Expression profiles of selected genes in tumors and matched surgical margins in oral cavity cancer: Do we have to pay attention to the molecular analysis of the surgical margins?

Abstract

Background. Head and neck squamous cell carcinomas (HNSCCs) are associated with an interplay between genetics and the environment; they account for 3% of all diagnosed malignant tumors in men and 2% of those in women.

The management of oral cancer – current standards and future perspectives. Review of the literature

“…In recent years, there have also been tested a number of studies investigating the role of various genetic and molecular factors in postoperative material and surgical margins -including PTEN [56], TIMP3, SFRP1, SFRP2, CDH1, RASSF1, RORA, DAPK1 [57], TIL -tumour-infiltrating lymphocytes [58] and many others [59][60][61]. However, a clear statement of their clinical utility requires further research.…”

HOXA1 3′UTR Methylation Is a Potential Prognostic Biomarker in Oral Squamous cell Carcinoma

“…Several studies have investigated the potential of epigenetic changes in normal adjacent margins of the tumor as prognostic factors for OSCC patients [ 24 , 25 , 26 , 27 ]. Most of them showed that NAT samples, even if histologically negative for cancer cells, already have changes that can affect diagnosis and prognosis [ 27 , 28 , 29 , 30 ].…”