Expression of immunohistochemical markers according to histological type in patients with early gastric cancer

Han, Jae Pil; Hong, Su Jin; Kim, Hee Kyung; Kim, Hyun Su; Lee, Yun Nah; Lee, Tae Hee; Lee, Joon Seong

doi:10.3109/00365521.2015.1065510

Cited by 9 publications

(7 citation statements)

References 30 publications

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“…In the present study, two patients with poor differentiation showed loss of E-cadherin expression, but it was difficult to perform statistical analysis owing to the small number of cases. According to a recent report, loss of E-cadherin expression and overexpression of VEGF are more common with poor histological differentiation in patients with EGC [15].…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue

2019

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Background/AimsEpithelial-mesenchymal transition (EMT) is a developmental process, wherein the epithelial cells show reduced intercellular adhesions and acquire migratory fibroblastic properties. EMT is associated with downregulation in epithelial marker expression, abnormal translocation of E-cadherin, and upregulation in mesenchymal marker expression. Here, we investigated the immunohistochemical (IHC) expression of EMT markers in early gastric cancer (EGC) between cancer and noncancer tissues. MethodsTissue samples were prospectively obtained from 19 patients with EGC that underwent endoscopic submucosal dissection (ESD). We compared the expression level of transforming growth factor (TGF)-β, vascular endothelial growth factor (VEGF), E-cadherin, α-smooth muscle actin (α-SMA), and vimentin between cancer and noncancer tissues using IHC. Among the 19 patients, 15 patients had follow-up biopsy at 3 months after ESD for EGC. ResultsCancer tissues presented higher values of EMT mesenchymal markers (α-SMA/vimentin/TGF-β/VEGF) than the noncancerous tissues (p<0.05) that were significantly low after ESD (p<0.05). No significant correlation was reported for tumor location and initial Helicobacter pylori infection. ConclusionsThe mesenchymal expression of EMT markers was higher in the cancerous tissues than in the noncancer tissues.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue

2019

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“…Park et al reported that GC that had both intestinal and diffuse types had a significantly higher enhanced CpG island hypermethylation status associated with tumor suppressive genes. More recently, Han et al demonstrated that the poorly cohesive components of mixed adenocarcinoma showed decreased E‐cadherin and β‐catenin expression levels and increased vascular endothelial growth factor expression. They discussed that the results indicated these characteristics might contribute to the poor prognosis of patients with mixed adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Early signet ring cell carcinoma of the stomach is related to favorable prognosis and low incidence of lymph node metastasis

et al. 2016

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“…Based on the combinations of expression of these markers, the 257 EGCs were classified into the G-type (21 %, 54/257), GI-type (56 %, 144/257), I-type (20 %, 51/ 257) and N-type (3 %, 8/257); in previous reports, the incidence percentages of each of these mucin phenotypes were found to be 15-41.1 %, 20.3-60.1 %, 18.5-46.6 %, and 3.7-31.6 %, respectively, in advanced GCs [3,13,14], and 7.9-36.8 %, 18.8-41.2 %, 15.4-55.56 %, and 0-11.1 %, respectively, in early-stage GCs [7,11,[19][20][21][22][23][24][25]. Our results were consistent with these studies.…”

Section: Discussionmentioning

confidence: 99%

Gastric mucin phenotype indicates aggressive biological behaviour in early differentiated gastric adenocarcinomas following endoscopic treatment

et al. 2021

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Background The distribution of mucin phenotypes and their relationship with clinicopathological features in early differentiated gastric adenocarcinomas in a Chinese cohort are unknown. We aimed to investigate mucin phenotypes and analyse the relationship between mucin phenotypes and clinicopathological features, especially biological behaviours, in early differentiated gastric adenocarcinomas from endoscopic specimens in a Chinese cohort. Methods Immunohistochemical staining of CD10, MUC2, MUC5AC, and MUC6 was performed in 257 tissue samples from patients with early differentiated gastric adenocarcinomas. The tumour location, gross type, tumour size, histological type, depth of invasion, lymphovascular invasion, mucosal background and other clinicopathological parameters were evaluated. The relationship between mucin phenotypes and clinicopathological features was analysed with the chi-square test. Results The incidences of gastric, gastrointestinal, intestinal and null phenotypes were 21 %, 56 %, 20 and 3 %, respectively. The mucin phenotypes were related to histology classification (P < 0.05). The proportion of the gastric phenotype became greater during the transition from differentiated to undifferentiated (P < 0.05). Complete intestinal metaplasia was higher in the gastric and intestinal phenotypes than in the gastrointestinal phenotype (P < 0.05). Tumours with poorly differentiated adenocarcinoma were mainly of the gastric phenotype, which was significantly higher than that of purely differentiated tubular adenocarcinoma (P < 0.05), and the depth of invasion in the mixed type was deeper (P < 0.05). Neither recurrence nor metastasis was detected. Conclusions The mucin phenotype of early-differentiated gastric adenocarcinoma has clinical implications, and the gastric phenotype has aggressive biological behaviour in early differentiated gastric cancers, especially in those with poorly differentiated adenocarcinoma or papillary adenocarcinoma components.

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Expression of immunohistochemical markers according to histological type in patients with early gastric cancer

Cited by 9 publications

References 30 publications

Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue

Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue

Early signet ring cell carcinoma of the stomach is related to favorable prognosis and low incidence of lymph node metastasis

Gastric mucin phenotype indicates aggressive biological behaviour in early differentiated gastric adenocarcinomas following endoscopic treatment

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