Expression of hypoxia inducible factor—1 alpha and correlation with preoperative embolization of meningiomas

Abstract

The expression of HIF-1alpha is increased by complete preoperative embolization of meningiomas. The expression of HIF-1alpha also correlates with VEGF secretion in meningiomas. Growth factor and hypoxic stimulation both contribute to VEGF control, but which is most important (or whether both are equally important) will require further studies.

Cavernous Sinus Dural Arteriovenous Fistula Associated With the Development of Sphenoidal Ridge Meningioma -Case Report-

“…7,14) Hypoxia inducible factor or vascular endothelial growth factor have been implicated in meningioma tumorigenesis and growth. 7) Such diverse angiogenic factors have been experimentally confirmed to induce the expression of angiogenesis, which is another potential cause of cavernous CS dural AVF. 16) CS dural AVF associated with tumor is a rare clinical entity, but should be considered in patients with tumor or vascular anomaly surrounding the CS.…”

Expression of hypoxia inducible factor-1α in tumors of patients with glioblastoma multiforme and transitional meningioma

“…[13][14][15][16][17][18][19][20] Although HIF-1a expression in common human tumors including glioblastoma multiforme (grade-IV astrocytoma-GBM) is well established, [9][10][11][12]21,22 there is little information about HIF-1a expression in meningioma. 23 In this study, we examined the expression of HIF-1a in GBM and transitional meningioma (TM) and we compared the results for these two types of brain tumor.…”

Preoperative Embolization of Intracranial Meningiomas: Efficacy, Technical Considerations, and Complications

“…2 Branches of the internal carotid artery and pial feeders supplying the tumor may also be embolized, [3][4][5][6] though these vessels are typically more difficult to access and are associated with a higher risk of parenchymal infarct. In an attempt to change the tumor characteristics to increase the likelihood of a gross total resection and minimize operative morbidity, a variety of embolization materials have been used, including polyvinyl alcohol (PVA) particles, 7,8 large-caliber microspheres, 8,9 ethylene-vinyl alcohol (Onyx; Covidien, Irvine, California), causes changes in protein expression consistent with angiogenesis and promotion of growth, 16 along with cytologic changes, including infiltration of macrophages. 17 The combination of these changes may make histologic examination of embolized meningiomas more difficult because they may histopathologically resemble higher grade tumors.…”