Localized Expression of Histamine H1 Receptors in Syncytiotrophoblast Cells of Human Placenta

Matsuyama, Kazuto; Ichikawa, Tomoyuki; Nitta, Y; Ikoma, Yoshio; Ishimura, K.; Horio, Shuhei; Fukui, Hirokazu

doi:10.1254/jphs.fp0060862

Cited by 6 publications

(9 citation statements)

References 42 publications

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“…Mean ( 8 standard error of the mean) histamine content of the myometrium has been reported as 2.1 8 0.3 g/g of tissue. With regard to the uteroplacental interface, Matsuyama et al [20] reported expression of H1R in human syncytiotrophoblast cells and Brew and Sullivan et al [31] reported H1R and H2R expressions in human decidua. However, the existence of histamine receptors in human amnion has not previously been reported.…”

Section: Discussionmentioning

confidence: 99%

Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

Morimitsu

Sato

Kotani

et al. 2009

Gynecol Obstet Invest

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Background/Aims: Previous studies have stated that maternal allergic diseases are associated with increased risk of preterm labor/delivery, but the underlying mechanisms remain unclear. This study tested the hypothesis that histamine induces interleukin (IL)-6 production in amnion cells. Methods: Using cultured human amnion cells, we examined expression of histamine receptors and effects of histamine on IL-6 production. Results: Reverse transcription-polymerase chain reaction and Western blotting revealed expression of histamine H1 receptor (H1R) and H2 receptor (H2R) in human amnion. Histamine stimulation significantly increased concentrations of IL-6 in conditioned medium, as did tumor necrosis factor-α and IL-1β in positive controls. In addition, the H1R antagonist olopatadine significantly blocked histamine-induced production of IL-6, whereas the H2R antagonist ranitidine did not. Conclusion: Histamine appears to induce IL-6 production through H1R in human amnion cells.

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Section: Discussionmentioning

confidence: 99%

Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

Morimitsu

Sato

Kotani

et al. 2009

Gynecol Obstet Invest

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“…Acquisition of the samples was performed in the presence of trypan blue (200 g/ml) to quench extracellular fluorescence. (29). For saturation studies, increasing concentrations of [ 3 H]mepyramine, ranging from 0.01 to 15 nM, were incubated with 10 6 cells/tube, in the absence or presence of 10 M mepyramine, in a total volume of 100 l. After 40 min at 4°C, incubation was stopped by dilution with 3 ml of ice-cold 50 mM Tris-HCl (pH 7.4) and rapid filtration under reduced pressure onto Whatman GF/B glass-fiber filters, followed by three washes with 3 ml of ice-cold buffer.…”

Section: Phagocytosis Of Fitc-ova-coated Latex Beadsmentioning

confidence: 99%

Histamine Improves Antigen Uptake and Cross-Presentation by Dendritic Cells

Amaral

Davio

Ceballos

et al. 2007

The Journal of Immunology

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Previous studies have shown that histamine is able to modulate the function of dendritic cells (DCs). Histamine seems to be required for the normal differentiation of DCs. Moreover, it is capable of stimulating the chemotaxis of immature DCs and of promoting the differentiation of T CD4+ cells into a Th2 profile. In this study, we analyzed whether histamine was able to modulate endocytosis and cross-presentation mediated by immature DCs. Our results show that both functions are stimulated by histamine. Endocytosis of soluble HRP and FITC-OVA and cross-presentation of soluble OVA were markedly increased by histamine. Interestingly, stimulation of endocytosis and cross-presentation appeared to be mediated through different histamine receptors. In fact, the enhancement of endocytosis was prevented by the histamine2 receptor (H2R) antagonist cimetidine, whereas the stimulation of cross-presentation was prevented by the H3R/H4R antagonist thioperamide. Of note, contrasting with the observations made with soluble Ags, we found that histamine did not increase either the uptake of OVA-attached to latex beads, or the cross-presentation of OVA immobilized on latex beads. This suggests that the ability of histamine to increase endocytosis and cross-presentation is dependent on the Ag form and/or the mechanisms through which the Ag is internalized by DCs. Our results support that histamine may favor cross-presentation of soluble allergens by DCs enabling the activation of allergen-specific T CD8+ cells, which appears to play an important role in the development of allergic responses in the airway.

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“…The biologic mechanism through which antihistamines inhibit the actions of histamine may affect both implantation and uterine contraction. Histamine is a monoamine that impacts several cellular pathways in the female reproductive system, as it is produced by uterine mast cells, uterine epithelial cells, and the placenta . The action of histamine is mediated through four subtypes of histamine receptors: H1, H2, H3, and H4 receptors .…”

Section: Introductionmentioning

confidence: 99%

“…The action of histamine is mediated through four subtypes of histamine receptors: H1, H2, H3, and H4 receptors . Of particular interest are the H1 and H2 receptors, which are expressed in the uterus, placenta, and blastocysts . Stimulation of H1 receptors by agonists leads to smooth muscle contraction, nitric oxide formation for endothelial vasodilation, and increased vascular permeability .…”

Section: Introductionmentioning

confidence: 99%

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First-trimester antihistamine exposure and risk of spontaneous abortion or preterm birth

Aldridge

Hartmann

Michels

et al. 2014

Pharmacoepidemiol Drug Saf

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Purpose We tested whether antihistamine exposure during early pregnancy is associated with spontaneous abortion (SAB) or preterm birth (PTB). Methods Women were enrolled in Right from the Start (2004-2010), a prospective pregnancy cohort. Data about first-trimester antihistamine use were obtained from screening and first-trimester interviews. Self-reported outcomes included spontaneous abortion and preterm birth and were verified by medical records. Cox proportional hazards models were used to test for an association between antihistamine use and each outcome, both performed adjusting for confounders. Results Among the 2,685 pregnancies analyzed, 14% (n=377) reported use of antihistamines. Among antihistamine users, 12% (n=44) experienced SABs, and 6% (n=21) had PTBs. Antihistamine exposure was not associated with SAB (adjusted hazard ratio [aHR]=0.88, 95% confidence interval [CI] 0.64, 1.21) or PTB, which was modified by maternal race (aHR=1.03, 95% CI 0.61,1.72 among White women and aHR=0.43, 95% CI 0.14, 1.34 among Black women). Conclusions Despite biologic plausibility that antihistamine use may influence pregnancy outcomes, we did not detect evidence of an association with SAB. These data demonstrate the utility of large prospective cohorts for evaluating drug safety in pregnancy when concerns are raised from animal models.

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Localized Expression of Histamine H1 Receptors in Syncytiotrophoblast Cells of Human Placenta

Cited by 6 publications

References 42 publications

Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

Histamine Improves Antigen Uptake and Cross-Presentation by Dendritic Cells

First-trimester antihistamine exposure and risk of spontaneous abortion or preterm birth

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