Estrogen deficiency accelerates lumbar facet joints arthritis

Chen, Hao; Zhu, Hai; Zhang, Kai; Chen, Kangwu; Yang, Huilin

doi:10.1038/s41598-017-01427-7

Cited by 25 publications

(26 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, ovariectomized mice displaying enhanced loss and collapse of cortical bone in facet joints, rapidly developed severe cartilage degeneration. Interestingly, the development of an osteoarthritic phenotype could be rescued by estrogen treatment that prevented progressive cortical bone loss [ 23 ]. While cross-sectional and longitudinal clinical imaging data of FJOA are crucially lacking, our results suggest that loss of cortical plate thickness is a prominent feature in human disease as well.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Bone Structural Parameters Reveals Subchondral Cortical Plate Resorption and Increased Trabecular Bone Remodeling in Human Facet Joint Osteoarthritis

Netzer

Distel

Wolfram

et al. 2018

IJMS

View full text Add to dashboard Cite

Facet joint osteoarthritis is a prominent feature of degenerative spine disorders, highly prevalent in ageing populations, and considered a major cause for chronic lower back pain. Since there is no targeted pharmacological therapy, clinical management of disease includes analgesic or surgical treatment. The specific cellular, molecular, and structural changes underpinning facet joint osteoarthritis remain largely elusive. The aim of this study was to determine osteoarthritis-related structural alterations in cortical and trabecular subchondral bone compartments. To this end, we conducted comparative micro computed tomography analysis in healthy (n = 15) and osteoarthritic (n = 22) lumbar facet joints. In osteoarthritic joints, subchondral cortical plate thickness and porosity were significantly reduced. The trabecular compartment displayed a 42 percent increase in bone volume fraction due to an increase in trabecular number, but not trabecular thickness. Bone structural alterations were associated with radiological osteoarthritis severity, mildly age-dependent but not gender-dependent. There was a lack of association between structural parameters of cortical and trabecular compartments in healthy and osteoarthritic specimens. The specific structural alterations suggest elevated subchondral bone resorption and turnover as a potential treatment target in facet joint osteoarthritis.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Bone Structural Parameters Reveals Subchondral Cortical Plate Resorption and Increased Trabecular Bone Remodeling in Human Facet Joint Osteoarthritis

Netzer

Distel

Wolfram

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…Multiple risk factors have been proposed for FJD, such as age, overweight, and smoking [ 1 , 5 ]. In recent studies, researchers found FJD in ovariectomy (OVX) mice [ 6 , 7 ], which indicated that estrogen deficiency may also be a risk factor for FJD. Cartilage is sensitive to sex hormones [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Salmon Calcitonin Attenuates Degenerative Changes in Cartilage and Subchondral Bone in Lumbar Facet Joint in an Experimental Rat Model

et al. 2018

View full text Add to dashboard Cite

BackgroundFacet joint degeneration (FJD) is one of the common causes of low back pain (LBP), and estrogen deficiency is one of the triggers for FJD. Calcitonin may possess the potential for treating osteoarthritis, but to date the hormone has not been studied in the treatment of FJD. Therefore, the aim of this study was to investigate the effects of salmon calcitonin (sCT) on FJD induced by estrogen deficiency after ovariectomy (OVX).Material/MethodsThirty female Sprague-Dawley rats were randomly assigned to 3 groups: the OVX group received bilateral OVX, the OVX + sCT group received subcutaneous administration of sCT (16 IU/kg/2 days) following bilateral OVX, and the Sham group received sham surgery. All rats were euthanized at 12 weeks post-OVX. Serum COMP level, cartilage degradation, and subchondral bone micro-architecture were evaluated.ResultssCT relieved cartilage surface lesions, reduced histological score, and significantly increased cartilage thickness. The OVX + sCT group exhibited significantly increased expression of aggrecan, as well as significantly decreased levels of ADAMTS-4, MMP-13, and caspase-3. The results of micro-computed tomography analysis revealed that the OVX + sCT group exhibited higher BMD, BV/TV, and Tb.Th values but a lower Tb.Sp value than that of the OVX group. Serum COMP concentrations were significantly correlated with histological score and cartilage thickness.ConclusionssCT can inhibit the progression of FJD in OVX rats, which is attributed to its inhibitory effects on cartilage metabolism imbalance, chondrocyte apoptosis, and subchondral bone remodeling. Serum COMP has diagnostic potential for FJD.

show abstract

“…Estrogen receptors are present in several cells in the joints, including cartilage cells, subchondral bone cells, and synovial cells, and the expression of estrogen receptors increases in osteoarthritis patients [22][23][24]. Experiments using ovariectomized animal models showed that a continued state of low estrogen concentration leads to decreased intra-articular subchondral bone mass, increased interface of the subchondral cavity, and progression of severe cartilage degradation [25]. Altogether, women experience rapid joint degeneration around the ages of 50-75 years after menopause, and show higher prevalence, frequency, and severity of osteoarthritis than men [6,15].…”

Section: Discussionmentioning

confidence: 99%

Relationship of Breastfeeding Duration with Joint Pain and Knee Osteoarthritis in Middle-aged Korean Women: A Cross-sectional Study using the Korea National Health and Nutrition Examination Survey

Kim

Noh

et al. 2020

Preprint

View full text Add to dashboard Cite

Background The effect of joint health on the quality of life of middle-aged and older women is becoming more widely recognized with the aging of the world’s population. However, the association of long-term breastfeeding with joint pain and knee osteoarthritis has not been fully examined. The aim of this study was to determine the association of prior breastfeeding duration with current joint pain and knee osteoarthritis in middle-aged Korean women. Methods This cross-sectional study was conducted among 3,454 women aged ≥50 years who underwent knee radiography and answered a questionnaire on breastfeeding and joint pain for the 5th Korea National Health and Nutrition Examination Survey (2010–2011). After adjusting for confounding sociodemographic, medical history, and obstetric and gynecologic variables, logistic regression analysis was conducted to analyze the prevalence of joint pain and knee osteoarthritis according to breastfeeding and its duration. Results Among the 3,454 participants, 298 had not breastfed and 1,042, 815, and 1,299 had breastfed for 1–24, 25–48, and ≥49 months, respectively. Of all participants, 1,731 had joint pain and 739 were diagnosed with knee osteoarthritis after radiography.The odds ratio (OR) for joint pain among women who breastfed was 1.49 (95% confidence interval [CI] 1.01-2.21). As the breastfeeding duration increased, the OR of joint pain prevalence also increased (p for trend; p=0.002). For knee osteoarthritis, the OR was 2.30 in the 25–48 months group (95% CI 1.09-4.86). The OR of knee osteoarthritis in the ≥49 months group was 2.17 (95% CI 1.01-4.64). Sensitivity analysis after selecting only participants aged ≥60 years showed that the prevalence of joint pain and knee osteoarthritis was more positively correlated with extended breastfeeding duration (joint pain, p for trend; p=0.005) (knee osteoarthritis, p for trend; p=0.012).Conclusions Long-term feeding for more than 25 months was associated with an increased prevalence of arthralgia and degenerative arthritis in Korean women aged ≥50 years.

show abstract

Estrogen deficiency accelerates lumbar facet joints arthritis

Cited by 25 publications

References 38 publications

Comparative Analysis of Bone Structural Parameters Reveals Subchondral Cortical Plate Resorption and Increased Trabecular Bone Remodeling in Human Facet Joint Osteoarthritis

Comparative Analysis of Bone Structural Parameters Reveals Subchondral Cortical Plate Resorption and Increased Trabecular Bone Remodeling in Human Facet Joint Osteoarthritis

Salmon Calcitonin Attenuates Degenerative Changes in Cartilage and Subchondral Bone in Lumbar Facet Joint in an Experimental Rat Model

Relationship of Breastfeeding Duration with Joint Pain and Knee Osteoarthritis in Middle-aged Korean Women: A Cross-sectional Study using the Korea National Health and Nutrition Examination Survey

Contact Info

Product

Resources

About