Expression of genes for enzymes synthesizing lysophosphatidic acid, its receptors and follicle developmental factors derived from the cumulus-oocyte complex is dependent on the ovarian follicle type in cows

Sinderewicz, Emilia; Grycmacher, Katarzyna; Boruszewska, Dorota; Kowalczyk-Zięba, Ilona; Staszkiewicz-Chodor, Joanna; Łukaszuk, Krzysztof; Wocławek-Potocka, Izabela

doi:10.1016/j.anireprosci.2018.03.018

Cited by 6 publications

(4 citation statements)

References 55 publications

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“…Moreover, the high percentage of large size follicles and corpus luteum in LPA + / LPA - group indicated that LPA stimulates the growth of primordial and primary follicles to subsequent stages by expansion of follicular cells. Similarly, it was shown that LPA induced the proliferation and expansion of several cell types by binding to its receptors and involving in the phosphoinositide 3-kinase ( 25 - 27 ). Abedpour et al showed that four receptors related to LPA are expressed in the mouse ovary and it seems that the same signaling pathway involves during the addition of LPA to the culture medium ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

“…Abedpour et al showed that four receptors related to LPA are expressed in the mouse ovary and it seems that the same signaling pathway involves during the addition of LPA to the culture medium ( 27 ). Sinderewicz et al, postulated that LPA enhanced the growth and development of follicles via expression of LPARs and AX genes ( 20 , 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…LPA has physiological functions in reproductive system including ovary, follicular and early embryo development, fertilization, implantation, pregnancy maintenance and parturition ( 16 , 19 , 22 - 24 ). It acts via its receptors (LPAR1–6) through several subunits of G-protein ( 25 - 27 ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of lysophosphatidic Acid on the Vascular Endothelial Growth Factor Expression in Autotransplanted Mouse Ovaries Encapsulated in Sodium Alginate

Dehghan

Shahbazi

Salehnia

2021

JFRH

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Objective: The aim of this study was to evaluate the effect of lysophosphatidic acid (LPA) supplementation during in vitro culture and transplantation of mouse ovaries on the follicular development and expression of vascular endothelial growth factor (VEGF) as an angiogenesis factor at the mRNA and protein levels. Materials and methods: Three weeks old mice ovaries were cultured in the presence and absence of LPA for 24 hours, then they were capsulated in sodium alginate in the presence and absence of LPA as four experimental groups. After transplantation the vaginal smears were performed daily to evaluate the initiation of the estrous cycle. The morphology and follicular distribution were analyzed at the first and fourth estrous cycles using hematoxylin and eosin staining. Then in the groups that showed higher and lower follicular development the immunohistochemistry assay was conducted to identify VEGF protein expression, and the real time RT-PCR was done to analyze the expression of Vegf gene at the first estrus cycle. Results: The large size follicles and also the corpus luteum were prominent in all transplanted groups at fourth estrus cycle in comparison with intact control groups. The statistically lowest percentage of small size follicles and the highest percentages of large size follicles were seen in LPA+/LPA- group (p<0.05). The expression ratio of Vegf to β-actin was significantly higher in this group in comparison with non-LPA treated and intact control groups (p <0.05). Conclusion: LPA as an angiogenesis factor increases the follicular development in transplanted ovaries but it causes early discharge of ovarian reserve.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of lysophosphatidic Acid on the Vascular Endothelial Growth Factor Expression in Autotransplanted Mouse Ovaries Encapsulated in Sodium Alginate

Dehghan

Shahbazi

Salehnia

2021

JFRH

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“…ATX is also involved in the regulation of the pluripotency transcriptional program, which is mediated by leukemia inhibitory factor (LIF) and bone morphogenetic proteins (BMP) in HSCs [32]. On the other hand, intracellular LPA is synthesized by three enzymes localized in the endoplasmic reticulum (ER) or the mitochondrial membrane: glycerophosphate acyltransferase (GPAT), phospholipase A (PLA), and acylglycerol kinase (AGK) [33][34][35]. Previous studies suggested that PLA2 activity is regulated by cytokines including IL-1, GM-CSF, and TNFα.…”

Section: Lpa Generationmentioning

confidence: 99%

Lysophosphatidic Acid and Hematopoiesis: From Microenvironmental Effects to Intracellular Signaling

Lin

Chiang

et al. 2020

IJMS

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Vertebrate hematopoiesis is a complex physiological process that is tightly regulated by intracellular signaling and extracellular microenvironment. In recent decades, breakthroughs in lineage-tracing technologies and lipidomics have revealed the existence of numerous lipid molecules in hematopoietic microenvironment. Lysophosphatidic acid (LPA), a bioactive phospholipid molecule, is one of the identified lipids that participates in hematopoiesis. LPA exhibits various physiological functions through activation of G-protein-coupled receptors. The functions of these LPARs have been widely studied in stem cells, while the roles of LPARs in hematopoietic stem cells have rarely been examined. Nonetheless, mounting evidence supports the importance of the LPA-LPAR axis in hematopoiesis. In this article, we have reviewed regulation of hematopoiesis in general and focused on the microenvironmental and intracellular effects of the LPA in hematopoiesis. Discoveries in these areas may be beneficial to our understanding of blood-related disorders, especially in the context of prevention and therapy for anemia.

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Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment

Lee

Lin

Balogh

et al. 2021

Cellular Signalling

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Expression of genes for enzymes synthesizing lysophosphatidic acid, its receptors and follicle developmental factors derived from the cumulus-oocyte complex is dependent on the ovarian follicle type in cows

Cited by 6 publications

References 55 publications

Effect of lysophosphatidic Acid on the Vascular Endothelial Growth Factor Expression in Autotransplanted Mouse Ovaries Encapsulated in Sodium Alginate

Effect of lysophosphatidic Acid on the Vascular Endothelial Growth Factor Expression in Autotransplanted Mouse Ovaries Encapsulated in Sodium Alginate

Lysophosphatidic Acid and Hematopoiesis: From Microenvironmental Effects to Intracellular Signaling

Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment

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