Expression of genes associated with inflammation induced by ex vivo exposure to lipopolysaccharide in peripheral blood leukocytes from horses with gastrointestinal disease

Abstract

No evidence existed for a reduced response of leukocytes from horses with gastrointestinal disease to ex vivo exposure to LPS. Leukocyte expression of inflammatory genes after ex vivo incubation with LPS appeared to be related to pathogenesis and prognosis.

Assessment of the impact of age and of blood‐derived inflammatory markers in horses with colitis

“…[13][14][15][16] Similarly, increased lipopolysaccharide-induced IL-10 expression has been documented in nonsurviving horses with gastrointestinal illness. 17 Consequently, a shift from a type-1 to a type-2 immune response in aged horses may impair their ability to combat gastrointestinal disease.…”

Assessment of systemic inflammation by time‐trends of blood granulocyte count and plasma myeloperoxidase and elastase concentrations following colic surgery in horses

“…18 Tissue injury as occurs during colic and surgery may result in systemic neutrophil activation and systemic inflammatory response syndrome. [19][20][21] Systemic inflammatory response syndrome can be seen in horses suffering from colic and postoperative complications, [22][23][24] and can lead to life-threatening problems such as laminitis and renal failure. It has been shown in horses with colic that the kinetics of blood leukocytes during the perioperative period differ with outcome, and that postoperative blood leukocyte counts may predict outcome.…”