Indirect decompression of spinal stenosis can be achieved with lateral transpsoas interbody fusion with improved clinical outcomes. Pre-op and post-op MRI scans showed a significant increase in dural sac dimensions. The mechanism for this indirect decompression may relate to stretching and unbuckling of the spinal ligaments and a decrease in intervertebral disc bulging. Further studies are needed to determine which stenosis patients undergoing this surgery are most appropriate for indirect decompression alone over laminectomy.
BACKGROUND AND PURPOSE:Preoperative embolization for intracranial meningiomas offers potential advantages for safer and more effective surgery. However, this treatment strategy has not been examined in a large comparative series. The purpose of this study was to review our experience using preoperative embolization to understand the efficacy, technical considerations and complications of this technique.
BACKGROUND AND PURPOSE:As aneurysms arising from the ophthalmic segment of the internal carotid artery increase in size, they can compress the optic nerve, prompting patients to present with visual disturbances. The purpose of this article is to describe the clinical and angiographic results with an emphasis on visual outcomes following the endovascular treatment of ophthalmic segment ICA aneurysms.
Introduction
Stenting techniques such as stent-assisted coiling and flow diversion are increasingly used for treatment of intracranial aneurysms. In previous reports, patients were pretreated were aspirin and clopidogrel prior to the intervention for prevention of thromboembolic complications. Prior studies also often rely on aspirin response and P2Y assessment, which often delays treatment in non-responders. The present study assesses the safety and efficacy of a new protocol for anticoagulation using tirofiban during stent-assisted coiling and flow diversion of intracranial aneurysms.
Methods
In this prospective study, all patients received a 0.10 mcg/kg/min maintenance infusion of tirofiban intraoperatively without a loading dose. The infusion was started immediately after deployment of the stent or flow diverter and continued for 12 h following the procedure. No patient was pretreated with aspirin or clopidogrel. Data on procedural safety was prospectively collected.
Results
A total of 128 aneurysms were treated with this protocol. Mean patient age was 56.2 years. Of these patients, 82 underwent stent-assisted coiling and 46 underwent flow diversion with the Pipeline Embolization Device (PED). Twenty-eight patients (22%) were treated in the setting in subarachnoid haemorrhage. There were only 2 (1.6%) thromboembolic complications and 2 (1.6%) haemorrhagic complications (1 subclinical worsening of the computed tomographic appearance of a subarachnoid haemorrhage and 1 post-PED parietal haemorrhage that was managed conservatively) in the series. The rate of treatment-related permanent morbidity and mortality were only 0.8% and 0%, respectively.
Conclusion
The results of this study suggest that a protocol of anticoagulation with a maintenance infusion of tirofiban during stent-assisted coiling and flow diversion of intracranial aneurysms has an excellent safety profile. This protocol provides a reasonable alternative to pre-treating with aspirin and clopidogrel. The protocol is also particularly useful in patients with ruptured aneurysms or when the use of a stent was unexpected.
Disclosures
N. Chalouhi: None. M. Zanaty: None. R. Starke: None. P. Jabbour: None. D. Hasan: None.
changed. Rates of wrapping, residua, and regrowth were not statistically different based on aneurysm rupture status. Conclusion Open surgery for cerebral aneurysm results in incomplete treatment approximately 12% of the time. This should be taken into account when considering endovascular verses open surgical therapy and counseling patients. These results should be interpreted with caution considering the significant amount of heterogeneity between the included studies.
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