Expression of E-cadherin, Twist, and p53 and their prognostic value in patients with oral squamous cell carcinoma

Abstract

E-cadherin is an independent marker for survival prediction in OSCC. Co-evaluation of E-cadherin and p53 expression might be a valuable tool for predicting OSCC patient outcome.

p63 and E-cadherin Expression in Canine Oral Squamous Cell Carcinoma

“…40 E-cadherin is a hallmark in this process, being involved in the epithelial-to-mesenchymal transition mechanism also in SCC, whereas a downregulation of this cell adhesion molecule is associated with a poor prognosis in terms of recurrence and mortality. 12,18,40 Contrarily, recent reports showed that p63 expression reintroduces epithelial characteristics in mesenchymal type cells and therefore reverses the mesenchymal tendency of epithelial tumors. 18,31 These 2 markers seem to act as regulatory molecules in the epithelial-to-mesenchymal transition equilibrium.…”

“…Taken together, these results suggest that a change in the expression of these 2 molecules could be a common event in oral SCC in dogs, similar to what occurs in humans. 7,12 Epithelial-to-mesenchymal transition is an essential process in tumor progression, being implicated in gain of invasiveness and capacity to escape from the primary site and metastasize. 40 E-cadherin is a hallmark in this process, being involved in the epithelial-to-mesenchymal transition mechanism also in SCC, whereas a downregulation of this cell adhesion molecule is associated with a poor prognosis in terms of recurrence and mortality.…”

“…4,12 However, there is a lack of understanding of the molecular pathogenesis underlying this cancer. 37 Substantial data indicate that both proteins play a relevant role in SCC initiation and progression.…”

“…12,22 In dogs, this marker has mostly been studied in mammary tumors, specifically with the reduction of its expression associated with tumor size, histologic type, invasion, lymph node metastasis, grade, and mitotic index. 5,14,25 Proliferating cell nuclear antigen (PCNA) is a 36-kDa nonhistonic nuclear peptide necessary in DNA replication and cell proliferation, and it has been used as a proliferation marker by different researchers in various canine tumors 15,21,24 and in oral SCC in humans.…”

Expression profiles of selected genes in tumors and matched surgical margins in oral cavity cancer: Do we have to pay attention to the molecular analysis of the surgical margins?

“…41 It has been reported that the loss of protein expression of CDH1 is also associated with an increased invasive potential in head and neck cancer. 42 In a study conducted on clinical samples collected from patients with tongue squamous cell carcinoma, a significantly lower CDH1 mRNA expression level than in the corresponding noncancerous tissues was shown. 31 In our study, no significant differences were found between the CDH1 gene expression levels of the tumors and the surgical margin samples.…”