Expression of Fibroblast Growth Factors in Exercise-Induced Muscle Hypertrophy with Special Reference to the Role of Muscle Satellite Cells

Yamada, Shigeru; Kimura, Hisakazu; Fujimaki, A.; Strohman, Richard C.

doi:10.1159/000421555

Cited by 4 publications

(1 citation statement)

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“…Yamada et al (35,36) have reported that the level of FGF-II is higher in hypertrophied compared with control muscle and that FGF-II is produced in the walls of endothelial cells and stored in the basal lamina of the muscle fiber, where its activity is neutralized through binding with heparin. They also propose that FGF-II stimulates satellite cell activation and that muscle fiber inflammation and/or alterations of the basal lamina, through fiber damage or mechanical distortion of the muscle fibers, result in perturbation of the normal FGF-II-heparin interaction, allowing FGF-II to become active.…”

Section: Capillarization In Hypertrophied Skeletal Musclementioning

confidence: 99%

Time course of changes in capillarization in hypertrophied rat plantaris muscle

Plyley

Olmstead²,

Noble³

1998

Journal of Applied Physiology

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The time course of angiogenesis during hypertrophy of the rat plantaris muscle was studied by using a unilateral, synergistic ablation model. Animals (n = 6/group) were euthanized 2, 5, 7, 15, 21, and 30 days postmyectomy. Sections from both the hypertrophied and contralateral muscles were simultaneously stained for capillaries and muscle fiber type. Mean fiber cross-sectional area (FA) and various indexes of capillarity were determined by using a video analysis system. The capillary supply to individual fibers, assessed as the FA supplied per capillary contact, remained unchanged until day 21 (compared with day 2) and exhibited a significant increase at day 30. Analysis of the time course of capillary development on the basis of the number of capillary contacts per fiber, and of hypertrophy on the basis of FA, yielded half-lives of 10.1 and 11.2 days, respectively. It was concluded that angiogenesis during muscle overload is tightly coupled to the changes in FA, which could suggest that the two processes are initiated and/or driven by some common factor(s).

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Section: Capillarization In Hypertrophied Skeletal Musclementioning

confidence: 99%

Time course of changes in capillarization in hypertrophied rat plantaris muscle

Plyley

Olmstead²,

Noble³

1998

Journal of Applied Physiology

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Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: an immunohistochemical study

Sakuma

Watanabe

Totsuka

et al. 1998

Acta Neuropathologica

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We investigated changes in several growth factors in the rat plantaris muscle produced by mechanical overloading by ablation of synergists using immunohistochemistry. At 1 and 3 days post surgery, the insulin-like growth factor-I (IGF-I) level was slightly increased in the cytosol and markedly increased in the invading cells of the extracellular space. Thereafter, the IGF-I immunoreactivity evoked by overloading rapidly decreased to the normal level. The level of leukemia inhibitory factor (LIF), which was not shown to change at 1 day post surgery, was increased in the cytosol at 3, 5, 7 and 10 days and at 2 weeks. Basic fibroblast growth factor (bFGF) immunoreactivity did not change during the entire period of overloading (1 day-3 weeks post surgery). These results indicate that the elevations of the levels of IGF-I and LIF show differential time course in the plantaris muscle subjected to functional overload. Furthermore, bFGF appears not to be related to the compensatory hypertrophy produced by overloading.

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