FGF/FGFR signaling in health and disease

Abstract

Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

EPS364, a Novel Deep-Sea Bacterial Exopolysaccharide, Inhibits Liver Cancer Cell Growth and Adhesion

“…In the presence of coreceptor KLB, the extracellular domain of FGFR4 binds with another extracellular molecule, FGF19 (fibroblast growth factor 19). FGF19 and its receptor FGFR4 are oncogenic drivers of liver cancer and associated with a poor prognosis [ 35 ]. CTNNB1 is generally considered as an intermediate regulator molecule of the FGF19-FGFR4 signaling pathway [ 28 , 36 , 37 , 38 ].…”

“…In addition, a lot of studies have shown that the downregulation of CTNNB1 was associated with the downregulations of CDH2, ALCAM and ICAM1, which is consistent with our results [ 31 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. The extracellular FGF19-FGFR4 signaling pathway mediates the expression of cell adhesion molecules and regulates specific tumorigenic events, including cancer cell proliferation and metastasis, by activating the expression of downstream intracellular genes [ 35 , 49 , 50 ]. Downregulation of the FGF19-FGFR4 signaling axis induces the generation of ROS and cell apoptosis [ 51 ].…”

Spatiotemporal sensitivity of embryonic heart specification to FGFR signaling inDrosophila

“…FGFR signalling plays a crucial role in the development and maintenance of several different organ systems in humans (heart, lungs, brain, skeletal muscles, etc.) and is also a target in disease therapies (Xie et al ., 2020). There is evidence from animal studies that FGFR signal activation has potential for use in tissue regeneration and repair (Engel et al ., 2006; Korf-Klingebiel et al ., 2011; House et al ., 2015).…”

Antiangiogenic therapy in diabetic nephropathy: A double‑edged sword (Review)

“…Therefore, FGF/FGFR signaling in DN is more likely to induce fibrosis. Their role in angiogenesis is not direct, but instead mediated via regulation of members of the RTK family, such as Eph receptors and PDGFRs ( 73 ).…”