Cytokine profiles in spontaneously regressing basal cell carcinomas

Abstract

These findings support a role for T-helper 1 type cytokines in mediating spontaneous regression of BCCs.

Tumor Stroma–Derived Wnt5a Induces Differentiation of Basal Cell Carcinoma of Ptch-Mutant Mice via CaMKII

“…The spontaneous regression of these as well as of other tumors carries a great therapeutic potential, but the knowledge of the underlying mechanisms remains very limited. In BCC, tumor regression has been associated with cells of the immune system and certain cytokines (4,5), but the understanding of this phenomenon is incomplete.…”

Mechanisms Underlying Imiquimod-Induced Regression of Basal Cell Carcinoma In Vivo

“…4 Basal cell carcinoma tends to grow slowly and rarely metastasizes. Additionally, BCC can spontaneously regress, exhibiting a shift in immune response toward a T H 1 profile, 5,6 which See also page 1347 in turn suggests that the immune system plays an active role in BCC surveillance. 4 Immune response in BCC can be modulated by intralesional injections of interferons or by topical application of imiquimod, each resulting in complete clearance of the tumor.…”

The Role of Cytokines and Chemokines in the Development of Basal Cell Carcinoma

“…Some cases of BCC may show spontaneous regression in the absence of therapy. Such spontaneous regression is mediated by activated CD4+ T cells, and IFN-γ is elevated in actively regressing BCC (28). There is a significantly increased number of CD4+ T cells infiltrating regressing tumors, and the expression of IL-2 receptor, which is an early activation marker for T cells is also increased (29).…”