Expression of major histocompatibility complex antigens on inflammatory peripheral nerve lesions

Yu, Leonard T.; Rostami, Abdolmohammad; Silvers, Wilys K.; LaRossa, Don; Hickey, William F.

doi:10.1016/0165-5728(90)90095-5

Cited by 39 publications

(20 citation statements)

References 35 publications

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“…Class I expression at the lower level has been documented on endothelial/or perivascular cells of normal Lewis rats (Yu et al, 1990). Thus the MHC class I 1 cells that we observed could be endothelial/perivascular cells.…”

Section: Expression Of Mhc Class I Antigens In Normal Mouse Nervous Smentioning

confidence: 65%

Expression of major histocompatibility complex class I antigens in the demyelinating twitcher CNS and PNS

et al. 1997

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Section: Expression Of Mhc Class I Antigens In Normal Mouse Nervous Smentioning

confidence: 65%

Expression of major histocompatibility complex class I antigens in the demyelinating twitcher CNS and PNS

et al. 1997

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“…The Schwann cells found in nerve allografts contribute to peripheral nerve allograft immunogenicity through the expression of MHC class-I and -II antigen. 38 These allogeneic intragraft Schwann cells elicit a vigorous immune response that ultimately results in rapid graft destruction in the absence of immunomodulatory therapy. Even in cyclosporine-immunosuppressed animals, endogenous host Schwann cells were found to migrate into the transplanted nerve allograft and eventually replace these allogeneic Schwann cells.…”

Section: Discussionmentioning

confidence: 99%

Effects of Schwann cells and donor antigen on long-nerve allograft regeneration

et al. 2005

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Nerve allotransplantation has been used successfully in human subjects to restore function after traumatic nerve injury and avoid subsequent limb amputation. However, due to the morbidity associated with nonspecific immunosuppression, this reconstructive approach has been limited to patients with particularly severe nerve injuries. It would be desirable to broaden the indications for such procedures through development of less toxic antirejection therapies. A miniature swine model of nerve transplantation was used to investigate the effects of preoperative ultraviolet-B (UV-B)-irradiated donor alloantigen portal venous infusion and injection of cultured major histocompatibility complex (MHC)-matched Schwann cells into the nerve graft. The transplanted ulnar nerves were harvested at 20 weeks. Histomorphometry showed marked enhancement in nerve regeneration through allografts injected with Schwann cells. Serial mixed lymphocyte assays demonstrated suppression of the recipient immune response to the donor antigen after pretreatment, but no additional neuroregenerative effect of donor alloantigen pretreatment.

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“…2 The addition of autologous cells would not, however, diminish the number of donor Schwann cells in the graft expressing MHC-I and MHC-II antigens. 1,3 As such, the immune response to the nerve allograft seeded with autologous Schwann cells should not be significantly altered, and a full dose of immunosuppression would be required to prevent rejection of the antigenic load. Clinically, we have had a single case of nerve allograft rejection, 59 which prompted us to study the abilities of CsA, 60 and the immunosuppressant FK506 58 to treat peripheral nerve rejection.…”

Section: Discussionmentioning

confidence: 99%

Safe injection of cultured Schwann cells into peripheral nerve allografts

et al. 2000

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The effects of cultured host Schwann cells on axonal regeneration in peripheral nerve allografts were studied. Fischer rats served as recipient animals and Buffalo rats provided nerve allografts. Animals were randomized into 9 groups. Rats receiving tibial nerve isografts were left untreated (group I), or injected with isogeneic Fischer Schwann cells (group II) or placebo suspension (group III). Allografts obtained from Buffalo rats were left untreated (group IV), or received isogeneic Fischer Schwann cells (group V), 2 mg/kg Cyclosporin A and Fischer Schwann cells (group VI), 5 mg/kg Cyclosporin A (group VII), or 5 mg/kg Cyclosporin A with Schwann cells (group VIII). No Schwann cell tumors were identified 4 or 8 weeks postoperatively. Group IX animals, harvested 3 days postoperatively, demonstrated no evidence of injection injury. Schwann cells modestly improved axonal regeneration in both isografts and allografts and may have a clinical role in the treatment of peripheral nerve allografts. © 2000 Wiley‐Liss, Inc. MICROSURGERY 20:314–323 2000

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Expression of major histocompatibility complex antigens on inflammatory peripheral nerve lesions

Cited by 39 publications

References 35 publications

Expression of major histocompatibility complex class I antigens in the demyelinating twitcher CNS and PNS

Expression of major histocompatibility complex class I antigens in the demyelinating twitcher CNS and PNS

Effects of Schwann cells and donor antigen on long-nerve allograft regeneration

Safe injection of cultured Schwann cells into peripheral nerve allografts

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