Expression of histidine decarboxylase messenger RNA and histamine N‐methyltransferase messenger RNA in nasal allergy

Hirata,; Takéuchi,; Ukai,; Sakakura,

doi:10.1046/j.1365-2222.1999.00345.x

Cited by 22 publications

(26 citation statements)

References 42 publications

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“…Synthesis of histamine by HDC plays another important regulatory step in histamine signaling. HDC mRNA is increased in nasal mucosa of patients with AR (49). The finding that expression of HDC mRNA, HDC activity, and the histamine content of the nasal mucosa were significantly increased after TDI provocation indicates the importance of HDC in allergic responses (13).…”

Section: Discussionmentioning

confidence: 73%

Suplatast Tosilate Inhibits Histamine Signaling by Direct and Indirect Down-Regulation of Histamine H1 Receptor Gene Expression through Suppression of Histidine Decarboxylase and IL-4 Gene Transcriptions

Shahriar

Mizuguchi

Maeyama

et al. 2009

The Journal of Immunology

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Allergic rhinitis (AR) is an inflammatory disorder typified by symptoms such as sneezing, congestion, and rhinorrhea. Histamine plays important roles in eliciting AR symptoms. Up-regulation of the histamine H1 receptor (H1R) and histidine decarboxylase (HDC) mRNAs was observed in AR patients. Th2 cytokines are also involved in the pathogenesis of AR. We examined the effect of suplatast tosilate on nasal symptoms, and H1R, HDC, and IL-4 gene expression using toluene-2,4-diisocyanate (TDI)-sensitized rats and HeLa cells expressing endogenous H1R. Provocation with TDI increased nasal symptoms, HDC activity, the histamine content of nasal lavage fluid, and the expression of H1R, HDC, and IL-4 mRNAs in TDI-sensitized rats. Pretreatment with suplatast for 2 wk significantly suppressed TDI-induced nasal symptoms and elevation of H1R, HDC, and IL-4 mRNAs. Suplatast also suppressed HDC activity in the nasal mucosa and the histamine content of the nasal lavage fluid. Bilateral injection of IL-4 into the nasal cavity of normal rats up-regulated H1R mRNA, while intranasal application of histamine up-regulated IL-4 mRNA. Suplatast suppressed IL-4-induced up-regulation of H1R mRNA in HeLa cells. However, it did not inhibit histamine-induced H1R mRNA elevation. These results suggest that suplatast alleviates nasal symptoms by inhibiting histamine signaling in TDI-sensitized rats through the suppression of histamine- and IL-4-induced H1R gene expression by the inhibitions of HDC and IL-4 gene transcriptions, respectively.

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Section: Discussionmentioning

confidence: 73%

Suplatast Tosilate Inhibits Histamine Signaling by Direct and Indirect Down-Regulation of Histamine H1 Receptor Gene Expression through Suppression of Histidine Decarboxylase and IL-4 Gene Transcriptions

Shahriar

Mizuguchi

Maeyama

et al. 2009

The Journal of Immunology

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“…Many studies have shown that activation of H1R by histamine is responsible for the symptoms of allergic rhinitis, including sneezing, watery rhinorrhea, and nasal itching, and the high efficacy of antihistamines in controlling nasal hypersensitivity symptoms in the eliciting/effecter phase of nasal allergy (34 -37). In eukaryotes, HDC is the sole enzyme responsible for synthesizing histamine and consequently regulation of the HDC activity is a crucial step for histamine biosynthesis (38).…”

Section: Introductionmentioning

confidence: 99%

Kujin Suppresses Histamine Signaling at the Transcriptional Level in Toluene 2,4-Diisocyanate–Sensitized Rats

et al. 2009

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Abstract. Kujin, the dried root of Sophorae flavescensis, has been used in Chinese folklore medicine against allergy. Evaluation of its anti-allergic potential as well as its mechanism of action has rarely been established. We investigated the effect of Kujin on toluene-2,4-diisocyanate (TDI)-induced allergic behavior and related histamine signaling including mRNA levels of histamine H 1 receptor (H1R) and histidine decarboxylase (HDC), H1R and HDC activities, and histamine content in rat nasal mucosa. We also investigated the effect of Kujin on the mRNA levels of helper T cell type 2 (Th2)-cytokine genes closely related to histamine signaling. TDI provocation caused acute allergic symptoms accompanied with up-regulations of H1R and HDC mRNAs and increases in HDC activity, histamine content, and [ 3 H]mepyramine binding activity in the nasal mucosa, all of which were significantly suppressed by pretreatment with Kujin for 3 weeks. Kujin also suppressed the TDI-induced IL-4 and IL-5 mRNA elevations. These data suggest that oral administration of Kujin showed anti-allergic activity through suppression of histamine signaling by the inhibition of TDI-induced H1R and HDC mRNA elevations followed by decrease in H1R, HDC protein level, and histamine content in the nasal mucosa of TDI-sensitized rats. Suppression of Th2-cytokine signaling by Kujin also suggests that it could affect the histamine-cytokine network.

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“…HDC mRNA expression was increased in the nasal mucosa of Japanese patients with allergic rhinitis compared to those without the disease [17]. A study by Gervasini, et a.l, which included HDC nonsynonymous SNPs, (HDC 1932 A/C (Glu644Asp, rs2073440) and HDC 92C/T (Thr31Met, rs17740607)) and newly identified synonymous SNPs (rs854163, rs35047996) was conducted in a well-defined allergic phenotype population of Caucasian subjects from Spain.…”

Section: Discussionmentioning

confidence: 99%

“…Although the functional significance of many of these SNPs is unknown, several studies have been conducted to explore potential associations between histamine related genes and asthma and allergic disease [6,17,[33][34][35][36][37][38][39][40][41][42][43]. We have previously reported that the HRH1 gene was more highly expressed in buccal tissue from those with asthma compared to those without asthma [44].…”

Section: Introductionmentioning

confidence: 99%

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Genetic Variation Along The Histamine Pathway In Children With Allergic Vs. Non-Allergic Asthma

Anvari

Vyhlidal

Rezaiekhaligh

et al. 2014

Journal of Allergy and Clinical Immunology

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ABSTRACT:Rationale: Previous studies have suggested that antihistamines may be therapeutic in some patients with asthma. Variation in genes along the histamine production, response, and degradation pathway may be important in predicting response to antihistamines. We hypothesize that genetic variation in genes of the histamine pathway differs between children with allergic versus non-allergic asthma.Methods: Children 7-18 years of age (n=118) with asthma participated in this IRB-approved protocol and were classified as allergic (N = 68) or non-allergic (N = 50) based on allergy skin testing. DNA isolation and genotyping were performed for 10 SNPs within 4 genes (HDC, HNMT, ABP1, HRH1, HRH4) within the histamine pathway. Chi Square tests were used to test for associations between genotypes and allergic or non-allergic asthma among participants.Significance was determined by p <0.05. Results:We observed differences in genotype frequency between participants with allergic versus non-allergic asthma for 2 SNPs: HNMT-1639(rs6430764) (31% allergic with TT vs. 14% non-allergic with TT, p=0.04) and HNMT -464 (rs2071048) genotype (33% allergic with TT vs.12% non-allergic with TT, p=0.03) after controlling for race. Differences in genotype frequency were also observed between allergic and non-allergic phenotypes in stratified analyses among African Americans. Conclusion:Genetic variants within the histamine pathway appear to be associated with an allergic versus non-allergic asthma phenotype. Further studies are needed to validate our findings in a larger cohort. There is also the need to determine the functional significance of identified SNPs and their impact on antihistamine response in patients with asthma and allergic disease. iv ACKNOWLEDGMENTS:

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Expression of histidine decarboxylase messenger RNA and histamine N‐methyltransferase messenger RNA in nasal allergy

Abstract: Increased HDC mRNA expression and decreased HMT mRNA expression may be playing some role in the hyperresponsiveness of patients with allergic rhinitis.

Cited by 22 publications

References 42 publications

Suplatast Tosilate Inhibits Histamine Signaling by Direct and Indirect Down-Regulation of Histamine H1 Receptor Gene Expression through Suppression of Histidine Decarboxylase and IL-4 Gene Transcriptions

Suplatast Tosilate Inhibits Histamine Signaling by Direct and Indirect Down-Regulation of Histamine H1 Receptor Gene Expression through Suppression of Histidine Decarboxylase and IL-4 Gene Transcriptions

Kujin Suppresses Histamine Signaling at the Transcriptional Level in Toluene 2,4-Diisocyanate–Sensitized Rats

Genetic Variation Along The Histamine Pathway In Children With Allergic Vs. Non-Allergic Asthma

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