи, индивидуально подбирать лекарственный препарат и контролировать эффективность применяемых наружных лекарственных средств.

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Section: Discussionunclassified

Section: Introductionunclassified

Cytoimmunogram of the Skin: A New Method for Objective Evaluation of the Skin Cell Subpopulation Profile

Goltsov¹,

Goltsova²,

Sukhovey³

et al. 2018

Med. immunol.

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“…CCL20 является единственным CCR6-запускающим хемокином и не способен вызывать биологический ответ через другие известные рецепторы хемокинов, однако важно отметить, что β-дефензин, как и другие антибактериальные пептиды, усиленно экспрессирующиеся при псориазе, может являться лигандом для CCR6, приводя к рекрутированию дополнительных клеток CCR6 + Th17. Гиперэкспрессия хемокинов и их рецепторов показана не только в псориатическом очаге, но и в участках визуально здоровой кожи, что указывает на важную роль хемокинов в развитии псориатического воспаления и системности процесса [1].…”

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Mechanisms of innate immunity in pathogenesis of psoriasis: approaches to targeted therapy

2020

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Psoriasis is a chronic auto-inflammatory, genetically determined dermatosis, being multifactorial by origin, characterized by hyperproliferation of epidermis, affected keratinocyte differentiation and inflammatory reaction in dermis. The disease is characterized by a tendency to spread over the area of lesion, and involvement of articular tissue in the pathological process, which significantly affects the living standards of patients and causes their disability. There are many provoking factors that contribute to occurrence of psoriasis, or progression of existing psoriatic process in individuals with a genetic predisposition. These factors include adverse climatic conditions, skin trauma, exposure to ultraviolet light, burns, infections, etc.This review describes the role of innate immunity in pathogenesis of psoriasis, and describes in detail the mechanisms involved into induction of inflammation of PAMPs and DAMPs. In psoriasis, positively charged catelicidin is considered one of the most important DAMPs, which can form a complex with negatively charged cell polyanions-LL-37/auto-RNA and LL-37/auto-DNA. The interaction of PAMP/DAMP ligands with specific PRR receptors leads to signal activation of effector components of immune system, i.e., assembly of inflammasome complex, caspase activation, synthesis of inflammatory cytokines and processing of their immature forms. The review focuses on the role of TLRs under the conditions of physiological norm, which recognize danger signals and provide protection from pathogens and their timely elimination, and in development of pathological process. Activation of TLRs induces the production of pro-inflammatory cytokines, interferons and antimicrobial peptides, chemokines that support the development of psoriatic inflammation.In addition to TLRs, the mechanisms of involvement of inflammasomes in the development of psoriasis, which provides processing of mature forms of IL-1β and IL-18, are described in detail. Mature forms of these cytokines mediate the development of inflammation in psoriatic focus. In addition, processing of these cytokines by caspases using the positive feedback mechanism provides an additional signal to activate transcriptional activity of their genes and contributes to perpetuated inflammation.The review presents data confirming participation of inflammasomes in the pathogenesis of psoriasis. Much attention is paid to description of pharmacological inhibitors of inflammasomes, which in the future may be the drugs of choice for treatment of inflammatory diseases. The study of molecular mechanisms of the innate immune system will reveal new approaches to prognosis and development of targeted therapy for psoriasis.

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Main level of cytokines in patients with psoriasis

Beltyukova¹,

Хобейш

Sokolovsky

2015

Vestnik dermatologii i venerologii

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The aim of the study was to determine the level of cytokines in the serum of patients with psoriatic arthritis (PsA) and psoriasis vulgaris (Ps) and to identify key immune markers associated with clinical manifestations of psoriasis. Materials and methods. The study involved 52 patients with psoriatic arthritis (PsA) and 20 patients with psoriasis vulgaris (PS) by multiplex analysis of proteins using Bio-Plex device and commercial test kits 23-Plex and 27-Plex, 8-Plex. Assessment of the severity and prevalence of psoriatic skin lesions in patients was conducted by index PASI (Psoriasis Area and Severity Index). Indicators of acute-phase activity (ESR, CRP), CEC were defined in all patients. the comparison group consisted of patients with a diagnosis of patchy scleroderma (10 patients) and patients with atopic dermatitis (10 patients). 13 healthy individuals were examined as a control group. Main results. Significant elevation of cytokines: IL-2, IL-6, GM-CSF, IFN-y and TNF-a was found in the serum of patients with PS compared with the group of apparently healthy individuals, and GM-CSF, IFN-y compared with patients with atopic dermatitis. It was determined that the detected levels of Il-В in serum has a direct correlation with the prevalence and severity of PS. Inverse correlation between ESR and the level of IL-8, GM-CSF and the CEC, IFN-y and the CEC and the direct correlation between the level of TNF-a and CRP in serum were shown. Conclusion. The obtained data indicate shifts in the system of pro-inflammatory and anti-inflammatory cytokines in psoriasis, which can be considered as a manifestation of endogenous homeostatic mechanisms designed to limit the intensity of the inflammatory process. Immune markers associated with clinical manifestations of psoriasis, in particular, the prevalence and severity of PS (index PASI), indicators of acute-phase activity (ESR, CRP), were identified.

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EXPRESSION OF mRNAS FOR CHEMOKINES AND CHEMOKINE RECEPTORS IN THE SKIN FROM PATIENTS WITH PSORIASIS

Cited by 3 publications

References 0 publications

Cytoimmunogram of the Skin: A New Method for Objective Evaluation of the Skin Cell Subpopulation Profile

Cytoimmunogram of the Skin: A New Method for Objective Evaluation of the Skin Cell Subpopulation Profile

Mechanisms of innate immunity in pathogenesis of psoriasis: approaches to targeted therapy

Main level of cytokines in patients with psoriasis

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