Expression of interferon-gamma receptors and interferon-gamma-induced up-regulation of intercellular adhesion molecule-1 in basal cell carcinoma; decreased expression of IFN-γR and shedding of ICAM-1 as a means to escape immune surveillance

Kooy, Angela J. W.; Tank, Bhupendra; Vuzevski, V. D.; Joost, Theodoor van; Prens, Errol P.

doi:10.1002/(sici)1096-9896(199802)184:2<169::aid-path976>3.0.co;2-g

Cited by 35 publications

(7 citation statements)

References 27 publications

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“…Virtually every tumor cell in both small and large islands of invasive BCC was Id‐1 positive. As previously reported (16–18), tumor cells in BCC were devoid of either ICAM‐1 or HLA‐DR, even though the surrounding stromal cells expressed both ICAM‐1 and HLA‐DR (data not shown).…”

Section: Resultssupporting

confidence: 83%

“…As we observed that cultured keratinocytes overexpressing Id‐1 had markedly reduced IFN‐γ‐mediated induction of two different immunomodulatory surface antigens (i.e. class II major histocompatibility complex HLA‐DR; as well as intercellular adhesion molecule‐1, ICAM‐1; CD154), the lack of both these surface proteins in BCC (16–18) suggested a possible link to Id‐1.…”

Section: Introductionmentioning

confidence: 84%

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Role for Id‐1 in immunobiology of normal keratinocytes and in basal cell carcinoma

Chaturvedi¹,

Bonish²,

Bacon³

et al. 2003

Experimental Dermatology

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It has been established that Id proteins can block the basic helix-loop-helix (HLH) transcription factors, thereby impacting the onset of senescence in keratinocytes, as well as influencing tumorigenesis involving squamous cell carcinomas. However, the ability of Id-1 to influence the immunologic response of epithelial cells to cytokines implicated in cutaneous oncology such as gamma interferon (IFN-gamma) has not been determined. Using a whole population of human keratinocytes infected with a retrovirus to induce over-expression of Id-1, the influence on early differentiation of rapidly proliferating keratinocytes was assessed, as was the response to IFN-gamma. While induction of involucrin, a marker of early differentiation, was not altered in Id-1 overexpressing keratinocytes, the IFN-gamma mediated increase in intercellular adhesion molecule-1 (ICAM-1) and HLA-DR was reduced. No change in constitutive or inducible levels of MHC class I antigen, CD95 (Fas antigen) or LFA-3 (CD58) was observed in this system. Immunostaining and Western blot analysis revealed over-expression of Id-1 in basal cell carcinomas (BCCs). These tumors not only strongly and diffusely expressed Id-1, but were also characterized by reduced ICAM-1 and HLA-DR expression. Thus, dysregulated Id-1 may not only contribute to delaying the senescence program in keratinocytes, it may also contribute to the escape of the relatively undifferentiated tumor cells in BCC from immune surveillance.

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Section: Resultssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 84%

Role for Id‐1 in immunobiology of normal keratinocytes and in basal cell carcinoma

Chaturvedi¹,

Bonish²,

Bacon³

et al. 2003

Experimental Dermatology

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“… 24 Several authors have documented a distinct lack of ICAM‐1 on BCC cells. 25–27 However, expression could be induced by incubation with recombinant human IFN‐γ 25,27 …”

Section: Discussionmentioning

confidence: 99%

Cytokine profiles in spontaneously regressing basal cell carcinomas

Wong

Bishop

Lowes

et al. 2000

British Journal of Dermatology

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“…30%. There is an accentuation of Ki67+ cells at the edge of BCC islands, indicating increased proliferative activity at the front of invasion nantly of T cells [4,5,8,14]. In the majority of BCCs, CD4+ cells are more numerous than CD8+ cells; however, some BCCs show a preponderance of CD8+ cells.…”

Section: Discussionmentioning

confidence: 54%

“…1-3), possibly because intercellular adhesion molecule 1 (ICAM-1) is lacking on BCC cells [5,14]. BCCs have been shown to evade T cell response by secreting interkeukin-10 [13], by shedding ICAM-1 or by down-regulation of interferon γ receptors (and thus HLA-class II antigens) [14]. Besides T cells, B cells, NK cells, Langerhans cells, and mast cells can be found to a variable degree [4,8].…”

Section: Discussionmentioning

confidence: 99%

Immunology and growth characteristics of ocular basal cell carcinoma

Rohrbach

Stiemer

Mayer

et al. 2001

Graefe's Arch Clin Exp Ophthalmol

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CD4+ T cells seem to be the most important cell population for BCC immunosurveillance, offering the chance for conservative interferon therapy. The role of CD68+ and HECA-452+ cells has to be further elucidated. In many tumours the large amount of proliferating cells contrasts to the usually slow growth of BCCs, indicating strong apoptotic processes. The results can be regarded only as semiquantitative. So far, ocular and nonocular BCCs exhibit no essential differences regarding immunocompetent cell infiltration and growth characteristics. According to this, palpebral BCCs are "normal" BCCs and not a special BCC variant. Therefore, results from dermatological research concerning BCC can be extended without limitations to their counterparts in the lid area.

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Expression of interferon-gamma receptors and interferon-gamma-induced up-regulation of intercellular adhesion molecule-1 in basal cell carcinoma; decreased expression of IFN-γR and shedding of ICAM-1 as a means to escape immune surveillance

Cited by 35 publications

References 27 publications

Role for Id‐1 in immunobiology of normal keratinocytes and in basal cell carcinoma

Role for Id‐1 in immunobiology of normal keratinocytes and in basal cell carcinoma

Cytokine profiles in spontaneously regressing basal cell carcinomas

Immunology and growth characteristics of ocular basal cell carcinoma

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