Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: an immunohistochemical study

Sakuma, Kunihiro; Watanabe, Kimi; Totsuka, Tsuyoshi; Uramoto, Isao; Sano, Mamoru; Sakamoto, Kei

doi:10.1007/s004010050775

Cited by 31 publications

(31 citation statements)

References 29 publications

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“…The inactivation of satellite cells by gamma irradiation prevents muscle hypertrophy following compensatory overload [26,29]. Because FGF-2 and FGF-6 proteins are expressed in adult rat skeletal muscle [16,31,32] and the presence of HGF protein in satellite cells isolated from adult rat muscle has been detected by immunofluorescence [39], the enhanced expression of FGF-2, FGF-6, FGF-7, and HGF during overload in this study may be associated with muscle hypertrophy, possibly by activation of satellite cells.…”

Section: Discussionmentioning

confidence: 99%

mRNA expression of fibroblast growth factors and hepatocyte growth factor in rat plantaris muscle following denervation and compensatory overload

Yamaguchi

Ishii

Morita

et al. 2004

Pflugers Arch - Eur J Physiol

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We addressed the question of whether hypertrophy induced by compensatory overload differs according to innervation status, and how fibroblast growth factors (FGF) and hepatocyte growth factor (HGF) mRNAs are expressed in the rat plantaris muscle during overload (OL) and/or denervation. Male Wistar rats were divided into four groups (Normal-Cont, Normal-OL, Denervated-Cont, and Denervated-OL). according to the plantaris denervation and/or overload. Three weeks later, plantaris weight in Denervated-Cont and Denervated-OL was significantly lower than in the Normal-Cont. The muscle weights in the Normal-OL were higher than in the Normal-Cont. The muscle weights in the Denervated-OL were higher than in the Denervated-Cont. Three days after the treatment, FGF-2, FGF-6, FGF-7 and HGF mRNAs in the Normal-OL were significantly higher than those in the Normal-Cont. FGF-2, FGF-6, FGF-7 and HGF mRNAs in the Denervated-OL were also significantly higher after 3 days than those in the Denervated-Cont. After 7 days, FGF-2, FGF-5, FGF-6, FGF-7 and HGF mRNAs were significantly higher in the Normal-OL than those in the Normal-Cont. At 21 days, FGF-1, FGF-6 and HGF mRNA levels were significantly increased. In the Denervated-OL, FGF-2, FGF-7 and HGF mRNAs at 7 days, and FGF-2 mRNA at 21 days were significantly higher than those in the Denervated-Cont. FGF-2 and FGF-6 mRNA levels decreased significantly following denervation; however, FGF-1, FGF-5, FGF-7 and HGF mRNA levels increased and maintained this increase for the 21-days treatment period. Muscle hypertrophy was thus induced by compensatory overload irrespective of innervation status, possibly in association with certain FGFs and HGF. The differential mRNA expression patterns of FGFs and HGF observed following compensatory overload and/or denervation suggest distinct roles for individual FGFs and HGF in muscle hypertrophy and/or atrophy.

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Section: Discussionmentioning

confidence: 99%

mRNA expression of fibroblast growth factors and hepatocyte growth factor in rat plantaris muscle following denervation and compensatory overload

Yamaguchi

Ishii

Morita

et al. 2004

Pflugers Arch - Eur J Physiol

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“…Compensatory enlargement of the plantaris muscle was induced in one leg of each mouse by surgical removal of the ipsilateral gastrocnemius and soleus muscles as described previously (Sakuma et al 1998). A sham operation was performed on the contralateral leg after the mice were anesthetized with an intraperitoneal injection of sodium pentobarbital.…”

Section: Mechanical Overloadingmentioning

confidence: 99%

Expression profile of Notch-1 in mechanically overloaded plantaris muscle of mice

et al. 2010

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“…Thus, LIF mRNA is expressed at low levels in adult muscle, but is upregulated by inflammation, 4 crush injury 7,19 or mechanical overloading. 20,21 Impaired muscle regeneration after crush injury in LIF-null mice is prevented by administration of LIF. 2 In addition, LIF has a direct proliferative effect on isolated satellite cells from rats 11 and C2C12 myoblasts.…”

Section: Discussionmentioning

confidence: 99%

Leukaemia inhibitory factor is expressed in rat gastrocnemius muscle after contusion and increases proliferation of rat L6 myoblasts via c-Myc signalling

Srikuea

Esser

Pholpramool

2011

Clinical and Experimental Pharmacology and Physiology

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SUMMARY Leukaemia inhibitory factor (LIF) has been shown to have an important role during muscle regeneration. The regenerative capacity of muscles after contusion injury in LIF-knockout mice is impaired compared with that of wild-type mice.To clarify whether LIF modulates muscle regeneration by regulating myogenic precursor cell activity, we studied LIF expression and myogenic precursor cell activity in gastrocnemius muscles from Wistar rats at various times after contusion injury using immunohistochemistry and the direct effect of LIF on a rat myoblast cell line (L6).After contusion injury, transient upregulation of the mRNA expression of LIF, LIF receptors and signal transducer and activator of transcription (STAT) 3, downstream of LIF and involved in enhanced cell proliferation, was observed. A marked increase in LIF protein in the cytosol of damaged myofibres was strongly correlated with a significant increase in the number of myogenic precursor cells (MyoD-positive cells) by 12 h after contusion. In addition, coexpression of LIF and MyoD protein in control and injured muscles after contusion injury from 3 h to 7 days was evident.Treatment of L6 cells with LIF (1 ng/mL) in serum-free medium enhanced proliferation (bromodeoxyuridine incorporation) by 24 h. This was accompanied by increased expression of c-Myc protein within 12 h and was abolished by short interference RNA against c-Myc mRNA.Together, the results of the present study suggest that LIF acts via paracrine and autocrine actions to regulate myogenic precursor cell activity during muscle regeneration after contusion injury and that the proliferative effect of LIF on L6 cells occurs via c-Myc signalling.

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Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: an immunohistochemical study

Cited by 31 publications

References 29 publications

mRNA expression of fibroblast growth factors and hepatocyte growth factor in rat plantaris muscle following denervation and compensatory overload

mRNA expression of fibroblast growth factors and hepatocyte growth factor in rat plantaris muscle following denervation and compensatory overload

Expression profile of Notch-1 in mechanically overloaded plantaris muscle of mice

Leukaemia inhibitory factor is expressed in rat gastrocnemius muscle after contusion and increases proliferation of rat L6 myoblasts via c-Myc signalling

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