Expression of Fibroblast Growth Factor 5 (FGF5) and Its Influence on Survival of Breast Cancer Patients

Huang, Yuan‐Li; Wang, Hongtao; Yang, Yuanrong

doi:10.12659/msm.907798

Cited by 19 publications

(14 citation statements)

References 32 publications

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“…It is suggested that FGF5 may be a promising treatment strategy for NSCLC. Furthermore, overexpression of FGF5 has also been revealed to contribute to malignant development in several other human tumors, such as osteosarcoma, melanoma and breast cancer ( 23 – 25 ). Similarly, in the present study, FGF5 played a role in the promotion of the malignant development of NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0016760 exacerbates the malignant development of non‑small cell lung cancer by sponging miR‑145‑5p/FGF5

Zhu

Zhang

et al. 2020

Oncol Rep

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Hsa_circ_0016760 expression has been reported to be increased in non-small cell lung cancer (NSCLC). The present study was designed to explore the role and mechanism of hsa_circ_0016760 in regulating NSCLC progression. In total, 60NSCLC patients were followed-up for 60 months after surgery. Hsa_circ_0016760 expression in tumor tissues and adjacent non-tumor tissues of NSCLC patients was explored by reverse transcription quantitative polymerase chain reaction (RT-qPCR). NSCLC cell proliferation was monitored by CCK-8 assay and EdU experiment. Transwell assays were used for the detection of NSCLC cell migration and invasion. The target of hsa_circ_0016760 (or miR-145-5p) was validated by luciferase reporter gene assay and RNA immunoprecipitation experiment. A xenograft model was studied with nude mice. Immunohistochemical staining was applied for the detection of Ki67 expression in xenograft tumors. Hsa_circ_0016760/miR-145-5p/FGF5 expression in tissues and cells was investigated by RT-qPCR and western blotting. Hsa_circ_0016760 was aberrantly upregulated in NSCLC, which was associated with poor prognosis of patients (P<0.05). Hsa_circ_0016760 silencing suppressed NSCLC cell proliferation, migration and invasion in vitro (P<0.01). Hsa_circ_0016760 facilitated FGF5 expression via sponging miR-145-5p. The miR-145-5p upregulation or FGF5 downregulation reversed the promoting effect of hsa_circ_0016760 on NSCLC cell proliferation, migration and invasion in vitro (P<0.01). In addition, hsa_circ_0016760 silencing inhibited tumor growth in vivo (P<0.01), and decreased Ki67 expression in xenograft tumors. In conclusion, hsa_circ_0016760 exacerbated the malignant development of NSCLC by sponging miR-145-5p/FGF5.

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Section: Discussionmentioning

confidence: 99%

Hsa_circ_0016760 exacerbates the malignant development of non‑small cell lung cancer by sponging miR‑145‑5p/FGF5

Zhu

Zhang

et al. 2020

Oncol Rep

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“…Zhou et al have demonstrated that the downregulation of FGF5 inhibited cell growth and invasion of human non-small-cell lung cancer cells 9 . FGF5 expression was found to be significantly upregulated in breast cancer patients relative to that in normal controls ( P < 0.0001), and breast cancer patients in the FGF5 low-expression group were correlated with better clinical characteristics 10 . Despite these findings in and the proposed tumor-promoting role of FGF5 in other malignancies, FGF5 has not been further investigated in PTC so far.…”

Section: Introductionmentioning

confidence: 92%

Validation of MicroRNA-188-5p Inhibition Power on Tumor Cell Proliferation in Papillary Thyroid Carcinoma

Zhou

Irving

et al. 2020

Cell Transplant

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Given the crucial role of microRNAs in the cellular proliferation of various types of cancers, we aimed to analyze the expression and function of a cellular proliferation-associated miR-188-5p in papillary thyroid carcinoma (PTC). Here we demonstrate that miR-188-5p is downregulated in PTC tumor tissues compared with the associated noncancerous tissues. We also validate that the miR-188-5p overexpression suppressed the PTC cancer cell proliferation. In addition, fibroblast growth factor 5 (FGF5) is observed to be downregulated in the PTC tumor tissues compared with the associated noncancerous tissues. Subsequently, FGF5 is identified as the direct functional target of miR-188-5p. Moreover, the silencing of FGF5 was found to inhibit PTC cell proliferation, which is the same pattern as miR-188-5p overexpression. These results suggest that miR-188-5p-associated silencing of FGF5 inhibits tumor cell proliferation in PTC. It also highlights the importance of further evaluating miR-188-5p as a potential biomarker and therapy target in PTC.

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“…FGF5 is overexpressed in breast cancer tissue. 608 Guo et al 609 reported that FGF6 was significantly decreased in non-metastatic liver cancer lesion tissues and increased in metastatic liver carcinoma tissue. FGF7 is expressed in normal mucosal gland epithelium and in stromal fibroblasts, and FGF7 protein levels were elevated in gastric inflammation and gastric adenocarcinoma.…”

Section: Fgf Signaling In Tumorsmentioning

confidence: 99%

FGF/FGFR signaling in health and disease

Xie

Yang

et al. 2020

Sig Transduct Target Ther

449

391

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Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

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Expression of Fibroblast Growth Factor 5 (FGF5) and Its Influence on Survival of Breast Cancer Patients

Cited by 19 publications

References 32 publications

Hsa_circ_0016760 exacerbates the malignant development of non‑small cell lung cancer by sponging miR‑145‑5p/FGF5

Hsa_circ_0016760 exacerbates the malignant development of non‑small cell lung cancer by sponging miR‑145‑5p/FGF5

Validation of MicroRNA-188-5p Inhibition Power on Tumor Cell Proliferation in Papillary Thyroid Carcinoma

FGF/FGFR signaling in health and disease

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