Expression of miR-31 in saliva-liquid biopsy in patients with oral squamous cell carcinoma

Kumari, Parma; Syed, Sadiqa; Wahid, Mohsin; Qureshi, Muhammad Asif; Kumar, Rajesh

doi:10.1016/j.jtumed.2021.03.007

Cited by 10 publications

(11 citation statements)

References 29 publications

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“…A recent study on 40 Asian cohorts also proved that the salivary miR-31 levels were significantly increased in preoperative patients than in postoperative OSCC patients [59]. Furthermore, according to Siow et al, miR-31 levels were significantly higher in early-stage tumors with no metastatic nodes and those from buccal mucosa with microarray profiling and real-time PCR.…”

Section: Mir-31 As a Diagnostic/prognostic Biomarkermentioning

confidence: 88%

A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma

Kavitha

Jayachandran

Aishwarya³

et al. 2022

Egypt J Med Hum Genet

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Background Micro-RNAs (miRNAs) have been reported as an emerging biomarker in many cancer types. They are used as diagnostic and prognostic biomarkers and could be considered therapeutic targets in treating the same. Main body Studies have proven that miRNAs play an essential role in molecular cancer pathophysiology, including oral squamous cell carcinoma. Distinct expression profiles of different miRNAs have been demonstrated in oral squamous cell carcinoma. Among the miRNAs, the miR-31 has strong potential as a unique biomarker in head and neck squamous cell carcinoma, and the increased expression was correlated to a poor clinical outcome with a likely contribution to oral carcinogenesis. Short conclusion The recent research on different aspects of miR-31 as a biomarker and also its potential application in the development of therapy for oral squamous cell carcinoma has been focused in this review. Graphical abstract

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Section: Mir-31 As a Diagnostic/prognostic Biomarkermentioning

confidence: 88%

A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma

Kavitha

Jayachandran

Aishwarya³

et al. 2022

Egypt J Med Hum Genet

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“…In recent years, saliva-based liquid biopsy for cancer has received much attention [127][128][129][130][131][132]. Analyzing components of saliva can reflect genomic and epigenomic alterations involved in physiological and pathological processes, and thus reflecting a person's physical conditions [133][134][135].…”

Section: Saliva Dna Methylation-based Liquid Biopsy For Lcmentioning

confidence: 99%

Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer

Liu

et al. 2022

Clin Epigenet

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Lung cancer (LC) is the main cause of cancer-related mortality. Most LC patients are diagnosed in an advanced stage when the symptoms are obvious, and the prognosis is quite poor. Although low-dose computed tomography (LDCT) is a routine clinical examination for early detection of LC, the false-positive rate is over 90%. As one of the intensely studied epigenetic modifications, DNA methylation plays a key role in various diseases, including cancer and other diseases. Hypermethylation in tumor suppressor genes or hypomethylation in oncogenes is an important event in tumorigenesis. Remarkably, DNA methylation usually occurs in the very early stage of malignant tumors. Thus, DNA methylation analysis may provide some useful information about the early detection of LC. In recent years, liquid biopsy has developed rapidly. Liquid biopsy can detect and monitor both primary and metastatic malignant tumors and can reflect tumor heterogeneity. Moreover, it is a minimally invasive procedure, and it causes less pain for patients. This review summarized various liquid biopsies based on DNA methylation for LC. At first, we briefly discussed some emerging technologies for DNA methylation analysis. Subsequently, we outlined cell-free DNA (cfDNA), sputum, bronchoalveolar lavage fluid, bronchial aspirates, and bronchial washings DNA methylation-based liquid biopsy for the early detection of LC. Finally, the prognostic value of DNA methylation in cfDNA and sputum and the diagnostic value of other DNA methylation-based liquid biopsies for LC were also analyzed.

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“… Wang et al [ 43 ] OSCC tissues and cells Up; Oncogenic Apoptosis, cisplatin sensitivity KANK1 Long non-coding RNA CASC2- miR-31-5p/KANK1 axis ↑ miR-31-5p was upregulated in cisplatin-resistant OSCC tissues and cells, KANK1 acted as a target for miR-31-5p; CASC2 modulated KANK1 expression via sponging miR-31-5p. Kumari et al [ 44 ] Patients saliva Up; Oncogenic Clinical study Clinical study Clinical study The salivary miR-31 level was significantly higher in the preoperative patients than that of postoperative ( P < 0.001). miR-31 might be a potential non-invasive marker to monitor surgery outcomes during postoperative follow-up in patients with OSCC.…”

Section: Introductionmentioning

confidence: 99%

“…Besides, Liu et al demonstrated that miR-31 was more abundant in saliva than in plasma. Kumari et al [ 44 ]revealed that the salivary miR-31 level was significantly higher in the preoperative patients than that of postoperative ( P < 0.001), suggesting miR-31 might be a potential non-invasive marker to monitor surgery outcomes during postoperative follow-up in patients with OSCC. Higher levels of miR-31 level have frequently been found in OSCC patients than cancer-free individuals, while miR-31 expression in metastatic- and non-metastatic OSCC is rarely reported.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-31: a pivotal oncogenic factor in oral squamous cell carcinoma

Lin

Wu²,

Ying

et al. 2022

Cell Death Discov.

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Oral squamous cell carcinoma (OSCC) continuously constitutes a major challenge for treatment and prognosis due to approximately half of treated OSCC patients dying from locoregional recurrences and distant metastases. MicroRNA-31 (miR-31), an early mammalian miRNA identified, has been gaining importance in the field of OSCC research in recent years. This comprehensive review was conducted for the first time to summarize the current evidence on the association between miR-31 and OSCC. The vast majority of relevant studies (20/21, 95%) demonstrated that miR-31 was an oncogenic factor in the tumorigenesis and progression of OSCC. miR-31 expression is significantly upregulated in plasma, saliva, and tumor tissue of OSCC. miR-31 played an essential role in OSCC development by constituting a complex network with its targeted genes (e.g. RhoA, FIH, ACOX1, VEGF, SIRT3, LATS2, KANK1, and NUMB) and the signaling cascades (e.g. EGF-AKT signaling axis, ERK-MMP9 cascade, Hippo pathway, Wnt signaling, and MCT1/MCT4 regulatory cascade). This review highlights that miR-31 might function as a potential diagnostic, prognostic, and predictive biomarker for OSCC. Further studies are still warranted to better illuminate the clinicopathological features and the molecular mechanisms of miR-31-mediated OSCC development.

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Expression of miR-31 in saliva-liquid biopsy in patients with oral squamous cell carcinoma

Cited by 10 publications

References 29 publications

A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma

A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma

Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer

MicroRNA-31: a pivotal oncogenic factor in oral squamous cell carcinoma

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