Expression of e-cadherin and β-catenin in human esophageal squamous cell carcinoma: relationships with prognosis

Zhao, Xixi

doi:10.3748/wjg.v9.i2.225

Cited by 53 publications

(49 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cadherins, belong to a family of transmembrane glycoproteins, are adhesion molecules responsible for homophilic interaction of calcium-dependent cell-cell adhesion (Zhao et al, 2003). Among them, E-cadherin is a classical cadherin that forms the functional component of adherens junctions between epithelial cells (Hirohashi et al, 1998), and β-catenin, is a multifunctional protein which links E-cadherin and α-catenin to cytoskeleton to constitute E-cadherin-catenin complex (Ilyas et al, 1997;Wijnhoven et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis

Zeng

Duan²,

Kong³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Many studies have reported β-catenin involvement in the development of esophageal carcinoma (EC), but its prognostic significance for EC patients remains controversial. Therefore, we conducted this meta-analysis to explore the issue in detail. After searching PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature Database, we included a total of ten relevant studies. We pooled the overall survival (OS) data using RevMan 5.2 software. The results showed that aberrant expression of β-catenin was associated with a significant increase of mortality risk (hazard ratio 1.71, 95%CI 1.46-2.01; p<0.00001). Subgroup analyses further suggested that aberrant expression of β-catenin resulted in poor OS of EC patients regardless of histological type of EC, study location or criteria for aberrant expression of β-catenin, and the sensitivity analyses revealed that the result was robust. The meta-analysis revealed that aberrant expression of β-catenin could be a predicative factor of poor prognosis for EC patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis

Zeng

Duan²,

Kong³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…While the immunohistochemical expression of ·-, ß-and Á-catenin in ESCC has been examined, the results reported regarding their clinicopathological significance for patient prognosis have been inconsistent (5,6,(9)(10)(11)(12)(13). The present study used surgically dissected samples of ESCC to investigate the immunohistochemical expression of ·-, ß-and Á-catenin in order to determine their combined effect on the prognosis of patients with ESCC.…”

Section: Introductionmentioning

confidence: 99%

“…Among the various adhesion molecules, the expression of E-cadherin has primarily been investigated, and a significant correlation between its expression and a favorable prognosis in cancer patients, including those with ESCC, has been reported (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Reduced expression of catenin subtypes is a potential indicator of unfavorable prognosis in esophageal squamous cell carcinoma

et al. 2009

View full text Add to dashboard Cite

Abstract. Catenins are cytoplasmic proteins that play a pivotal role in cell adhesion. Conflicting results regarding the significance of their expression in esophageal squamous cell carcinoma (ESCC) have been reported. The expression of ·-, ß-and Á-catenin was examined using immunohistochemical methods in 69 samples collected from patients with ESCC who were surgically treated without any preoperative induction therapy. Reduced ·-, ß-and Á-catenin expression was observed in 48 (69.7%), 36 (52.2%) and 44 (63.8%) ESCC samples, respectively. According to univariate analysis, ESCC patients exhibiting the reduced expression of ß-catenin (P=0.028), Á-catenin (P=0.010), ·-and Á-catenin combined (P=0.047) or ß-and Á-catenin combined (P=0.046) had a significantly more unfavorable rate of survival. Multivariate analysis demonstrated that the reduced expression of Á-catenin (P=0.015) as well as lymph node metastasis (P=0.015) could serve as independent prognostic indicators of unfavorable prognosis in ESCC patients. Reduced immunohistochemical expression of Á-catenin may thus prove to be a powerfull and useful predictor of prognosis in patients with ESCC. IntroductionThe migration of cancer cells from the cancer nest is an initial event in the formation of tumor metastasis (1). Previous investigations have demonstrated that the expression of adhesion molecules, which prevent cancer cells from detaching, is a potential indicator of favorable prognosis in patients and/or of less invasive behavior in gastrointestinal cancer types, including esophageal squamous cell carcinoma (ESCC) (2-4).Among the various adhesion molecules, the expression of E-cadherin has primarily been investigated, and a significant correlation between its expression and a favorable prognosis in cancer patients, including those with ESCC, has been reported (5-7).Catenins (·-, ß-and Á-) are cytoplasmic proteins that bind to the conserved tail of the epithelial E-cadherin molecule and play a crucial role in E-cadherin-mediated intracellular signal transduction and cell adhesion. The cytoplasmic domain of E-cadherin binds to ß-or Á-catenin, while ·-catenin binds to the E-cadherin -ß-and -Á-catenin complexes to maintain the cellular cytoskeleton (8).While the immunohistochemical expression of ·-, ß-and Á-catenin in ESCC has been examined, the results reported regarding their clinicopathological significance for patient prognosis have been inconsistent (5,6,9-13). The present study used surgically dissected samples of ESCC to investigate the immunohistochemical expression of ·-, ß-and Á-catenin in order to determine their combined effect on the prognosis of patients with ESCC. Patients and methodsPatients and samples. Sixty-nine consecutive specimens of ESCC from patients surgically treated in our department between 1992 and 2003 were obtained. The study population consisted of 63 men and 6 women with a median age of 64 years (range 42-83). Preoperative induction therapy was not performed in any of the cases. Continuous follow-up of the patients was carried ou...

show abstract

“…E-cadherin exerts its tumor suppressor function by playing a critical role in the development and maintenance of intercellular adhesion cell polarity and tissue architecture [16]. Previous studies on ESCC showed that E-cadherin expression is reduced in 57-66% primary tumors and reduced expression is associated with lymphatic metastasis and poor overall survival [10,11,17,18]. There are no conclusive results regarding Ecadherin expression level in metastatic sites compared with the primary tumors.…”

Section: Discussionmentioning

confidence: 61%

CyclinD1, p53, E‐cadherin, and VEGF discordant expression in paired regional metastatic lymph nodes of esophageal squamous cell carcinoma: A tissue array analysis

Luo

Wen

et al. 2011

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

Expression of e-cadherin and β-catenin in human esophageal squamous cell carcinoma: relationships with prognosis

Abstract: As a probable independent prognostic factor, it correlates with overall and disease free survival period, expression of E-cadherin but not beta-catenin may predict prognosis in patients with ESCC.

Cited by 53 publications

References 61 publications

Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis

Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis

Reduced expression of catenin subtypes is a potential indicator of unfavorable prognosis in esophageal squamous cell carcinoma

CyclinD1, p53, E‐cadherin, and VEGF discordant expression in paired regional metastatic lymph nodes of esophageal squamous cell carcinoma: A tissue array analysis

Contact Info

Product

Resources

About