Expression of hemagglutinin protein of Rinderpest virus in transgenic pigeon pea [Cajanus cajan (L.) Millsp.] plants

Satyavathi, Valluri V.; Prasad, Vinayaka R.; Khandelwal, Abha; Shaila, M.S.; Sita, G. Lakshmi

doi:10.1007/s00299-002-0540-2

Cited by 64 publications

(27 citation statements)

References 38 publications

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“…When inoculated intraperitoneally, transgenic plant derived protein produced high titer antibodies in mice and neutralized RPV infection. Similarly, leaves of transgenic peanut expressing RPV-H when fed to mice and cattle induced neutralizing antibodies and lymphoproliferative response (Khandelwal et al, 2003a(Khandelwal et al, ,b, 2004Satyavathi et al, 2003). Though still at an early stage of development, these studies suggest the potential of the oral edible vaccine against morbillivirus infections.…”

Section: Edible Vaccinementioning

confidence: 98%

Advances in peste des petits ruminants vaccines

Kumar

Barua

Riyesh

et al. 2017

Veterinary Microbiology

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Peste des petits ruminants (PPR) is a highly contagious disease of small ruminants that leads to high morbidity and mortality thereby results in devastating economic consequences to the livestock industry. PPR is currently endemic across most parts of Asia and Africa, the two regions with the highest concentration of poor people in the world. Sheep and goats in particularly contribute significantly towards the upliftment of livelihood of the poor and marginal farmers in these regions. In this context, PPR directly affecting the viability of sheep and goat husbandry has emerged as a major hurdle in the development of these regions. The control of PPR in these regions could significantly contribute to poverty alleviation, therefore, the Office International des Epizooties (OIE) and Food and Agricultural Organization (FAO) have targeted the control and eradication of PPR by 2030 a priority. In order to achieve this goal, a potent, safe and efficacious live-attenuated PPR vaccine with long-lasting immunity is available for immunoprophylaxis. However, the live-attenuated PPR vaccine is thermolabile and needs maintenance of an effective cold chain to deliver into the field. In addition, the infected animals cannot be differentiated from vaccinated animals. To overcome these limitations, some recombinant vaccines have been developed. This review comprehensively describes about the latest developments in PPR vaccines.

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Section: Edible Vaccinementioning

confidence: 98%

Advances in peste des petits ruminants vaccines

Kumar

Barua

Riyesh

et al. 2017

Veterinary Microbiology

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“…It is more effective in dicots than monocots probably because of the differences in quality/quantity of regulatory factors. CaMV35S promoter has been used to produce several antigenic proteins in plants including CTB, LTB, HBsAg, protective antigen, rabies virus glycoprotein G, SARS virus glycoprotein S (Aziz et al, 2005;Jani et al, 2002;Kang et al, 2004c;Li et al, 2006b;McGarvey et al, 1995;Satyavathi et al, 2003) and other products of therapeutic or industrial importance like monoclonal antibodies, spider silk, SMAP-29 peptide, streptavidin, avidin and adiponectin (Berberich et al, 2005;Drake et al, 2003;Hull et al, 2005a;Morassutti et al, 2002;Murray et al, 2002;Scheller et al, 2001;Zeitlin et al, 1998).…”

Section: Constitutive Promotersmentioning

confidence: 99%

Plants as bioreactors: Recent developments and emerging opportunities

Sharma

2009

Biotechnology Advances

214

121

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In recent years, the use of plants as bioreactors has emerged as an exciting area of research and significant advances have created new opportunities. The driving forces behind the rapid growth of plant bioreactors include low production cost, product safety and easy scale up. As the yield and concentration of a product is crucial for commercial viability, several strategies have been developed to boost up protein expression in transgenic plants. Augmenting tissue-specific transcription, elevating transcript stability, tissue-specific targeting, translation optimization and sub-cellular accumulation are some of the strategies employed. Various kinds of products that are currently being produced in plants include vaccine antigens, medical diagnostics proteins, industrial and pharmaceutical proteins, nutritional supplements like minerals, vitamins, carbohydrates and biopolymers. A large number of plant-derived recombinant proteins have reached advanced clinical trials. A few of these products have already been introduced in the market.

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“…Khandelwal and colleagues (Khandelwal et al 2003a(Khandelwal et al , b, 2004Satyavathi et al 2003) have reported attempts to produce a less expensive, yet effective, vaccine by expression of the H protein in transgenic tobacco, peanut, and pigeon pea and oral delivery of the candidate vaccine in a mouse model and in cattle. The H protein expressed in tobacco was immunogenic and elicited a specific humoral response in an experimental mouse model (Khandelwal et al 2003a).…”

Section: Rinderpest Virusmentioning

confidence: 99%

“…Pigeon pea, also known as regram, is used as a food and fodder crop, with the foliage being used for animal feed after the seeds have been harvested for human consumption. Satyavathi et al (2003) transformed pigeon pea with the H protein under transcriptional control of the CaMV 35S promoter. Levels of H protein in transgenic leaves reached 0.49% TSP.…”

Section: Rinderpest Virusmentioning

confidence: 99%

Plant Production of Veterinary Vaccines and Therapeutics

Hammond

Nemchinov

2009

Current Topics in Microbiology and Immunology

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Plant-derived biologicals for use in animal health are becoming an increasingly important target for research into alternative, improved methods for disease control. Although there are no commercial products on the market yet, the development and testing of oral, plant-based vaccines is now beyond the proofof-principle stage. Vaccines, such as those developed for porcine transmissible gastroenteritis virus, have the potential to stimulate both mucosal and systemic, as well as, lactogenic immunity as has already been seen in target animal trials. Plants

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Expression of hemagglutinin protein of Rinderpest virus in transgenic pigeon pea [Cajanus cajan (L.) Millsp.] plants

Cited by 64 publications

References 38 publications

Advances in peste des petits ruminants vaccines

Advances in peste des petits ruminants vaccines

Plants as bioreactors: Recent developments and emerging opportunities

Plant Production of Veterinary Vaccines and Therapeutics

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