Expression of histamine H 1 receptor in placenta

Matsuyama, Kazuto; Kawakami, Nozomi; Ichikawa, Tomoyuki; Nitta, Y; Ishimura, K.; Horio, Shuhei; Fukui, Hirokazu

doi:10.1007/s00011-003-0341-2

Cited by 3 publications

(2 citation statements)

References 3 publications

(2 reference statements)

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“…PCR was performed using a GeneAmp PCR system 2400 (Perkin Elmer, Waltham, Mass., USA). In addition, 20 l of amplified product was electrophoretically separated in 1.5% (w/v) agarose gel [16][17][18][19][20][21] .…”

Section: Reverse Transcription Polymerase Chain Reactionmentioning

confidence: 99%

Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

Morimitsu

Sato

Kotani

et al. 2009

Gynecol Obstet Invest

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Background/Aims: Previous studies have stated that maternal allergic diseases are associated with increased risk of preterm labor/delivery, but the underlying mechanisms remain unclear. This study tested the hypothesis that histamine induces interleukin (IL)-6 production in amnion cells. Methods: Using cultured human amnion cells, we examined expression of histamine receptors and effects of histamine on IL-6 production. Results: Reverse transcription-polymerase chain reaction and Western blotting revealed expression of histamine H1 receptor (H1R) and H2 receptor (H2R) in human amnion. Histamine stimulation significantly increased concentrations of IL-6 in conditioned medium, as did tumor necrosis factor-α and IL-1β in positive controls. In addition, the H1R antagonist olopatadine significantly blocked histamine-induced production of IL-6, whereas the H2R antagonist ranitidine did not. Conclusion: Histamine appears to induce IL-6 production through H1R in human amnion cells.

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Section: Reverse Transcription Polymerase Chain Reactionmentioning

confidence: 99%

Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

Morimitsu

Sato

Kotani

et al. 2009

Gynecol Obstet Invest

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“…Therefore, in the present study we investigated the expression of H 1 R in the human placenta tissue to localize H 1 R expression and identify H 1 R-containing cells by immunohistochemical study using an antibody against human H 1 R. Some of these results have appeared in preliminary form (18). …”

Section: Introductionmentioning

confidence: 99%

Localized Expression of Histamine H1 Receptors in Syncytiotrophoblast Cells of Human Placenta

et al. 2006

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Abstract. The previous Northern blot analysis and in situ hybridization studies showed that histamine H 1 -receptor (H 1 R) mRNA is expressed in human placenta and suggested that H 1 R plays some roles in the function of placenta in pregnancy. To investigate further, it is essential to show the precise location of H 1 R in the placenta. In the present study, we investigated H 1 R expression in human placenta by radioligand binding assay and immunohistochemical study using an antibody against human H 1 R. Placentas were obtained from normal uncomplicated deliveries. Membranes prepared from the tissue exhibited saturable [

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Effects of histamine and diamine oxidase activities on pregnancy: a critical review

Maintz¹,

Schwarzer²,

Bieber³

et al. 2008

Human Reproduction Update

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Expression of histamine H 1 receptor in placenta

Cited by 3 publications

References 3 publications

Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

Localized Expression of Histamine H1 Receptors in Syncytiotrophoblast Cells of Human Placenta

Effects of histamine and diamine oxidase activities on pregnancy: a critical review

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