Expression of Estrogen Receptor of the Facet Joints in Degenerative Spondylolisthesis

Ha, Kee-Yong; Chang, Cheong-Ho; Kim, Ki-Won; Kim, Younsoo; Na, Kie-Ho; Lee, Jung Hoon

doi:10.1097/01.brs.0000154674.16708.af

Cited by 67 publications

(24 citation statements)

References 30 publications

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“…According to Panjabi, FJD exacerbated as it became closer to the bottom of the lumbar, and L45 was worse than L5S1 [31, 32]. In this study, both the FFs and OWs showed that as FJD became closer to the bottom of the lumbar, its prevalence increased.…”

Section: Discussionsupporting

confidence: 49%

Comparison of facet joint degeneration in firefighters and hospital office workers

Kim¹,

An²,

Kim³

et al. 2017

Ann of Occup and Environ Med

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BackgroundThere are few published studies on the relationship between occupational lumbar load and facet joint degeneration (FJD). This cross-sectional study was conducted to evaluate the effect of physical lumbar load on FJD by comparing magnetic resonance imaging (MRI) findings of firefighters (FFs) and hospital office workers (HOWs).MethodsWe randomly sampled 341 male FFs and 80 male HOWs by age stratification. A questionnaire and clinical examination, including MRI of the lumbar spine (T12-S1), were conducted. FJD was diagnosed and graded by using the classification of Pathria et al., and reclassified into two groups as follows: no FJD (grade 0) and FJD (grades 1, 2, and 3). The prevalence of FJD was analyzed according to occupational group.ResultsThe prevalence of FJD ranged from 31% (L1–L2) to 75% (L4–L5) in the FFs, and from 18% (L1–L2) to 69% (L4–L5) in the HOWs. After adjustment for age, body mass index, and frequency of physical exercise, the adjusted odds ratios (OR) for FJD in the FFs were significantly higher than those in the HOWs at all lumbar spinal levels, except for L3–L4 (L1–L2: OR, 2.644; 95% confidence interval [CI], 1.317–5.310; L2–L3: OR, 2.285; 95% CI, 1.304–4.006; L4–L5: OR, 1.918; 95% CI, 1.037–3.544; L5–S1: OR, 1.811; 95% CI, 1.031–3.181).ConclusionThis study shows that FFs exhibit a greater likelihood of having FJD than HOWs after controlling for other risk factors of FJD. This suggests that the physical occupational demands of FFs affect their risk of developing FJD.

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Section: Discussionsupporting

confidence: 49%

Comparison of facet joint degeneration in firefighters and hospital office workers

Kim¹,

An²,

Kim³

et al. 2017

Ann of Occup and Environ Med

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“…In a study of Japanese women [12], those who were oophorectomized had an increased prevalence of anterolisthesis at L4-L5. In Ha's et al [7] study, a significant increase in the estrogen receptor in facet articular cartilage was observed in patients with degenerative spondylolisthesis. Another suggested hypothesis relates to postural differences between sexes, including differences in lumbar lordosis [17], in sacral inclination, pelvic incidence, etc.…”

Section: Discussionmentioning

confidence: 94%

Association between age, sex, BMI and CT-evaluated spinal degeneration features

Kalichman

Guermazi

et al. 2009

BMR

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“…Decreased ovarian production of hormones, particularly estrogen, is the major biological change during the female menopause 6 . In addition, estrogen receptor expression observed in LFJ cartilage has been found to correlate with the severity of LFJ arthritis 7 . Taken together, the collected evidence indicates that estrogen might play a pivotal role in regulating the metabolic homeostasis of LFJ.…”

Section: Introductionmentioning

confidence: 99%

Estrogen deficiency accelerates lumbar facet joints arthritis

Chen

Zhu

Zhang

et al. 2017

Sci Rep

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Dramatic increase in the prevalence of lumbar facet joint (LFJ) arthritis in women around the age of menopause indicates a protective role for estrogen in LFJ arthritis. To date, there is no evidence for this indication and the mechanism of such an effect remains poorly understood. In this study, ovariectomized (OVX) mice were used to mimic the estrogen-deficient status of post-menopausal women. Micro-CT and immunohistochemistry was employed to assess the morphological and molecular changes in ovariectomy-induced LFJ arthritis. The results show that the LFJ subchondral bone mass was significantly decreased in OVX mice, with increased cavities on the interface of the subchondral bone. Severe cartilage degradation was observed in ovariectomy-induced LFJ arthritis. Increased blood vessels and innervations were also found in degenerated LFJ, particularly in the subchondral bone area. 17β-Estradiol treatment efficiently suppressed LFJ subchondral bone turnover, markedly inhibited cartilage degradation, and increased blood vessel and nerve ending growth in degenerated LFJ in OVX mice. Our study reveals that estrogen is a key factor in regulating LFJ metabolism. Severe LFJ degeneration occurs when estrogen is absent in vivo. Collapsed subchondral bone may be the initiation of this process, and estrogen replacement therapy can effectively prevent degeneration of LFJ under estrogen-deficient conditions.

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Expression of Estrogen Receptor of the Facet Joints in Degenerative Spondylolisthesis

Abstract: These findings suggest that the higher expression of estrogen receptor might aggravate degenerative change of the facet articular cartilage and might also be considered one of the causative factors for DS in postmenopausal women.

Cited by 67 publications

References 30 publications

Comparison of facet joint degeneration in firefighters and hospital office workers

Comparison of facet joint degeneration in firefighters and hospital office workers

Association between age, sex, BMI and CT-evaluated spinal degeneration features

Estrogen deficiency accelerates lumbar facet joints arthritis

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