Expression of ki-67 and p53 in meningiomas

Abstract

Meningiomas account for about 30% of all primary brain tumors. It is difficult to predict the behaviour of meningiomas, and identification of protein markers responsible for the regulation of cell proliferation can be very helpful. The aim of this study was to evaluate immunohistochemical expression of Ki-67 and p53 in 170 meningiomas.A total number of 170 meningioma samples were classified according to WHO, immunohistochemicaly stained for Ki-67 and p53 and analysed using light microscope.Of 170 meningiomas analysed, 142 were grade I, 17 grade II and 11 grade III. Female to male ratio was 1.42:1. Statistically significant correlation was found between tumor grade and Ki-67 (p<0.001). There was significant correlation between Ki-67 levels and tumor subtypes (p=0.009). The optimal cut-off value for Ki-67 was 3.195. Tumors with Ki-67 ≤3.195 were 2 cm smaller than tumors with Ki-67 >3.195. Statistically significant correlation was found regarding p53 expression and tumor size (p=0.034). No correlation was established between Ki-67 or p53 and location of the tumor.According to positive correlation between tumor grade and subtype with Ki-67 levels, as well as positive correlation between Ki-67 and p53 with tumor size, indicate that Ki-67 and p53 might have influence on meningioma development and progression.

Loss of p53 expression is accompanied by upregulation of beta‐catenin in meningiomas: a concomitant reciprocal expression

“…So, histologically distinct subtypes of benign meningiomas may exhibit high risk of recurrence, even after complete resection (Pavelin et al . ; Narla et al . ), and they also tend to evolve into atypical and anaplastic subtypes (Trott et al .…”

“…variability in the biological behaviour within each of the tumour grades. So, histologically distinct subtypes of benign meningiomas may exhibit high risk of recurrence, even after complete resection (Pavelin et al 2013;Narla et al 2014), and they also tend to evolve into atypical and anaplastic subtypes (Trott et al 2015). Thus, it is clinically important to reveal the molecular characteristics of these tumours.…”

Visual qualitative evaluation of diffusion-weighted imaging, apparent diffusion coefficient quantification and Ki-67 proliferation index for predicting atypia in surgical meningiomas

“…Based on ROC curve analysis the cut-off level of Ki-67 was 3.5%, which is the level of Ki-67 where a bright signal could be expected. [10]. The incidences of grade I (low-grade), grade II (atypical), and grade III (anaplastic) meningiomas have been reported as 90%, 5-7%, and 1-2%, respectively [11].…”

“…Histologic specimens of all patients were evaluated by an 18-year-experienced pathologist (OY). Meningiomas were classified and graded according to the most recent World Health Organization (WHO) 2007 classification of tumors of the central nervous system [10].…”

MKI67 (marker of proliferation Ki-67)

“…Note MKI67 is believed to have some influence in meningioma development and progression since there is significant correlation between its expression and tumor grade, certain subtypes, tumor recurrence and size (Pavelin et al, 2013;Wang et al, 2010a). Another interesting correlation was proposed by Uzum and Ataoglu (2008) in which the tumor grade is the most important prognostic factor of meningiomas, which in turn is significantly correlated with MKI67 expression.…”